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EWSR1 EWS RNA binding protein 1 [ Homo sapiens (human) ]

Gene ID: 2130, updated on 12-Apr-2024

Summary

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Official Symbol
EWSR1provided by HGNC
Official Full Name
EWS RNA binding protein 1provided by HGNC
Primary source
HGNC:HGNC:3508
See related
Ensembl:ENSG00000182944 MIM:133450; AllianceGenome:HGNC:3508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EWS; EWS-FLI1; bK984G1.4
Summary
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
Expression
Ubiquitous expression in testis (RPKM 27.8), bone marrow (RPKM 27.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See EWSR1 in Genome Data Viewer
Location:
22q12.2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (29268268..29300521)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (29731759..29763936)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (29664257..29696511)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene EMI domain containing 1 Neighboring gene uncharacterized LOC105372985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29619669-29620170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29629634-29630134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29630135-29630635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29655585-29656439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29656440-29657293 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29663849-29664720 Neighboring gene rhomboid domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29698939-29699439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29701647-29702392 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29702393-29703136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29710073-29710877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29710878-29711682 Neighboring gene growth arrest specific 2 like 1 Neighboring gene RAS like family 10 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma. Showpnil IA, et al. Nucleic Acids Res, 2022 Sep 23. PMID 36124657, Free PMC Article
  2. EWSR1 rearrangement is not specific for hyalinizing clear cell carcinoma of salivary glands. Aljerian K. Ann Diagn Pathol, 2022 Aug. PMID 35500493
  3. Overexpression of EWSR1 (Ewing sarcoma breakpoint region 1/EWS RNA binding protein 1) predicts poor survival in patients with hepatocellular carcinoma. Jiang W, et al. Bioengineered, 2021 Dec. PMID 34612781, Free PMC Article
  4. EWSR1 rearrangement in papillary thyroid microcarcinoma is related to classic morphology and the presence of small-cell phenotype. Kovacevic B, et al. Bosn J Basic Med Sci, 2022 Feb 1. PMID 34374640, Free PMC Article
  5. O-Linked-N-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics. Nosella ML, et al. J Am Chem Soc, 2021 Aug 4. PMID 34304571

See all (437) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endogenous EWSR1 Exists in Two Visual Modalities That Reflect Its Associations with Nucleic Acids and Concentration at Sites of Active Transcription.
    Title: Endogenous EWSR1 Exists in Two Visual Modalities That Reflect Its Associations with Nucleic Acids and Concentration at Sites of Active Transcription.
  2. EWSR1::WT1 Fusions in Neoplasms Other Than Conventional Desmoplastic Small Round Cell Tumor: Three Tumors Occurring Outside the Female Genital Tract.
    Title: EWSR1::WT1 Fusions in Neoplasms Other Than Conventional Desmoplastic Small Round Cell Tumor: Three Tumors Occurring Outside the Female Genital Tract.
  3. Identification of Novel/Rare EWSR1 Fusion Partners in Undifferentiated Mesenchymal Neoplasms.
    Title: Identification of Novel/Rare EWSR1 Fusion Partners in Undifferentiated Mesenchymal Neoplasms.
  4. Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma.
    Title: Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma.
  5. A complex with poly(A)-binding protein and EWS facilitates the transcriptional function of oncogenic ETS transcription factors in prostate cells.
    Title: A complex with poly(A)-binding protein and EWS facilitates the transcriptional function of oncogenic ETS transcription factors in prostate cells.
  6. Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions.
    Title: Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions.
  7. Novel EWSR1::GFI1B gene fusion in angiofibroma of soft tissue.
    Title: Novel EWSR1::GFI1B gene fusion in angiofibroma of soft tissue.
  8. EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing Sarcoma.
    Title: EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing Sarcoma.
  9. TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses.
    Title: TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses.
  10. EWSR1 maintains centromere identity.
    Title: EWSR1 maintains centromere identity.
Submit: New GeneRIF Correction See all GeneRIFs (248)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Ewing sarcoma
MedGen: C0553580 OMIM: 612219 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, Ewing sarcoma breakpoint region 1 (EWSR1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with EWSR1 is increased by RRE PubMed
Vpr vpr HIV-1 Vpr upregulates EWSR1 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA-binding protein EWS
Names
Ewing sarcoma breakpoint region 1
Ewings sarcoma EWS-Fli1 (type 1) oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023240.2 RefSeqGene

