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Xist inactive X specific transcripts [ Mus musculus (house mouse) ]

Gene ID: 213742, updated on 5-Mar-2024

Summary

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Official Symbol
Xistprovided by MGI
Official Full Name
inactive X specific transcriptsprovided by MGI
Primary source
MGI:MGI:98974
See related
Ensembl:ENSMUSG00000086503 AllianceGenome:MGI:98974
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A430022B11
Summary
X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome. It is essential for the initiation and spread of X-inactivation. It silences hundreds of genes by recruiting and tethering repressive chromatin-modifying complexes to the inactive X chromosome. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
Expression
Broad expression in limb E14.5 (RPKM 75.7), CNS E11.5 (RPKM 39.9) and 19 other tissues See more
Orthologs
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Genomic context

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See Xist in Genome Data Viewer
Location:
X D; X 46.15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (102503979..102526839, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (103460373..103483233, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47688 Neighboring gene predicted gene 9516 Neighboring gene cysteine-rich hydrophobic domain 1 Neighboring gene testis specific X-linked gene Neighboring gene STARR-seq mESC enhancer starr_47691 Neighboring gene origin of replication in Tsix Neighboring gene X (inactive)-specific transcript, opposite strand Neighboring gene origin of replication in exon 1 of Xist Neighboring gene ribosomal protein S12, pseudogene 1 Neighboring gene predicted gene 14861

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IncRNA XIST Promotes Cardiac Fibrosis in Mice with Diabetic Nephropathy via Sponging miR-106a-5p to Target RUNX1. Xu J, et al. Crit Rev Eukaryot Gene Expr, 2023. PMID 36734857
  2. Xist exerts gene-specific silencing during XCI maintenance and impacts lineage-specific cell differentiation and proliferation during hematopoiesis. Yang T, et al. Nat Commun, 2022 Aug 1. PMID 35915095, Free PMC Article
  3. LncRNA XIST promotes mitochondrial dysfunction of hepatocytes to aggravate hepatic fibrogenesis via miR-539-3p/ADAMTS5 axis. Wu XJ, et al. Mol Cell Biochem, 2023 Feb. PMID 35794289
  4. Elastic dosage compensation by X-chromosome upregulation. Lentini A, et al. Nat Commun, 2022 Apr 6. PMID 35388014, Free PMC Article
  5. lncRNA XIST induces Aβ accumulation and neuroinflammation by the epigenetic repression of NEP in Alzheimer's disease. Yan XW, et al. J Neurogenet, 2022 Mar. PMID 35098860

See all (366) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long noncoding RNA XIST inhibition promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-145a-5p that targets SIRT1 in late-onset hypogonadism.
    Title: Long noncoding RNA XIST inhibition promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-145a-5p that targets SIRT1 in late-onset hypogonadism.
  2. Xist ribonucleoproteins promote female sex-biased autoimmunity.
    Title: Xist ribonucleoproteins promote female sex-biased autoimmunity.
  3. Gender dimorphism in hepatocarcinogenesis-DNA methylation modification regulated X-chromosome inactivation escape molecule XIST.
    Title: Gender dimorphism in hepatocarcinogenesis-DNA methylation modification regulated X-chromosome inactivation escape molecule XIST.
  4. GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers.
    Title: GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers.
  5. IncRNA XIST Promotes Cardiac Fibrosis in Mice with Diabetic Nephropathy via Sponging miR-106a-5p to Target RUNX1.
    Title: IncRNA XIST Promotes Cardiac Fibrosis in Mice with Diabetic Nephropathy via Sponging miR-106a-5p to Target RUNX1.
  6. LncRNA XIST promotes mitochondrial dysfunction of hepatocytes to aggravate hepatic fibrogenesis via miR-539-3p/ADAMTS5 axis.
    Title: LncRNA XIST promotes mitochondrial dysfunction of hepatocytes to aggravate hepatic fibrogenesis via miR-539-3p/ADAMTS5 axis.
  7. XIST silencing alleviated inflammation and mesangial cells proliferation in diabetic nephropathy by sponging miR-485.
    Title: XIST silencing alleviated inflammation and mesangial cells proliferation in diabetic nephropathy by sponging miR-485.
  8. Extracellular vesicle expansion of PMIS-miR-210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism.
    Title: Extracellular vesicle expansion of PMIS-miR-210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism.
  9. Adipose-derived stem cells-derived exosomes facilitate cutaneous wound healing by delivering XIST and restoring discoidin domain receptor 2.
    Title: Adipose-derived stem cells-derived exosomes facilitate cutaneous wound healing by delivering XIST and restoring discoidin domain receptor 2.
  10. Negative pressure promotes macrophage M1 polarization after Mycobacterium tuberculosis infection via the lncRNA XIST/microRNA-125b-5p/A20/NF-kappaB axis.
    Title: Negative pressure promotes macrophage M1 polarization after Mycobacterium tuberculosis infection via the lncRNA XIST/microRNA-125b-5p/A20/NF-κB axis.
Submit: New GeneRIF Correction See all GeneRIFs (140)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (26)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within inactivation of paternal X chromosome by genomic imprinting IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within inactivation of paternal X chromosome by genomic imprinting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within random inactivation of X chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within random inactivation of X chromosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within spongiotrophoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in X chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_001463.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL669964
    Related
    ENSMUST00000127786.4

  2. NR_001570.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced in the 3' end and is shorter compared to variant 1.
    Source sequence(s)
    AL669964

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    102503979..102526839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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