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Itga10 integrin, alpha 10 [ Mus musculus (house mouse) ]

Gene ID: 213119, updated on 5-Mar-2024

Summary

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Official Symbol
Itga10provided by MGI
Official Full Name
integrin, alpha 10provided by MGI
Primary source
MGI:MGI:2153482
See related
Ensembl:ENSMUSG00000090210 AllianceGenome:MGI:2153482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630048L14
Summary
Predicted to enable collagen binding activity involved in cell-matrix adhesion. Predicted to be involved in cell-matrix adhesion and integrin-mediated signaling pathway. Predicted to be part of integrin alpha10-beta1 complex. Is expressed in several structures, including brain; hindlimb; sensory organ; skeleton; and testis. Orthologous to human ITGA10 (integrin subunit alpha 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 8.9), CNS E14 (RPKM 2.3) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Itga10 in Genome Data Viewer
Location:
3 F2.1; 3 41.93 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96552900..96571835)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96645584..96664519)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7929 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96439383-96439492 Neighboring gene RNA binding motif protein 8a Neighboring gene peroxisomal biogenesis factor 11 beta Neighboring gene ribosomal protein L21, pseudogene 11 Neighboring gene STARR-positive B cell enhancer ABC_E6084 Neighboring gene STARR-seq mESC enhancer starr_08444 Neighboring gene ankyrin repeat domain 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors. Engel BE, et al. Cell Death Dis, 2013 Nov 28. PMID 24287699, Free PMC Article
  2. Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants. Bengtsson T, et al. Matrix Biol, 2001 Dec. PMID 11731273
  3. BMP-2 and TGF-beta1 differentially control expression of type II procollagen and alpha 10 and alpha 11 integrins in mouse chondrocytes. Gouttenoire J, et al. Eur J Cell Biol, 2010 Apr. PMID 20129696, Free PMC Article
  4. The mesenchymal alpha11beta1 integrin attenuates PDGF-BB-stimulated chemotaxis of embryonic fibroblasts on collagens. Popova SN, et al. Dev Biol, 2004 Jun 15. PMID 15183724
  5. Positional cloning of the combined hyperlipidemia gene Hyplip1. Bodnar JS, et al. Nat Genet, 2002 Jan. PMID 11753387, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors.
    Title: Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors.
  2. The relative expressions of alpha 10 integrin subunits are good markers to define the differentiation state of chondrocytes.
    Title: BMP-2 and TGF-beta1 differentially control expression of type II procollagen and alpha 10 and alpha 11 integrins in mouse chondrocytes.
  3. integrin alpha10beta1 plays a specific role in growth plate morphogenesis and function
    Title: Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Potential readthrough

Included gene: Pex11b

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding involved in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin alpha10-beta1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
integrin alpha-10
Names
integrin subunit alpha10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302471.1 → NP_001289400.1  integrin alpha-10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112261, AC122037
    Consensus CDS
    CCDS38557.2
    UniProtKB/TrEMBL
    E9PXZ3, E9Q6R1, Q14BL5
    Related
    ENSMUSP00000112393.2, ENSMUST00000119365.8
    Conserved Domains (3) summary
    smart00191
    Location:545 → 599
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:166 → 346
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:642 → 1049
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96552900..96571835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081053.1: Suppressed sequence

    Description
    NM_001081053.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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