    Range
    5002..37255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001163285.2 → NP_001156757.1  RNA-binding protein EWS isoform 3

    See identical proteins and their annotated locations for NP_001156757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AK225102, AW205707, BC004817, DB443651
    Consensus CDS
    CCDS54513.1
    UniProtKB/TrEMBL
    B0QYK0
    Related
    ENSP00000385726.1, ENST00000406548.5
    Conserved Domains (4) summary
    COG0724
    Location:349 → 457
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:360 → 443
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:521 → 542
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:517 → 546
    zf-RanBP; Zn-finger in Ran binding protein and others

  2. NM_001163286.2 → NP_001156758.1  RNA-binding protein EWS isoform 4

    See identical proteins and their annotated locations for NP_001156758.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK056681, AW205707, DA051447, DB443651
    Consensus CDS
    CCDS54514.1
    UniProtKB/TrEMBL
    B0QYK0
    Related
    ENSP00000331699.6, ENST00000332035.10
    Conserved Domains (4) summary
    COG0724
    Location:294 → 402
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:305 → 388
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:466 → 487
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:462 → 491
    zf-RanBP; Zn-finger in Ran binding protein and others

  3. NM_001163287.2 → NP_001156759.1  RNA-binding protein EWS isoform 5

    See identical proteins and their annotated locations for NP_001156759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, and differs in the 3' UTR and in the presence and absence of exons in the 3' coding region, compared to variant 1. The resulting isoform (5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC000527, DB443651
    Consensus CDS
    CCDS54512.1
    UniProtKB/Swiss-Prot
    Q01844
    Related
    ENSP00000327456.6, ENST00000333395.11
    Conserved Domains (1) summary
    PHA03247
    Location:71 → 206
    PHA03247; large tegument protein UL36; Provisional

  4. NM_005243.4 → NP_005234.1  RNA-binding protein EWS isoform 2

    See identical proteins and their annotated locations for NP_005234.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AW205707, BC004817, DB443651
    Consensus CDS
    CCDS13851.1
    UniProtKB/Swiss-Prot
    B0QYK1, Q01844, Q5THL0, Q92635, Q96FE8, Q96MN4, Q96MX4, Q9BWA2
    UniProtKB/TrEMBL
    B0QYK0
    Related
    ENSP00000381031.2, ENST00000397938.7
    Conserved Domains (4) summary
    COG0724
    Location:350 → 458
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:361 → 444
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:522 → 543
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:518 → 547
    zf-RanBP; Zn-finger in Ran binding protein and others

  5. NM_013986.4 → NP_053733.2  RNA-binding protein EWS isoform 1

    See identical proteins and their annotated locations for NP_053733.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK056309, AW205707, DB443651
    Consensus CDS
    CCDS13852.2
    UniProtKB/TrEMBL
    B0QYK0
    Related
    ENSP00000400142.2, ENST00000414183.6
    Conserved Domains (4) summary
    COG0724
    Location:355 → 463
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:366 → 449
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:527 → 548
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:523 → 552
    zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    29268268..29300521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529995.4 → XP_011528297.1  RNA-binding protein EWS isoform X1

    UniProtKB/TrEMBL
    B0QYK0
    Conserved Domains (4) summary
    COG0724
    Location:351 → 459
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:362 → 445
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:523 → 557
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:519 → 561
    zf-RanBP; Zn-finger in Ran binding protein and others

  2. XM_011529999.4 → XP_011528301.1  RNA-binding protein EWS isoform X7

    Conserved Domains (4) summary
    COG0724
    Location:351 → 459
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:362 → 445
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:523 → 557
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:519 → 557
    zf-RanBP; Zn-finger in Ran binding protein and others

  3. XM_011529997.3 → XP_011528299.1  RNA-binding protein EWS isoform X5

    UniProtKB/TrEMBL
    B0QYK0
    Conserved Domains (4) summary
    COG0724
    Location:351 → 459
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:362 → 445
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:523 → 544
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:519 → 548
    zf-RanBP; Zn-finger in Ran binding protein and others

