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Satb2 special AT-rich sequence binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 212712, updated on 21-Apr-2024

Summary

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Official Symbol
Satb2provided by MGI
Official Full Name
special AT-rich sequence binding protein 2provided by MGI
Primary source
MGI:MGI:2679336
See related
Ensembl:ENSMUSG00000038331 AllianceGenome:MGI:2679336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BAP002; mKIAA1034
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within several processes, including generation of neurons; regulation of transcription by RNA polymerase II; and skeletal system development. Located in nucleus. Part of histone deacetylase complex and transcription regulator complex. Is expressed in several structures, including 1st branchial arch; cerebral cortex; facial prominence; genitourinary system; and limb. Used to study isolated cleft palate. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to human SATB2 (SATB homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 11.8), CNS E18 (RPKM 11.0) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C1.3; 1 28.72 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (56833145..57019350, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (56793981..56981190, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53554 Neighboring gene STARR-seq mESC enhancer starr_00966 Neighboring gene STARR-seq mESC enhancer starr_00967 Neighboring gene STARR-seq mESC enhancer starr_00969 Neighboring gene heat shock transcription factor, Y-linked 2 Neighboring gene STARR-seq mESC enhancer starr_00971 Neighboring gene STARR-seq mESC enhancer starr_00972 Neighboring gene STARR-seq mESC enhancer starr_00973 Neighboring gene predicted gene, 51624 Neighboring gene STARR-seq mESC enhancer starr_00974 Neighboring gene STARR-seq mESC enhancer starr_00975 Neighboring gene RIKEN cDNA 9130024F11 gene Neighboring gene predicted gene, 38484 Neighboring gene RIKEN cDNA 1700126A01 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Satb2 regulates proliferation and nuclear integrity of pre-osteoblasts. Dowrey T, et al. Bone, 2019 Oct. PMID 31325654, Free PMC Article
  2. Satb2 ablation decreases PTZ-induced seizure susceptibility and pyramidal neuronal excitability. Li Y, et al. Brain Res, 2018 Sep 15. PMID 29750936
  3. Satb2(Cre/+) mouse as a tool to investigate cell fate determination in the developing neocortex. Ambrozkiewicz MC, et al. J Neurosci Methods, 2017 Nov 1. PMID 28782628
  4. Satb2 determines miRNA expression and long-term memory in the adult central nervous system. Jaitner C, et al. Elife, 2016 Nov 29. PMID 27897969, Free PMC Article
  5. SATB2-associated syndrome presenting with Rett-like phenotypes. Lee JS, et al. Clin Genet, 2016 Jun. PMID 26596517

See all (395) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the developing cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes.
    Title: In the developing cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes.
  2. Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain.
    Title: Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain.
  3. MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex.
    Title: MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex.
  4. Satb2 Regulates EphA7 to Control Soma Spacing and Self-Avoidance of Cortical Pyramidal Neurons.
    Title: Satb2 Regulates EphA7 to Control Soma Spacing and Self-Avoidance of Cortical Pyramidal Neurons.
  5. A eutherian-specific microRNA controls the translation of Satb2 in a model of cortical differentiation.
    Title: A eutherian-specific microRNA controls the translation of Satb2 in a model of cortical differentiation.
  6. Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1.
    Title: Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1.
  7. Role of Satb1 and Satb2 Transcription Factors in the Glutamate Receptors Expression and Ca(2+) Signaling in the Cortical Neurons In Vitro.
    Title: Role of Satb1 and Satb2 Transcription Factors in the Glutamate Receptors Expression and Ca(2+) Signaling in the Cortical Neurons In Vitro.
  8. Satb2 is required for the regionalization of retrosplenial cortex.
    Title: Satb2 is required for the regionalization of retrosplenial cortex.
  9. Special AT-rich sequence-binding protein 2 (Satb2) synergizes with Bmp9 and is essential for osteo/odontogenic differentiation of mouse incisor mesenchymal stem cells.
    Title: Special AT-rich sequence-binding protein 2 (Satb2) synergizes with Bmp9 and is essential for osteo/odontogenic differentiation of mouse incisor mesenchymal stem cells.
  10. MicroRNA-31 regulates dental epithelial cell proliferation by targeting Satb2.
    Title: MicroRNA-31 regulates dental epithelial cell proliferation by targeting Satb2.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within osteoblast development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within osteoblast development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IC
Inferred by Curator
more info
 PubMed 
part_of histone deacetylase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding protein SATB2
Names
KIAA1034-like DNA binding protein
two cut domains-containing homeodomain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358580.2 → NP_001345509.1  DNA-binding protein SATB2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101777, AC131072
    Consensus CDS
    CCDS14965.1
    UniProtKB/Swiss-Prot
    Q8VI24
    UniProtKB/TrEMBL
    H3BKH3, Q546B3
    Conserved Domains (4) summary
    smart00389
    Location:614 → 671
    HOX; Homeodomain
    cd11585
    Location:60 → 155
    SATB1_N; N-terminal domain of SATB1 and similar proteins
    pfam02376
    Location:481 → 551
    CUT; CUT domain
    pfam16557
    Location:166 → 232
    CUTL; CUT1-like DNA-binding domain of SATB

