Format

Send to:

Choose Destination

Taf6 TATA-box binding protein associated factor 6 [ Mus musculus (house mouse) ]

Gene ID: 21343, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Taf6provided by MGI
Official Full Name
TATA-box binding protein associated factor 6provided by MGI
Primary source
MGI:MGI:109129
See related
Ensembl:ENSMUSG00000036980 AllianceGenome:MGI:109129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p80; 80kDa; Taf2e; TAFII70; TAF(II)80
Summary
Enables DNA binding activity. Predicted to be involved in several processes, including RNA polymerase II preinitiation complex assembly; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut gland; and retina. Orthologous to human TAF6 (TATA-box binding protein associated factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 50.6), ovary adult (RPKM 34.0) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Taf6 in Genome Data Viewer
Location:
5 G2; 5 76.98 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138176879..138185713, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138178617..138187451, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene microRNA 106b Neighboring gene minichromosome maintenance complex component 7 Neighboring gene microRNA 93 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138612151-138612338 Neighboring gene STARR-positive B cell enhancer ABC_E1693 Neighboring gene STARR-positive B cell enhancer ABC_E1694 Neighboring gene adaptor-related protein complex AP-4, mu 1 Neighboring gene STARR-seq mESC enhancer starr_14665 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene metallo-beta-lactamase domain containing 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Isolation of a cDNA encoding a mouse TFIID subunit containing histone H4 homology. Umehara T, et al. Gene, 1995 Aug 19. PMID 7665100
  2. Abnormal sperm in mice lacking the Taf7l gene. Cheng Y, et al. Mol Cell Biol, 2007 Apr. PMID 17242199, Free PMC Article
  3. Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening. Kurakin AV, et al. J Biol Chem, 2003 Sep 5. PMID 12829691
  4. The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. Pointud JC, et al. J Cell Sci, 2003 May 1. PMID 12665565
  5. Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice. O'Leary J, et al. PLoS One, 2011. PMID 21909369, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables aryl hydrocarbon receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex IEA
Inferred from Electronic Annotation
more info
  
part_of SLIK (SAGA-like) complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
transcription initiation factor TFIID subunit 6
Names
TAF(II)70
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80 kDa
TAFII-70
TAFII-80
TAFII80
TATA box binding protein (Tbp)-associated factor, RNA polymerase II, E
transcription initiation factor TFIID 70 kDa subunit
transcription initiation factor TFIID 80 kDa subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356600.1 → NP_001343529.1  transcription initiation factor TFIID subunit 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four transcripts encode the same protein.
    Source sequence(s)
    AC151719
    Consensus CDS
    CCDS19795.1
    UniProtKB/Swiss-Prot
    Q62311
    Conserved Domains (2) summary
    COG5095
    Location:9 → 408
    TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
    cd08050
    Location:214 → 430
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  2. NM_001356601.1 → NP_001343530.1  transcription initiation factor TFIID subunit 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four transcripts encode the same protein.
    Source sequence(s)
    AC151719
    Consensus CDS
    CCDS19795.1
    UniProtKB/Swiss-Prot
    Q62311
    Conserved Domains (2) summary
    COG5095
    Location:9 → 408
    TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
    cd08050
    Location:214 → 430
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  3. NM_001356602.1 → NP_001343531.1  transcription initiation factor TFIID subunit 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four transcripts encode the same protein.
    Source sequence(s)
    AC151719
    Consensus CDS
    CCDS19795.1
    UniProtKB/Swiss-Prot
    Q62311
    Related
    ENSMUSP00000106561.2, ENSMUST00000110936.8
    Conserved Domains (2) summary
    COG5095
    Location:9 → 408
    TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
    cd08050
    Location:214 → 430
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  4. NM_009315.4 → NP_033341.1  transcription initiation factor TFIID subunit 6

    See identical proteins and their annotated locations for NP_033341.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four transcripts encode the same protein.
    Source sequence(s)
    AC151719
    Consensus CDS
    CCDS19795.1
    UniProtKB/Swiss-Prot
    Q62311
    Related
    ENSMUSP00000048016.8, ENSMUST00000048698.14
    Conserved Domains (2) summary
    COG5095
    Location:9 → 408
    TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
    cd08050
    Location:214 → 430
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138176879..138185713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240940.2 → XP_011239242.1  transcription initiation factor TFIID subunit 6 isoform X1

    See identical proteins and their annotated locations for XP_011239242.1

    Conserved Domains (2) summary
    pfam02969
    Location:11 → 76
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:214 → 441
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  2. XM_011240936.2 → XP_011239238.1  transcription initiation factor TFIID subunit 6 isoform X1

    See identical proteins and their annotated locations for XP_011239238.1

    Conserved Domains (2) summary
    pfam02969
    Location:11 → 76
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:214 → 441
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  3. XM_030254353.2 → XP_030110213.1  transcription initiation factor TFIID subunit 6 isoform X2

    UniProtKB/Swiss-Prot
    Q62311
    Conserved Domains (2) summary
    COG5095
    Location:9 → 408
    TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
    cd08050
    Location:214 → 430
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  4. XM_011240939.3 → XP_011239241.1  transcription initiation factor TFIID subunit 6 isoform X1

    See identical proteins and their annotated locations for XP_011239241.1

    Conserved Domains (2) summary
    pfam02969
    Location:11 → 76
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:214 → 441
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  5. XM_011240938.3 → XP_011239240.1  transcription initiation factor TFIID subunit 6 isoform X1

    See identical proteins and their annotated locations for XP_011239240.1

    Conserved Domains (2) summary
    pfam02969
    Location:11 → 76
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:214 → 441
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  6. XM_036164984.1 → XP_036020877.1  transcription initiation factor TFIID subunit 6 isoform X1

    Conserved Domains (2) summary
    pfam02969
    Location:11 → 76
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:214 → 441
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  7. XM_011240937.3 → XP_011239239.1  transcription initiation factor TFIID subunit 6 isoform X1

    See identical proteins and their annotated locations for XP_011239239.1

    Conserved Domains (2) summary
    pfam02969
    Location:11 → 76
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:214 → 441
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  8. XM_030254354.2 → XP_030110214.1  transcription initiation factor TFIID subunit 6 isoform X2

    UniProtKB/Swiss-Prot
    Q62311
    Conserved Domains (2) summary
    COG5095
    Location:9 → 408
    TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
    cd08050
    Location:214 → 430
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62311.1 GenPept UniProtKB/Swiss-Prot:Q62311

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous