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Spop speckle-type BTB/POZ protein [ Mus musculus (house mouse) ]

Gene ID: 20747, updated on 5-Mar-2024

Summary

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Official Symbol
Spopprovided by MGI
Official Full Name
speckle-type BTB/POZ proteinprovided by MGI
Primary source
MGI:MGI:1343085
See related
Ensembl:ENSMUSG00000057522 AllianceGenome:MGI:1343085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TEF2; Pcif1
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including glucose homeostasis; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Located in nuclear speck. Is expressed in lung; metanephros; and pancreas. Orthologous to human SPOP (speckle type BTB/POZ protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 32.0), bladder adult (RPKM 30.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Spop in Genome Data Viewer
Location:
11 D; 11 59.01 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95304909..95384236)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95414083..95493410)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 117, member A Neighboring gene STARR-positive B cell enhancer ABC_E3009 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:95253828-95254029 Neighboring gene STARR-seq mESC enhancer starr_30505 Neighboring gene solute carrier family 35, member B1 Neighboring gene STARR-positive B cell enhancer ABC_E3010 Neighboring gene STARR-positive B cell enhancer ABC_E10708 Neighboring gene predicted gene, 53646 Neighboring gene neurexophilin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The diverse roles of SPOP in prostate cancer and kidney cancer. Wang Z, et al. Nat Rev Urol, 2020 Jun. PMID 32355326
  2. SPOP and cancer: a systematic review. Clark A, et al. Am J Cancer Res, 2020. PMID 32266086, Free PMC Article
  3. The emerging role of SPOP protein in tumorigenesis and cancer therapy. Song Y, et al. Mol Cancer, 2020 Jan 4. PMID 31901237, Free PMC Article
  4. The ubiquitin ligase adaptor SPOP in cancer. Cuneo MJ, et al. FEBS J, 2019 Oct. PMID 31495053, Free PMC Article
  5. The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation. Guillamot M, et al. Nat Immunol, 2019 Sep. PMID 31406379, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction.
    Title: Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction.
  2. Spop ameliorates diabetic nephropathy through restraining NLRP3 inflammasome.
    Title: Spop ameliorates diabetic nephropathy through restraining NLRP3 inflammasome.
  3. CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.
    Title: CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.
  4. Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.
    Title: Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.
  5. SPOP is a key regulator of emergency hematopoiesis and inflammation sensing in the bone marrow.
    Title: The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation.
  6. SPOP is required for embryo implantation, endometrial decidualization, and uterine health in the mouse
    Title: Uterine function in the mouse requires speckle-type poz protein.
  7. no evidence that ERG is an effector of SPOP mutation in human prostate cancer or mouse models.
    Title: SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG.
  8. loss of Spop, but not Spopl, disrupts chondrocyte hypertrophy and osteoblast differentiation in the mouse, suggesting the requirement for Spop-mediated protein degradation in mouse skeletal development; overexpressed Spop targets both Gli3FL and Gli3R for ubiquitination and degradation and Spop is an important positive regulator of Ihh signaling and skeletal development
    Title: Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling.
  9. Results demonstrate a negative role of Spop in the level and activity of Gli3, Shh signaling and ventral spinal cord patterning.
    Title: Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord.
  10. Speckle-type pox virus and zinc finger (POZ) protein (SPOP) regulates endometrial stromal cell decidualization in mice and that hormones regulate the expression of SPOP. This study suggests that ubiquitination may be involved in embryonic implantation.
    Title: SPOP Regulates Endometrial Stromal Cell Decidualization in Mice.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glucose homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of type B pancreatic cell apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of type B pancreatic cell apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
speckle-type POZ protein
Names
HIB homolog 1
PDX-1 C-terminal-interacting factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359107.1 → NP_001346036.1  speckle-type POZ protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK132383, BF662657, BY172312
    Consensus CDS
    CCDS36286.1
    UniProtKB/Swiss-Prot
    Q3TLC2, Q5ST07, Q6ZWS8, Q76LV9
    UniProtKB/TrEMBL
    Q3THQ1
    Related
    ENSMUSP00000103350.2, ENSMUST00000107722.8
    Conserved Domains (3) summary
    cd03774
    Location:28 → 166
    MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
    cd18279
    Location:182 → 301
    BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
    cd18518
    Location:297 → 367
    BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

  2. NM_025287.2 → NP_079563.2  speckle-type POZ protein

    See identical proteins and their annotated locations for NP_079563.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB071989, AK004669, BY303667, BY726358, CJ207806
    Consensus CDS
    CCDS36286.1
    UniProtKB/Swiss-Prot
    Q3TLC2, Q5ST07, Q6ZWS8, Q76LV9
    UniProtKB/TrEMBL
    Q3THQ1
    Related
    ENSMUSP00000103352.3, ENSMUST00000107724.9
    Conserved Domains (3) summary
    cd03774
    Location:28 → 166
    MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
    cd18279
    Location:182 → 301
    BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
    cd18518
    Location:297 → 367
    BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    95304909..95384236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZWS8.1 GenPept UniProtKB/Swiss-Prot:Q6ZWS8

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