  2. NM_001358581.2 → NP_001345510.1  DNA-binding protein SATB2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101777, AC131072
    Consensus CDS
    CCDS14965.1
    UniProtKB/Swiss-Prot
    Q8VI24
    UniProtKB/TrEMBL
    H3BKH3, Q546B3
    Conserved Domains (4) summary
    smart00389
    Location:614 → 671
    HOX; Homeodomain
    cd11585
    Location:60 → 155
    SATB1_N; N-terminal domain of SATB1 and similar proteins
    pfam02376
    Location:481 → 551
    CUT; CUT domain
    pfam16557
    Location:166 → 232
    CUTL; CUT1-like DNA-binding domain of SATB

  3. NM_001420844.1 → NP_001407773.1  DNA-binding protein SATB2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101777, AC131072

  4. NM_001420845.1 → NP_001407774.1  DNA-binding protein SATB2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101777, AC131072
    UniProtKB/Swiss-Prot
    Q8VI24
    UniProtKB/TrEMBL
    Q546B3

  5. NM_139146.3 → NP_631885.1  DNA-binding protein SATB2 isoform 1

    See identical proteins and their annotated locations for NP_631885.1

    Status: VALIDATED

    Source sequence(s)
    AC101777, AC131072
    Consensus CDS
    CCDS14965.1
    UniProtKB/Swiss-Prot
    Q8VI24
    UniProtKB/TrEMBL
    H3BKH3, Q546B3
    Related
    ENSMUSP00000110057.4, ENSMUST00000114415.10
    Conserved Domains (4) summary
    smart00389
    Location:614 → 671
    HOX; Homeodomain
    cd11585
    Location:60 → 155
    SATB1_N; N-terminal domain of SATB1 and similar proteins
    pfam02376
    Location:481 → 551
    CUT; CUT domain
    pfam16557
    Location:166 → 232
    CUTL; CUT1-like DNA-binding domain of SATB

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    56833145..57019350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495827.5 → XP_006495890.1  DNA-binding protein SATB2 isoform X1

    See identical proteins and their annotated locations for XP_006495890.1

    UniProtKB/TrEMBL
    H3BKH3
    Conserved Domains (4) summary
    smart00389
    Location:621 → 678
    HOX; Homeodomain
    cd11585
    Location:67 → 162
    SATB1_N; N-terminal domain of SATB1 and similar proteins
    pfam02376
    Location:484 → 563
    CUT; CUT domain
    pfam16557
    Location:169 → 239
    CUTL; CUT1-like DNA-binding domain of SATB

  2. XM_036163326.1 → XP_036019219.1  DNA-binding protein SATB2 isoform X2

    UniProtKB/TrEMBL
    H3BKH3
    Conserved Domains (4) summary
    smart00389
    Location:556 → 613
    HOX; Homeodomain
    cd11585
    Location:2 → 97
    SATB1_N; N-terminal domain of SATB1 and similar proteins
    pfam02376
    Location:419 → 498
    CUT; CUT domain
    pfam16557
    Location:104 → 174
    CUTL; CUT1-like DNA-binding domain of SATB

  3. XM_030252735.2 → XP_030108595.1  DNA-binding protein SATB2 isoform X1

    UniProtKB/TrEMBL
    H3BKH3
    Conserved Domains (4) summary
    smart00389
    Location:621 → 678
    HOX; Homeodomain
    cd11585
    Location:67 → 162
    SATB1_N; N-terminal domain of SATB1 and similar proteins
    pfam02376
    Location:484 → 563
    CUT; CUT domain
    pfam16557
    Location:169 → 239
    CUTL; CUT1-like DNA-binding domain of SATB
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VI24.1 GenPept UniProtKB/Swiss-Prot:Q8VI24

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