  4. XM_011530000.3 → XP_011528302.1  RNA-binding protein EWS isoform X11

    Conserved Domains (4) summary
    COG0724
    Location:351 → 459
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:362 → 445
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:523 → 544
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:519 → 544
    zf-RanBP; Zn-finger in Ran binding protein and others

  5. XM_017028649.3 → XP_016884138.1  RNA-binding protein EWS isoform X15

    UniProtKB/TrEMBL
    B0QYK0
    Conserved Domains (4) summary
    smart00547
    Location:480 → 519
    ZnF_RBZ; Zinc finger domain
    PHA03247
    Location:72 → 207
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:482 → 516
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cl17169
    Location:364 → 431
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_047441190.1 → XP_047297146.1  RNA-binding protein EWS isoform X26

  7. XM_017028650.3 → XP_016884139.1  RNA-binding protein EWS isoform X18

    UniProtKB/TrEMBL
    B0QYK0

  8. XM_047441192.1 → XP_047297148.1  RNA-binding protein EWS isoform X31

  9. XM_011529996.4 → XP_011528298.1  RNA-binding protein EWS isoform X3

    UniProtKB/TrEMBL
    B0QYK0
    Conserved Domains (4) summary
    COG0724
    Location:350 → 458
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:361 → 444
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:522 → 556
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:518 → 560
    zf-RanBP; Zn-finger in Ran binding protein and others

  10. XM_017028646.3 → XP_016884135.1  RNA-binding protein EWS isoform X9

  11. XM_011529998.3 → XP_011528300.1  RNA-binding protein EWS isoform X6

    UniProtKB/TrEMBL
    B0QYK0
    Conserved Domains (4) summary
    COG0724
    Location:350 → 458
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:361 → 444
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:522 → 543
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:518 → 547
    zf-RanBP; Zn-finger in Ran binding protein and others

  12. XM_047441187.1 → XP_047297143.1  RNA-binding protein EWS isoform X13

  13. XM_017028652.3 → XP_016884141.1  RNA-binding protein EWS isoform X20

    UniProtKB/TrEMBL
    B0QYK0

  14. XM_011530002.4 → XP_011528304.1  RNA-binding protein EWS isoform X33

    UniProtKB/TrEMBL
    C9JGE3, V5JZ30
    Conserved Domains (4) summary
    COG0724
    Location:278 → 386
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:289 → 372
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:450 → 484
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:446 → 488
    zf-RanBP; Zn-finger in Ran binding protein and others

  15. XM_024452180.2 → XP_024307948.1  RNA-binding protein EWS isoform X40

    Conserved Domains (4) summary
    cd12533
    Location:289 → 372
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00030
    Location:465 → 484
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:446 → 484
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl26464
    Location:72 → 207
    Atrophin-1; Atrophin-1 family

  16. XM_047441195.1 → XP_047297151.1  RNA-binding protein EWS isoform X36

    UniProtKB/TrEMBL
    A0A0D9SFL3
    Related
    ENSP00000486709.1, ENST00000629659.2

  17. XM_047441199.1 → XP_047297155.1  RNA-binding protein EWS isoform X44

  18. XM_011530001.3 → XP_011528303.1  RNA-binding protein EWS isoform X22

    Conserved Domains (4) summary
    COG0724
    Location:295 → 403
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:306 → 389
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:467 → 501
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:463 → 505
    zf-RanBP; Zn-finger in Ran binding protein and others

  19. XM_047441191.1 → XP_047297147.1  RNA-binding protein EWS isoform X28

  20. XM_017028654.2 → XP_016884143.1  RNA-binding protein EWS isoform X24

  21. XM_017028658.2 → XP_016884147.1  RNA-binding protein EWS isoform X29

  22. XM_005261389.5 → XP_005261446.1  RNA-binding protein EWS isoform X2

    UniProtKB/TrEMBL
    B0QYK0
    Conserved Domains (4) summary
    COG0724
    Location:350 → 458
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:361 → 444
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:522 → 556
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:518 → 560
    zf-RanBP; Zn-finger in Ran binding protein and others

