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Rsrc2 arginine/serine-rich coiled-coil 2 [ Mus musculus (house mouse) ]

Gene ID: 208606, updated on 5-Mar-2024

Summary

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Official Symbol
Rsrc2provided by MGI
Official Full Name
arginine/serine-rich coiled-coil 2provided by MGI
Primary source
MGI:MGI:1913489
See related
Ensembl:ENSMUSG00000029422 AllianceGenome:MGI:1913489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500011J06Rik
Summary
Is expressed in embryo. Orthologous to human RSRC2 (arginine and serine rich coiled-coil 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 41.6), CNS E14 (RPKM 26.5) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 63.15 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123866489..123887522, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123728426..123749429, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger, CCHC domain containing 8 Neighboring gene STARR-seq mESC enhancer starr_14326 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E104 Neighboring gene kinetochore associated 1 Neighboring gene hydroxycarboxylic acid receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Diversification of stem cell molecular repertoire by alternative splicing. Pritsker M, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183747, Free PMC Article
  2. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
  3. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  4. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
arginine/serine-rich coiled-coil protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005525.2 → NP_001005525.1  arginine/serine-rich coiled-coil protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC129582, AW557796, BC132550, BP772863
    Consensus CDS
    CCDS39271.1
    UniProtKB/TrEMBL
    S4R2L4
    Related
    ENSMUSP00000138691.2, ENSMUST00000182309.8
    Conserved Domains (1) summary
    pfam15477
    Location:354 → 423
    SMAP; Small acidic protein family

  2. NM_001359860.1 → NP_001346789.1  arginine/serine-rich coiled-coil protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 2 and 4, encodes isoform 2.
    Source sequence(s)
    AC129582
    Consensus CDS
    CCDS39272.1
    UniProtKB/Swiss-Prot
    A2RTL5
    Conserved Domains (1) summary
    pfam15477
    Location:296 → 365
    SMAP; Small acidic protein family

  3. NM_001359861.1 → NP_001346790.1  arginine/serine-rich coiled-coil protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform 2.
    Source sequence(s)
    AC129582
    Consensus CDS
    CCDS39272.1
    UniProtKB/Swiss-Prot
    A2RTL5
    Related
    ENSMUSP00000050563.8, ENSMUST00000050827.14
    Conserved Domains (1) summary
    pfam15477
    Location:296 → 365
    SMAP; Small acidic protein family

  4. NM_001359864.1 → NP_001346793.1  arginine/serine-rich coiled-coil protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC129582
    Conserved Domains (1) summary
    pfam15477
    Location:353 → 422
    SMAP; Small acidic protein family

  5. NM_001359865.1 → NP_001346794.1  arginine/serine-rich coiled-coil protein 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform 4.
    Source sequence(s)
    AC129582
    UniProtKB/TrEMBL
    B7ZNU2
    Conserved Domains (1) summary
    pfam15477
    Location:295 → 364
    SMAP; Small acidic protein family

  6. NM_001359866.1 → NP_001346795.1  arginine/serine-rich coiled-coil protein 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform 4.
    Source sequence(s)
    AC129582
    UniProtKB/TrEMBL
    B7ZNU2
    Conserved Domains (1) summary
    pfam15477
    Location:295 → 364
    SMAP; Small acidic protein family

  7. NM_025438.2 → NP_079714.1  arginine/serine-rich coiled-coil protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1. Variants 2, 3, and 4 all encode the same isoform (2).
    Source sequence(s)
    AC129582, BP772863
    Consensus CDS
    CCDS39272.1
    UniProtKB/Swiss-Prot
    A2RTL5
    Related
    ENSMUSP00000049942.6, ENSMUST00000057795.12
    Conserved Domains (1) summary
    pfam15477
    Location:296 → 365
    SMAP; Small acidic protein family

RNA

  1. NR_153355.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129582

  2. NR_153356.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129582

  3. NR_153357.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129582

  4. NR_153358.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129582

  5. NR_153359.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129582

  6. NR_153360.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129582

  7. NR_153361.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129582

  8. NR_153362.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129582

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    123866489..123887522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530244.5 → XP_006530307.1  arginine/serine-rich coiled-coil protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15477
    Location:306 → 375
    SMAP; Small acidic protein family

  2. XM_006530241.5 → XP_006530304.1  arginine/serine-rich coiled-coil protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530304.1

    UniProtKB/TrEMBL
    S4R265
    Conserved Domains (1) summary
    pfam15477
    Location:307 → 376
    SMAP; Small acidic protein family

  3. XM_011248190.4 → XP_011246492.1  arginine/serine-rich coiled-coil protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011246492.1

    UniProtKB/TrEMBL
    B7ZNU2
    Conserved Domains (1) summary
    pfam15477
    Location:295 → 364
    SMAP; Small acidic protein family

  4. XM_006530242.5 → XP_006530305.1  arginine/serine-rich coiled-coil protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530305.1

    UniProtKB/TrEMBL
    S4R265
    Related
    ENSMUSP00000138518.2, ENSMUST00000182489.8
    Conserved Domains (1) summary
    pfam15477
    Location:307 → 376
    SMAP; Small acidic protein family

  5. XM_006530243.5 → XP_006530306.1  arginine/serine-rich coiled-coil protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530306.1

    UniProtKB/TrEMBL
    S4R265
    Conserved Domains (1) summary
    pfam15477
    Location:307 → 376
    SMAP; Small acidic protein family

RNA

  1. XR_004942474.1 RNA Sequence

  2. XR_001784647.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001005523.1: Suppressed sequence

    Description
    NM_001005523.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RTL5.1 GenPept UniProtKB/Swiss-Prot:A2RTL5

Gene LinkOut

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