Tacr2 tachykinin receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tacr2provided by MGI
Official Full Name: tachykinin receptor 2provided by MGI
Primary source: MGI:MGI:98477
See related: Ensembl:ENSMUSG00000020081 AllianceGenome:MGI:98477
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Skr; Nk2r; Tac2r
Summary: Predicted to enable substance K receptor activity. Involved in regulation of uterine smooth muscle contraction. Predicted to be located in membrane; sperm flagellum; and sperm head. Predicted to be active in plasma membrane and sperm midpiece. Is expressed in adrenal gland. Human ortholog(s) of this gene implicated in asthma. Orthologous to human TACR2 (tachykinin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 85.1), colon adult (RPKM 9.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.37 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (62088217..62101769)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (62252438..62265990)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Congenital ablation of Tacr2 reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis.
Title: Congenital ablation of Tacr2 reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis.
Tacr2 negatively regulated the expression of neuronal nitric oxide synthase (nNOS) and vasoactive intestinal polypeptide (VIP). Its ablation in mice elevated the expression of nNOS and VIP, enhanced nitric oxide signaling and changed the Creb and NF-kappaB signalings, finally leading to the gastric emptying disturbance of Tacr2(-/-) mice.
Title: Ablation of Tacr2 in mice leads to gastric emptying disturbance.
NK2R-dependent neuropeptide signaling regulates Ag-specific T cell responses via activation of DC function
Title: Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.
mouse hemokinins are tachykinin NK(1) receptor-preferring uterotonic agonists in non-pregnant mice but lack action at the myometrial tachykinin NK(2) receptors present in late pregnant mice
Title: Functional characterisation of hemokinin-1 in mouse uterus.
In mouse colon, both NK1 and NK2 receptors are junctionally activated by endogenous tachykinins to cause an additive response. NK2 receptors seem to be present exclusively on smooth muscle cells.
Title: Role for NK(1) and NK(2) receptors in the motor activity in mouse colon.
Tachykinin NK2 receptor genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function.
Title: A role for tachykinins in female mouse and rat reproductive function.
NK-1R and NK-2R have important but differential roles in the regulation of cutaneous inflammatory responses
Title: Cutaneous allergic contact dermatitis responses are diminished in mice deficient in neurokinin 1 receptors and augmented by neurokinin 2 receptor blockage.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

General gene information

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Markers

UniSTS:480303 (e-PCR)
- UniSTS:480303

Tacr2 (e-PCR), detects polymorphism
- UniSTS:480303

Tacr2 (e-PCR), detects polymorphism
- UniSTS:527573

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables substance K receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables substance K receptor activity	ISO Inferred from Sequence Orthology more info
enables tachykinin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intestine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of luteinizing hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in operant conditioning	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acetylcholine secretion, neurotransmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of uterine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in prolactin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of uterine smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm head	ISO Inferred from Sequence Orthology more info
is_active_in sperm midpiece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: substance-K receptor

Names: 7 transmembrane receptor; NK-2 receptor; NK-2R; neurokinin A receptor; tachykinin NK-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.