U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp143 zinc finger protein 143 [ Mus musculus (house mouse) ]

Gene ID: 20841, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp143provided by MGI
Official Full Name
zinc finger protein 143provided by MGI
Primary source
MGI:MGI:1277969
See related
Ensembl:ENSMUSG00000061079 AllianceGenome:MGI:1277969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SBF; Staf; Zfp79; pHZ-1; KRAB14; Znf143; Zfp80-rs1; D7Ertd805e
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of smooth muscle cell proliferation and positive regulation of snRNA transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PcG protein complex and transcription regulator complex. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF143 (zinc finger protein 143). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 6.7), CNS E11.5 (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zfp143 in Genome Data Viewer
Location:
7 E3; 7 57.7 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109660898..109694603)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110061689..110095396)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25636 Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene STARR-seq mESC enhancer starr_19814 Neighboring gene STARR-seq mESC enhancer starr_19815 Neighboring gene STARR-positive B cell enhancer ABC_E293 Neighboring gene STARR-positive B cell enhancer ABC_E6584 Neighboring gene WEE 1 homolog 1 (S. pombe) Neighboring gene VISTA enhancer mm725 Neighboring gene STARR-seq mESC enhancer starr_19821 Neighboring gene predicted gene, 51505

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genomic organization, chromosomal mapping and promoter analysis of the mouse selenocysteine tRNA gene transcription-activating factor (mStaf) gene. Adachi K, et al. Biochem J, 2000 Feb 15. PMID 10657238, Free PMC Article
  2. Molecular cloning and characterization of the murine staf cDNA encoding a transcription activating factor for the selenocysteine tRNA gene in mouse mammary gland. Adachi K, et al. J Biol Chem, 1998 Apr 10. PMID 9535833
  3. ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function. Zhou Q, et al. Nat Commun, 2021 Jan 4. PMID 33397967, Free PMC Article
  4. Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11. Ngondo-Mbongo RP, et al. Nucleic Acids Res, 2013 Apr. PMID 23408857, Free PMC Article
  5. The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice. Carlson BA, et al. Biochem J, 2009 Feb 15. PMID 18973473, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway.
    Title: ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway.
  2. ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function.
    Title: ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function.
  3. Zfp143 regulates Nanog expression through modulation of Oct4 binding.
    Title: Zfp143 regulates Nanog through modulation of Oct4 binding.
  4. STAF influences selenoprotein expression by enhancing Sec tRNA gene synthesis in an organ-specific manner
    Title: The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of snRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 143
Names
mStaf
selenocysteine tRNA gene transcription-activating factor
zfp-143
zinc finger protein 80, related sequence 1
NP_001361547.1
NP_001392700.1
NP_001392701.1
NP_033307.2
XP_036008747.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374618.1 → NP_001361547.1  zinc finger protein 143 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244
    Consensus CDS
    CCDS90307.1
    UniProtKB/Swiss-Prot
    O70230, Q8BGB0, Q8CEI6, Q8CI27
    Related
    ENSMUSP00000081778.5, ENSMUST00000084727.11
    Conserved Domains (3) summary
    COG5048
    Location:251 → 424
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:207 → 292
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001405771.1 → NP_001392700.1  zinc finger protein 143 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244
    UniProtKB/Swiss-Prot
    O70230, Q8BGB0, Q8CEI6, Q8CI27

  3. NM_001405772.1 → NP_001392701.1  zinc finger protein 143 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244

  4. NM_009281.4 → NP_033307.2  zinc finger protein 143 isoform 2

    See identical proteins and their annotated locations for NP_033307.2

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244
    Consensus CDS
    CCDS57580.1
    UniProtKB/Swiss-Prot
    O70230
    Related
    ENSMUSP00000148235.2, ENSMUST00000211798.2
    Conserved Domains (3) summary
    COG5048
    Location:250 → 423
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:206 → 291
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    109660898..109694603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152854.1 → XP_036008747.1  zinc finger protein 143 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:48 → 221
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:4 → 89
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:36 → 58
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70230.2 GenPept UniProtKB/Swiss-Prot:O70230

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous