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Pstk phosphoseryl-tRNA kinase [ Mus musculus (house mouse) ]

Gene ID: 214580, updated on 11-Apr-2024

Summary

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Official Symbol
Pstkprovided by MGI
Official Full Name
phosphoseryl-tRNA kinaseprovided by MGI
Primary source
MGI:MGI:2685945
See related
Ensembl:ENSMUSG00000063179 AllianceGenome:MGI:2685945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1099; 5430423O14Rik; 5730458D16Rik
Summary
Enables L-seryl-tRNA(Sec) kinase activity and tRNA binding activity. Acts upstream of or within selenocysteine incorporation. Located in mitochondrion. Orthologous to human PSTK (phosphoseryl-tRNA kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 10.3), adrenal adult (RPKM 10.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 73.94 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (130972843..130994497)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (131371113..131392768)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310057M21 gene Neighboring gene family with sequence similarity 24, member A Neighboring gene STARR-positive B cell enhancer ABC_E9713 Neighboring gene STARR-positive B cell enhancer ABC_E8214 Neighboring gene STARR-seq mESC enhancer starr_20280 Neighboring gene STARR-seq mESC enhancer starr_20281 Neighboring gene IKAROS family zinc finger 5 Neighboring gene STARR-positive B cell enhancer ABC_E4981 Neighboring gene acyl-Coenzyme A dehydrogenase, short/branched chain Neighboring gene motile sperm domain containing 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential expression profile analysis of PSTK-regulated mRNAs in podocytes. Zheng D, et al. J Cell Biochem, 2019 Jun. PMID 28419530
  2. PSTK is a novel gene associated with early lung injury in Paraquat Poisoning. Zheng D, et al. Life Sci, 2015 Feb 15. PMID 25592138
  3. Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. Carlson BA, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15317934, Free PMC Article
  4. hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function. Ye J, et al. Proc Natl Acad Sci U S A, 2015 Jun 9. PMID 26039991, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study identified a set of candidate genes that are putatively regulated by PSTK in podocytes.
    Title: Differential expression profile analysis of PSTK-regulated mRNAs in podocytes.
  2. PSTK is a novel gene associated with early lung injury in Paraquat Poisoning.
    Title: PSTK is a novel gene associated with early lung injury in Paraquat Poisoning.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables L-seryl-tRNA(Sec) kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within selenocysteine incorporation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
L-seryl-tRNA(Sec) kinase
Names
O-phosphoseryl-tRNA(Sec) kinase
NP_001034623.1
NP_001351090.1
XP_006507618.1
XP_006507620.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039534.1 → NP_001034623.1  L-seryl-tRNA(Sec) kinase isoform 1

    See identical proteins and their annotated locations for NP_001034623.1

    Status: VALIDATED

    Source sequence(s)
    AI173292, AK077585, AU255311, AV333054
    Consensus CDS
    CCDS21914.1
    UniProtKB/Swiss-Prot
    Q0D2I7, Q14C09, Q8BP74
    Related
    ENSMUSP00000075037.7, ENSMUST00000075610.13
    Conserved Domains (2) summary
    TIGR03575
    Location:20 → 358
    selen_PSTK_euk; L-seryl-tRNA(Sec) kinase, eukaryotic
    pfam08433
    Location:20 → 343
    KTI12; Chromatin associated protein KTI12

  2. NM_001364161.1 → NP_001351090.1  L-seryl-tRNA(Sec) kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156606
    Conserved Domains (1) summary
    cl17190
    Location:20 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    130972843..130994497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507555.5 → XP_006507618.1  L-seryl-tRNA(Sec) kinase isoform X1

    See identical proteins and their annotated locations for XP_006507618.1

    Conserved Domains (1) summary
    cl17190
    Location:20 → 294
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. XM_006507557.5 → XP_006507620.1  L-seryl-tRNA(Sec) kinase isoform X2

    Related
    ENSMUSP00000118636.2, ENSMUST00000145114.8
    Conserved Domains (1) summary
    cl17190
    Location:20 → 262
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177609.2: Suppressed sequence

    Description
    NM_177609.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BP74.2 GenPept UniProtKB/Swiss-Prot:Q8BP74

Gene LinkOut

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