  23. XM_017028645.3 → XP_016884134.1  RNA-binding protein EWS isoform X8

    UniProtKB/TrEMBL
    B0QYK0

  24. XM_047441186.1 → XP_047297142.1  RNA-binding protein EWS isoform X12

  25. XM_047441188.1 → XP_047297144.1  RNA-binding protein EWS isoform X16

  26. XM_017028656.3 → XP_016884145.1  RNA-binding protein EWS isoform X27

    UniProtKB/TrEMBL
    B0QYK0

  27. XM_017028651.3 → XP_016884140.1  RNA-binding protein EWS isoform X19

    UniProtKB/TrEMBL
    B0QYK0

  28. XM_017028644.3 → XP_016884133.1  RNA-binding protein EWS isoform X4

    UniProtKB/TrEMBL
    B0QYK0

  29. XM_017028647.3 → XP_016884136.1  RNA-binding protein EWS isoform X10

    UniProtKB/TrEMBL
    B0QYK0

  30. XM_017028648.3 → XP_016884137.1  RNA-binding protein EWS isoform X14

    UniProtKB/TrEMBL
    B0QYK0

  31. XM_047441189.1 → XP_047297145.1  RNA-binding protein EWS isoform X17

  32. XM_017028653.3 → XP_016884142.1  RNA-binding protein EWS isoform X21

    UniProtKB/TrEMBL
    B0QYK0

  33. XM_017028660.3 → XP_016884149.1  RNA-binding protein EWS isoform X32

    UniProtKB/TrEMBL
    B0QYK0

  34. XM_047441193.1 → XP_047297149.1  RNA-binding protein EWS isoform X34

  35. XM_047441198.1 → XP_047297154.1  RNA-binding protein EWS isoform X41

  36. XM_047441196.1 → XP_047297152.1  RNA-binding protein EWS isoform X37

    Related
    ENSP00000330896.7, ENST00000332050.10

  37. XM_024452181.2 → XP_024307949.1  RNA-binding protein EWS isoform X42

    UniProtKB/TrEMBL
    C9JGE3, V5JZ30
    Conserved Domains (4) summary
    cd12533
    Location:288 → 371
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:449 → 470
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:445 → 470
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl26464
    Location:71 → 206
    Atrophin-1; Atrophin-1 family

  38. XM_047441200.1 → XP_047297156.1  RNA-binding protein EWS isoform X45

  39. XM_005261390.5 → XP_005261447.1  RNA-binding protein EWS isoform X23

    UniProtKB/TrEMBL
    B0QYK0
    Conserved Domains (4) summary
    COG0724
    Location:294 → 402
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:305 → 388
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:466 → 500
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:462 → 504
    zf-RanBP; Zn-finger in Ran binding protein and others

  40. XM_047441194.1 → XP_047297150.1  RNA-binding protein EWS isoform X35

  41. XM_047441197.1 → XP_047297153.1  RNA-binding protein EWS isoform X38

  42. XM_017028655.2 → XP_016884144.1  RNA-binding protein EWS isoform X25

    UniProtKB/TrEMBL
    B0QYK0

  43. XM_017028659.2 → XP_016884148.1  RNA-binding protein EWS isoform X30

    UniProtKB/TrEMBL
    B0QYK0

  44. XM_017028662.3 → XP_016884151.1  RNA-binding protein EWS isoform X39

  45. XM_017028663.2 → XP_016884152.1  RNA-binding protein EWS isoform X43

    UniProtKB/TrEMBL
    B0QYK0

  46. XM_047441201.1 → XP_047297157.1  RNA-binding protein EWS isoform X46

  47. XM_047441202.1 → XP_047297158.1  RNA-binding protein EWS isoform X47

    Related
    ENSP00000412670.2, ENST00000437155.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    29731759..29763936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325228.1 → XP_054181203.1  RNA-binding protein EWS isoform X1

