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Ro60 Ro60, Y RNA binding protein [ Mus musculus (house mouse) ]

Gene ID: 20822, updated on 18-Apr-2024

Summary

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Official Symbol
Ro60provided by MGI
Official Full Name
Ro60, Y RNA binding proteinprovided by MGI
Primary source
MGI:MGI:106652
See related
Ensembl:ENSMUSG00000018199 AllianceGenome:MGI:106652
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ssa; Ssa2; Trove2; SS-A/Ro; 1810007I17Rik; A530054J02Rik
Summary
Enables U2 snRNA binding activity. Acts upstream of or within several processes, including cilium assembly; response to UV; and smoothened signaling pathway. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in embryo. Used to study systemic lupus erythematosus. Orthologous to human RO60 (Ro60, Y RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 5.5), CNS E18 (RPKM 5.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 F; 1 62.54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143626528..143652794, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143750790..143777063, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02529 Neighboring gene predicted gene, 38658 Neighboring gene predicted gene, 46161 Neighboring gene glutaredoxin 2 Neighboring gene STARR-positive B cell enhancer ABC_E1564 Neighboring gene STARR-positive B cell enhancer ABC_E2564 Neighboring gene predicted gene, 25663 Neighboring gene STARR-positive B cell enhancer ABC_E499 Neighboring gene ubiquitin carboxyl-terminal esterase L5 Neighboring gene STARR-seq mESC enhancer starr_02532 Neighboring gene STARR-positive B cell enhancer ABC_E5813 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:145766106-145766315 Neighboring gene predicted gene, 41964 Neighboring gene STARR-seq mESC enhancer starr_02533

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ro60 Inhibits Colonic Inflammation and Fibrosis in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis. Kim SY, et al. Immunol Lett, 2018 Sep. PMID 30395870
  2. Passive transfer of antibodies to the linear epitope 60 kD Ro 273-289 induces features of Sjögren's syndrome in naive mice. Maier-Moore JS, et al. Clin Exp Immunol, 2015 Apr. PMID 25370295, Free PMC Article
  3. Immunization with peptides from 60 kDa Ro in diverse mouse strains. Scofield RH, et al. Scand J Immunol, 2002 Nov. PMID 12410797
  4. Characterization and genomic sequence of the murine 60 kD Ro gene. Kaufman KM, et al. Genes Immun, 2000. PMID 11196703
  5. Immunization of mice with human 60-kd Ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse. Scofield RH, et al. Arthritis Rheum, 1999 May. PMID 10323459

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus.
    Title: IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus.
  2. Ro60 ameliorated the severity of dextran sodium sulfate -induced colitis in mice by repressing inflammation, fibrosis, angiogenesis, and the production of reactive oxygen species
    Title: Ro60 Inhibits Colonic Inflammation and Fibrosis in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis.
  3. These data support the hypothesis that antibodies to Ro274 deposit in salivary glands can enter intact salivary gland cells and are involved in the dysregulation of salivary flow in SS.
    Title: Passive transfer of antibodies to the linear epitope 60 kD Ro 273-289 induces features of Sjögren's syndrome in naive mice.
  4. Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity.
    Title: Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity.
  5. differences in the epitope spreading after 60 kDa Ro peptide immunization in several strains of mice
    Title: Immunization with peptides from 60 kDa Ro in diverse mouse strains.
  6. Ro protein has a role in preventing an autoimmune syndrome characterized by anti-ribosome antibodies, anti-chromatin antibodies, and glomerulonephritis
    Title: A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U2 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables misfolded RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immune system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to UV IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein Ro60
Names
60 kDa Ro protein
60 kDa SS-A/Ro ribonucleoprotein
60 kDa ribonucleoprotein Ro
Sjogren syndrome antigen A2
TROVE domain family, member 2
roRNP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013835.2 → NP_038863.1  RNA-binding protein Ro60

    See identical proteins and their annotated locations for NP_038863.1

    Status: VALIDATED

    Source sequence(s)
    AL592403, BQ032951, BY121097, U66843
    Consensus CDS
    CCDS15345.1
    UniProtKB/Swiss-Prot
    O08848, Q9QYD8
    UniProtKB/TrEMBL
    Q3TJ75, Q7TT40, Q80W12, Q8R562
    Related
    ENSMUSP00000125623.2, ENSMUST00000159879.2
    Conserved Domains (2) summary
    cd00198
    Location:372 → 489
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam05731
    Location:16 → 369
    TROVE; TROVE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    143626528..143652794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319451.3 → XP_017174940.1  RNA-binding protein Ro60 isoform X1

    UniProtKB/Swiss-Prot
    O08848, Q9QYD8
    UniProtKB/TrEMBL
    Q3TJ75, Q7TT40, Q80W12, Q8R562
    Conserved Domains (2) summary
    cd00198
    Location:372 → 489
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam05731
    Location:16 → 369
    TROVE; TROVE domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08848.1 GenPept UniProtKB/Swiss-Prot:O08848

Gene LinkOut

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