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Snrpb small nuclear ribonucleoprotein B [ Mus musculus (house mouse) ]

Gene ID: 20638, updated on 11-Apr-2024

Summary

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Official Symbol
Snrpbprovided by MGI
Official Full Name
small nuclear ribonucleoprotein Bprovided by MGI
Primary source
MGI:MGI:98342
See related
Ensembl:ENSMUSG00000027404 AllianceGenome:MGI:98342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SMB; SM-B; SM11; SNRNP-B
Summary
Enables histone pre-mRNA DCP binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to act upstream of or within protein methylation. Located in cytoplasm and nucleus. Part of histone pre-mRNA 3'end processing complex. Is expressed in several structures, including branchial arch; central nervous system; limb; maxillary process; and sensory organ. Human ortholog(s) of this gene implicated in cerebrocostomandibular syndrome and mixed connective tissue disease. Orthologous to human SNRPB (small nuclear ribonucleoprotein polypeptides B and B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 137.1), adrenal adult (RPKM 133.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 63.19 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130013560..130031184, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130171636..130179382, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene expressed sequence AU015228 Neighboring gene transglutaminase 6 Neighboring gene STARR-positive B cell enhancer ABC_E2047 Neighboring gene transmembrane channel-like gene family 2 Neighboring gene STARR-seq mESC enhancer starr_05689 Neighboring gene STARR-seq mESC enhancer starr_05690 Neighboring gene STARR-positive B cell enhancer ABC_E643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130100530-130100713 Neighboring gene small nucleolar RNA, C/D box 110 Neighboring gene NOP56 ribonucleoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer. Liu N, et al. Med Oncol, 2021 Apr 9. PMID 33835288
  2. Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos. Turner BRH, et al. Dev Dyn, 2023 Feb. PMID 36058892, Free PMC Article
  3. Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing. Larsson SH, et al. Cell, 1995 May 5. PMID 7736591
  4. Comparison of the Drosophila melanogaster, human and murine Sm B cDNAs: evolutionary conservation. Brunet C, et al. Gene, 1993 Feb 28. PMID 7680326
  5. The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site. Griffith AJ, et al. Gene, 1992 May 15. PMID 1376292

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos.
    Title: Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos.
  2. Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis.
    Title: Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis.
  3. SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer.
    Title: SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U1 snRNP binding ISO
Inferred from Sequence Orthology
more info
  
enables U2 snRNP binding ISO
Inferred from Sequence Orthology
more info
  
enables histone pre-mRNA DCP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables snRNP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein methylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SMN-Sm protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U1 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of U12-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U4 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U7 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone pre-mRNA 3'end processing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of methylosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small nuclear ribonucleoprotein-associated protein B
Names
sm protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412650.1 → NP_001399579.1  small nuclear ribonucleoprotein-associated protein B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL833804

  2. NM_001412651.1 → NP_001399580.1  small nuclear ribonucleoprotein-associated protein B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL833804

  3. NM_001412652.1 → NP_001399581.1  small nuclear ribonucleoprotein-associated protein B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL833804

  4. NM_001412653.1 → NP_001399582.1  small nuclear ribonucleoprotein-associated protein B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL833804

  5. NM_001412654.1 → NP_001399583.1  small nuclear ribonucleoprotein-associated protein B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL833804

  6. NM_001412655.1 → NP_001399584.1  small nuclear ribonucleoprotein-associated protein B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL833804

  7. NM_001412656.1 → NP_001399585.1  small nuclear ribonucleoprotein-associated protein B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL833804

  8. NM_001412657.1 → NP_001399586.1  small nuclear ribonucleoprotein-associated protein B isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL833804

  9. NM_001412658.1 → NP_001399587.1  small nuclear ribonucleoprotein-associated protein B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL833804

  10. NM_001412659.1 → NP_001399588.1  small nuclear ribonucleoprotein-associated protein B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL833804

  11. NM_001420982.1 → NP_001407911.1  small nuclear ribonucleoprotein-associated protein B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL833804

  12. NM_009225.3 → NP_033251.1  small nuclear ribonucleoprotein-associated protein B isoform 1

    See identical proteins and their annotated locations for NP_033251.1

    Status: VALIDATED

    Source sequence(s)
    AL833804
    Consensus CDS
    CCDS16735.1
    UniProtKB/Swiss-Prot
    P27048, Q3UJT1
    UniProtKB/TrEMBL
    O70499
    Related
    ENSMUSP00000099488.5, ENSMUST00000103199.9
    Conserved Domains (1) summary
    cd01717
    Location:5 → 83
    Sm_B; Sm protein B

RNA

  1. NR_182019.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL833804

  2. NR_182020.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL833804
    Related
    ENSMUST00000147570.3

  3. NR_182021.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL833804

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    130013560..130031184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159932.1 → XP_036015825.1  small nuclear ribonucleoprotein-associated protein B isoform X1

    UniProtKB/Swiss-Prot
    P27048, Q3UJT1
    UniProtKB/TrEMBL
    O70499
    Conserved Domains (1) summary
    cd01717
    Location:5 → 83
    Sm_B; Sm protein B
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27048.1 GenPept UniProtKB/Swiss-Prot:P27048

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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