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Snrnp70 small nuclear ribonucleoprotein 70 (U1) [ Mus musculus (house mouse) ]

Gene ID: 20637, updated on 5-Mar-2024

Summary

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Official Symbol
Snrnp70provided by MGI
Official Full Name
small nuclear ribonucleoprotein 70 (U1)provided by MGI
Primary source
MGI:MGI:98341
See related
Ensembl:ENSMUSG00000063511 AllianceGenome:MGI:98341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U1-70; Snrp70; Srnp70; U1-70K; Rnu1p70; Rnulp70; 2700022N21Rik; 3200002N22Rik
Summary
This gene encodes a subunit of the U1 snRNP (small nuclear ribonucleic particle), one of at least five snRNPs to comprise the spliceosome, which functions in processing of pre-mRNAs. The U1 snRNP has been shown to be important in defining the 5' splice site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 132.4), thymus adult (RPKM 114.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 29.28 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45025878..45045177, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45376454..45395742, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 Neighboring gene STARR-positive B cell enhancer ABC_E2237 Neighboring gene STARR-positive B cell enhancer ABC_E700 Neighboring gene STARR-positive B cell enhancer ABC_E11352 Neighboring gene metastasis associated gene 2 Neighboring gene lin-7 homolog B, crumbs cell polarity complex component Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52651210-52651456 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 7 Neighboring gene neurotrophin 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. Query CC, et al. Cell, 1987 Oct 23. PMID 2959371
  2. Analysis of genomic clones of the murine U1RNA-associated 70-kDa protein reveals a high evolutionary conservation of the protein between human and mouse. Hornig H, et al. Eur J Biochem, 1989 Jun 1. PMID 2525092
  3. Dissection of FUS domains involved in regulation of SnRNP70 gene expression. Nakaya T. FEBS Lett, 2020 Nov. PMID 32915994
  4. Exon-specific U1 snRNAs improve ELP1 exon 20 definition and rescue ELP1 protein expression in a familial dysautonomia mouse model. Donadon I, et al. Hum Mol Genet, 2018 Jul 15. PMID 29701768, Free PMC Article
  5. Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Cho S, et al. Proc Natl Acad Sci U S A, 2011 May 17. PMID 21536904, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dissection of FUS domains involved in regulation of SnRNP70 gene expression.
    Title: Dissection of FUS domains involved in regulation of SnRNP70 gene expression.
  2. SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing.
    Title: SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing.
  3. This splice-switching class of molecules is the first to specifically correct the ELP1 exon 20 splicing defect. Our data provide proof of principle of ExSpeU1s-adeno-associated virus particles as a novel therapeutic strategy for FD.
    Title: Exon-specific U1 snRNAs improve ELP1 exon 20 definition and rescue ELP1 protein expression in a familial dysautonomia mouse model.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U1 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U1 snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U1 snRNP binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U1 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U1 small nuclear ribonucleoprotein 70 kDa
Names
U1 small nuclear ribonucleoprotein 70 kDa polypeptide A
U1 snRNP 70 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009224.6 → NP_033250.3  U1 small nuclear ribonucleoprotein 70 kDa

    See identical proteins and their annotated locations for NP_033250.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the protein.
    Source sequence(s)
    AC151602
    Consensus CDS
    CCDS21240.1
    UniProtKB/Swiss-Prot
    Q3UIW4, Q62376
    UniProtKB/TrEMBL
    A2RS68
    Related
    ENSMUSP00000074160.8, ENSMUST00000074575.11
    Conserved Domains (2) summary
    cd12236
    Location:102 → 187
    RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
    pfam12220
    Location:3 → 93
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal

RNA

  1. NR_126538.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC151602
    Related
    ENSMUST00000211290.2

  2. NR_126539.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC151602
    Related
    ENSMUST00000211366.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45025878..45045177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152829.1 → XP_036008722.1  U1 small nuclear ribonucleoprotein 70 kDa isoform X2

    UniProtKB/TrEMBL
    A0A1B0GRR8, Q6ZWP0
    Conserved Domains (2) summary
    pfam12220
    Location:3 → 93
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
    cl17169
    Location:102 → 164
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_036152830.1 → XP_036008723.1  U1 small nuclear ribonucleoprotein 70 kDa isoform X2

    UniProtKB/TrEMBL
    A0A1B0GRR8, Q6ZWP0
    Related
    ENSMUSP00000147636.2, ENSMUST00000209858.2
    Conserved Domains (2) summary
    pfam12220
    Location:3 → 93
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
    cl17169
    Location:102 → 164
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_036152827.1 → XP_036008720.1  U1 small nuclear ribonucleoprotein 70 kDa isoform X1

    Conserved Domains (2) summary
    pfam12220
    Location:3 → 93
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
    cd12236
    Location:102 → 192
    RRM_snRNP70; RNA recognition motif (RRM) found in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins

  4. XM_011250831.3 → XP_011249133.1  U1 small nuclear ribonucleoprotein 70 kDa isoform X1

    See identical proteins and their annotated locations for XP_011249133.1

    Conserved Domains (2) summary
    pfam12220
    Location:3 → 93
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
    cd12236
    Location:102 → 192
    RRM_snRNP70; RNA recognition motif (RRM) found in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins

  5. XM_036152828.1 → XP_036008721.1  U1 small nuclear ribonucleoprotein 70 kDa isoform X1

    Conserved Domains (2) summary
    pfam12220
    Location:3 → 93
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
    cd12236
    Location:102 → 192
    RRM_snRNP70; RNA recognition motif (RRM) found in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62376.2 GenPept UniProtKB/Swiss-Prot:Q62376

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