  2. XM_054325234.1 → XP_054181209.1  RNA-binding protein EWS isoform X7

  3. XM_054325232.1 → XP_054181207.1  RNA-binding protein EWS isoform X5

  4. XM_054325238.1 → XP_054181213.1  RNA-binding protein EWS isoform X11

  5. XM_054325242.1 → XP_054181217.1  RNA-binding protein EWS isoform X15

  6. XM_054325253.1 → XP_054181228.1  RNA-binding protein EWS isoform X26

  7. XM_054325245.1 → XP_054181220.1  RNA-binding protein EWS isoform X18

  8. XM_054325258.1 → XP_054181233.1  RNA-binding protein EWS isoform X31

  9. XM_054325230.1 → XP_054181205.1  RNA-binding protein EWS isoform X3

  10. XM_054325236.1 → XP_054181211.1  RNA-binding protein EWS isoform X9

  11. XM_054325233.1 → XP_054181208.1  RNA-binding protein EWS isoform X6

  12. XM_054325240.1 → XP_054181215.1  RNA-binding protein EWS isoform X13

  13. XM_054325247.1 → XP_054181222.1  RNA-binding protein EWS isoform X20

  14. XM_054325260.1 → XP_054181235.1  RNA-binding protein EWS isoform X33

  15. XM_054325267.1 → XP_054181242.1  RNA-binding protein EWS isoform X40

  16. XM_054325263.1 → XP_054181238.1  RNA-binding protein EWS isoform X36

    UniProtKB/TrEMBL
    A0A0D9SFL3

  17. XM_054325271.1 → XP_054181246.1  RNA-binding protein EWS isoform X44

  18. XM_054325249.1 → XP_054181224.1  RNA-binding protein EWS isoform X22

  19. XM_054325255.1 → XP_054181230.1  RNA-binding protein EWS isoform X28

  20. XM_054325251.1 → XP_054181226.1  RNA-binding protein EWS isoform X24

  21. XM_054325256.1 → XP_054181231.1  RNA-binding protein EWS isoform X29

  22. XM_054325229.1 → XP_054181204.1  RNA-binding protein EWS isoform X2

  23. XM_054325235.1 → XP_054181210.1  RNA-binding protein EWS isoform X8

  24. XM_054325239.1 → XP_054181214.1  RNA-binding protein EWS isoform X12

  25. XM_054325243.1 → XP_054181218.1  RNA-binding protein EWS isoform X16

  26. XM_054325254.1 → XP_054181229.1  RNA-binding protein EWS isoform X27

  27. XM_054325246.1 → XP_054181221.1  RNA-binding protein EWS isoform X19

  28. XM_054325231.1 → XP_054181206.1  RNA-binding protein EWS isoform X4

  29. XM_054325237.1 → XP_054181212.1  RNA-binding protein EWS isoform X10

  30. XM_054325241.1 → XP_054181216.1  RNA-binding protein EWS isoform X14

  31. XM_054325244.1 → XP_054181219.1  RNA-binding protein EWS isoform X17

  32. XM_054325248.1 → XP_054181223.1  RNA-binding protein EWS isoform X21

  33. XM_054325259.1 → XP_054181234.1  RNA-binding protein EWS isoform X32

  34. XM_054325261.1 → XP_054181236.1  RNA-binding protein EWS isoform X34

  35. XM_054325268.1 → XP_054181243.1  RNA-binding protein EWS isoform X41

  36. XM_054325264.1 → XP_054181239.1  RNA-binding protein EWS isoform X37

  37. XM_054325269.1 → XP_054181244.1  RNA-binding protein EWS isoform X42

  38. XM_054325272.1 → XP_054181247.1  RNA-binding protein EWS isoform X45

  39. XM_054325250.1 → XP_054181225.1  RNA-binding protein EWS isoform X23

  40. XM_054325262.1 → XP_054181237.1  RNA-binding protein EWS isoform X35

  41. XM_054325265.1 → XP_054181240.1  RNA-binding protein EWS isoform X38

  42. XM_054325252.1 → XP_054181227.1  RNA-binding protein EWS isoform X25

  43. XM_054325257.1 → XP_054181232.1  RNA-binding protein EWS isoform X30

  44. XM_054325266.1 → XP_054181241.1  RNA-binding protein EWS isoform X39

  45. XM_054325270.1 → XP_054181245.1  RNA-binding protein EWS isoform X43

  46. XM_054325273.1 → XP_054181248.1  RNA-binding protein EWS isoform X46

  47. XM_054325274.1 → XP_054181249.1  RNA-binding protein EWS isoform X47

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01844.1 GenPept UniProtKB/Swiss-Prot:Q01844

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