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Tfap2c transcription factor AP-2, gamma [ Mus musculus (house mouse) ]

Gene ID: 21420, updated on 26-Mar-2024

Summary

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Official Symbol
Tfap2cprovided by MGI
Official Full Name
transcription factor AP-2, gammaprovided by MGI
Primary source
MGI:MGI:106032
See related
Ensembl:ENSMUSG00000028640 AllianceGenome:MGI:106032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Stra2; Ap-2.2; Tcfap2c; AP2gamma
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; germ-line stem cell population maintenance; and trophectodermal cell differentiation. Located in nucleus. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo mesenchyme; genitourinary system; and nervous system. Orthologous to human TFAP2C (transcription factor AP-2 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 23.9), CNS E14 (RPKM 3.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Tfap2c in Genome Data Viewer
Location:
2 H3; 2 94.87 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172387599..172400542)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172545678..172558622)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 40009 Neighboring gene STARR-seq mESC enhancer starr_06577 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06579 Neighboring gene predicted gene, 35864 Neighboring gene STARR-seq mESC enhancer starr_06580 Neighboring gene STARR-seq mESC enhancer starr_06586 Neighboring gene predicted gene, 35982 Neighboring gene STARR-seq mESC enhancer starr_06588 Neighboring gene predicted gene, 36038 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172445573-172445774

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods. Loureiro-Campos E, et al. Elife, 2021 Dec 3. PMID 34859784, Free PMC Article
  2. AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells. Gu VW, et al. Stem Cell Reports, 2021 Jan 12. PMID 33382976, Free PMC Article
  3. TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition. Wang Y, et al. Cell Death Dis, 2020 Jun 25. PMID 32587258, Free PMC Article
  4. Placental insufficiency contributes to fatty acid metabolism alterations in aged female mouse offspring. Stojanovska V, et al. Am J Physiol Regul Integr Comp Physiol, 2018 Dec 1. PMID 30207754
  5. Reduced Gene Dosage of Tfap2c Impairs Trophoblast Lineage Differentiation and Alters Maternal Blood Spaces in the Mouse Placenta. Kaiser S, et al. Biol Reprod, 2015 Aug. PMID 26063869

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Does TFAP2C govern conflicting cell fates in mouse preimplantation embryos?
    Title: Does TFAP2C govern conflicting cell fates in mouse preimplantation embryos?
  2. TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription.
    Title: TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription.
  3. HN1L/AP-2gamma/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.
    Title: HN1L/AP-2γ/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.
  4. Constitutive deficiency of the neurogenic hippocampal modulator AP2gamma promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods.
    Title: Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods.
  5. AP-2gamma Is Required for Maintenance of Multipotent Mammary Stem Cells.
    Title: AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells.
  6. TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition.
    Title: TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition.
  7. Developmental clock and mechanism of de novo polarization of the mouse embryo.
    Title: Developmental clock and mechanism of de novo polarization of the mouse embryo.
  8. TFAP2C in trophoblasts controls proliferation by repressing Cdkn1a and activating the MAPK pathway, further supporting differentiation of glycogen cells by activating the AKT pathway
    Title: Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest.
  9. these findings indicate that a reduction in the gene dosage of placental Tfap2c leads to morphological changes in the labyrinth at midgestation
    Title: Reduced Gene Dosage of Tfap2c Impairs Trophoblast Lineage Differentiation and Alters Maternal Blood Spaces in the Mouse Placenta.
  10. TFAP2C regulates tumorigenesis, cell growth and survival in HER2-amplified breast cancer through transcriptional regulation of EGFR.
    Title: The role of Tcfap2c in tumorigenesis and cancer growth in an activated Neu model of mammary carcinogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within forebrain neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hair follicle development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within keratinocyte development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sebaceous gland development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skin development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stem cell population maintenance IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within trophectodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription factor AP-2 gamma
Names
AP2-gamma
activating enhancer-binding protein 2 gamma
stimulated by retinoic acid gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159696.1 → NP_001153168.1  transcription factor AP-2 gamma isoform 2

    See identical proteins and their annotated locations for NP_001153168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a unique start codon, compared to variant 1. The encoded protein (isoform 2) is longer than isoform 1.
    Source sequence(s)
    AK145603, BQ033542, CJ080187, X94694
    Consensus CDS
    CCDS50810.1
    UniProtKB/TrEMBL
    A2APA8, Q3ULB3
    Related
    ENSMUSP00000129922.2, ENSMUST00000170744.2
    Conserved Domains (1) summary
    pfam03299
    Location:260 → 458
    TF_AP-2; Transcription factor AP-2

  2. NM_009335.2 → NP_033361.2  transcription factor AP-2 gamma isoform 1

    See identical proteins and their annotated locations for NP_033361.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AK145603, BQ033542, BY016798, X94694
    Consensus CDS
    CCDS17135.1
    UniProtKB/Swiss-Prot
    Q61312, Q99L72
    UniProtKB/TrEMBL
    A0A023UF19, Q3URU7
    Related
    ENSMUSP00000030391.3, ENSMUST00000030391.9
    Conserved Domains (1) summary
    pfam03299
    Location:221 → 419
    TF_AP-2; Transcription factor AP-2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    172387599..172400542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499103.5 → XP_006499166.1  transcription factor AP-2 gamma isoform X2

    UniProtKB/TrEMBL
    Q3URU7
    Conserved Domains (1) summary
    pfam03299
    Location:214 → 409
    TF_AP-2; Transcription factor AP-2

  2. XM_017316957.2 → XP_017172446.1  transcription factor AP-2 gamma isoform X3

    UniProtKB/TrEMBL
    Q3URU7
    Conserved Domains (1) summary
    pfam03299
    Location:208 → 403
    TF_AP-2; Transcription factor AP-2

  3. XM_006499102.4 → XP_006499165.1  transcription factor AP-2 gamma isoform X1

    UniProtKB/TrEMBL
    Q3URU7
    Related
    ENSMUST00000128406.8
    Conserved Domains (1) summary
    pfam03299
    Location:229 → 424
    TF_AP-2; Transcription factor AP-2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61312.2 GenPept UniProtKB/Swiss-Prot:Q61312

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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