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Rnpep arginyl aminopeptidase (aminopeptidase B) [ Mus musculus (house mouse) ]

Gene ID: 215615, updated on 11-Apr-2024

Summary

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Official Symbol
Rnpepprovided by MGI
Official Full Name
arginyl aminopeptidase (aminopeptidase B)provided by MGI
Primary source
MGI:MGI:2384902
See related
Ensembl:ENSMUSG00000041926 AllianceGenome:MGI:2384902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and transition metal ion binding activity. Predicted to be involved in negative regulation of blood pressure and proteolysis. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and secretory granule. Predicted to be active in extracellular space. Is expressed in central nervous system and sensory organ. Orthologous to human RNPEP (arginyl aminopeptidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 45.6), large intestine adult (RPKM 34.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 58.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135190447..135211765, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135262699..135284423, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nucleosome assembly protein 1-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02360 Neighboring gene E74-like factor 3 Neighboring gene myeloma-overexpressed gene 2 protein homolog Neighboring gene translocase of inner mitochondrial membrane 17a Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:137210226-137210413

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B. Fontés G, et al. Endocrinology, 2005 Feb. PMID 15539558
  2. A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea. Kathiresan T, et al. Mol Cell Proteomics, 2009 Aug. PMID 19423573, Free PMC Article
  3. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miniglucagon-generating endopeptidase is composed of NRDc and aminopeptidase B acting sequentially
    Title: Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29229

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cobalt ion binding ISO
Inferred from Sequence Orthology
more info
  
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloaminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aminopeptidase B
Names
AP-B
arginine aminopeptidase
cytosol aminopeptidase IV
NP_001153096.1
NP_663392.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159624.2 → NP_001153096.1  aminopeptidase B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130277
    Consensus CDS
    CCDS48373.1
    UniProtKB/TrEMBL
    E9PYF1, Q8BMH2
    Related
    ENSMUSP00000073962.8, ENSMUST00000074357.8
    Conserved Domains (2) summary
    cd09599
    Location:24 → 445
    M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
    pfam09127
    Location:491 → 606
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

  2. NM_145417.4 → NP_663392.2  aminopeptidase B isoform 1

    See identical proteins and their annotated locations for NP_663392.2

    Status: VALIDATED

    Source sequence(s)
    AC130277
    Consensus CDS
    CCDS15317.1
    UniProtKB/Swiss-Prot
    Q3TX27, Q8VCT3
    UniProtKB/TrEMBL
    Q8BMH2
    Related
    ENSMUSP00000076564.8, ENSMUST00000077340.14
    Conserved Domains (3) summary
    cd09599
    Location:24 → 484
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    TIGR02411
    Location:24 → 634
    leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
    pfam09127
    Location:504 → 644
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

RNA

  1. NR_185276.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130277

  2. NR_185277.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130277

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135190447..135211765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCT3.2 GenPept UniProtKB/Swiss-Prot:Q8VCT3

Gene LinkOut

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