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Ugp2 UDP-glucose pyrophosphorylase 2 [ Mus musculus (house mouse) ]

Gene ID: 216558, updated on 11-Apr-2024

Summary

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Official Symbol
Ugp2provided by MGI
Official Full Name
UDP-glucose pyrophosphorylase 2provided by MGI
Primary source
MGI:MGI:2183447
See related
Ensembl:ENSMUSG00000001891 AllianceGenome:MGI:2183447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UDPGP; UGPase
Summary
Predicted to enable several functions, including UTP:glucose-1-phosphate uridylyltransferase activity; glucose binding activity; and pyrimidine ribonucleotide binding activity. Predicted to be involved in several processes, including UDP-glucose metabolic process; glucose 1-phosphate metabolic process; and glycogen biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 25.7), bladder adult (RPKM 25.1) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A3.1; 11 13.89 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (21271126..21321267, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (21321126..21371267, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28840 Neighboring gene VPS54 GARP complex subunit Neighboring gene predicted gene, 23582 Neighboring gene tudor and KH domain containing protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_28841 Neighboring gene microRNA 1933 Neighboring gene STARR-positive B cell enhancer ABC_E5209 Neighboring gene STARR-seq mESC enhancer starr_28843 Neighboring gene STARR-seq mESC enhancer starr_28844 Neighboring gene STARR-positive B cell enhancer ABC_E5210 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene Neighboring gene STARR-seq mESC enhancer starr_28847 Neighboring gene RAB5C, member RAS oncogene family pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth. Wolfe AL, et al. Proc Natl Acad Sci U S A, 2021 Aug 3. PMID 34330832, Free PMC Article
  2. Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Ma J, et al. Nat Commun, 2020 Apr 14. PMID 32286295, Free PMC Article
  3. Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases. Perenthaler E, et al. Acta Neuropathol, 2020 Mar. PMID 31820119, Free PMC Article
  4. Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. Pescador N, et al. PLoS One, 2010 Mar 12. PMID 20300197, Free PMC Article
  5. Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction. Eaton M, et al. PLoS One, 2020. PMID 31917811, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38262

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UTP-monosaccharide-1-phosphate uridylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables UTP:glucose-1-phosphate uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UTP:glucose-1-phosphate uridylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables UTP:glucose-1-phosphate uridylyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables glucose binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrimidine ribonucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose 1-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in glycogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UTP--glucose-1-phosphate uridylyltransferase
Names
uridindiphosphoglucosepyrophosphorylase 2
NP_001277563.1
NP_647458.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290634.1 → NP_001277563.1  UTP--glucose-1-phosphate uridylyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001277563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK033445, AL833772, BQ033764, BY273488, CJ098156
    Consensus CDS
    CCDS70148.1
    UniProtKB/TrEMBL
    Q3U548, Q8R0M2
    Related
    ENSMUSP00000056324.6, ENSMUST00000060895.6
    Conserved Domains (1) summary
    pfam01704
    Location:46 → 462
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

  2. NM_139297.6 → NP_647458.1  UTP--glucose-1-phosphate uridylyltransferase isoform 1

    See identical proteins and their annotated locations for NP_647458.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK033445, AL833772, BQ033764, BY729023
    Consensus CDS
    CCDS24464.1
    UniProtKB/Swiss-Prot
    Q8R3D2, Q91ZJ5
    UniProtKB/TrEMBL
    Q8R0M2
    Related
    ENSMUSP00000099939.5, ENSMUST00000102875.11
    Conserved Domains (1) summary
    pfam01704
    Location:57 → 473
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    21271126..21321267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZJ5.3 GenPept UniProtKB/Swiss-Prot:Q91ZJ5

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