Skil SKI-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Skilprovided by MGI
Official Full Name: SKI-likeprovided by MGI
Primary source: MGI:MGI:106203
See related: Ensembl:ENSMUSG00000027660 AllianceGenome:MGI:106203
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sno; Skir; SnoN
Summary: This gene encodes a member of a small family of proteins that play a key role in the response of cells to extracellular growth signals. The encoded protein regulates members of the transforming growth factor beta signaling pathway. It is highly expressed in certain cancer cells, where it may have both tumor-suppressing and tumor-promoting roles. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 8.0), CNS E18 (RPKM 5.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 15.12 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (31149259..31176741)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (31095058..31122923)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization.
Title: NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization.
Arkadia-SKI/SnoN signaling differentially regulates TGF-beta-induced iTreg and Th17 cell differentiation.
Title: Arkadia-SKI/SnoN signaling differentially regulates TGF-β-induced iTreg and Th17 cell differentiation.
SnoN has been implicated in distinct aspects of the development of postmitotic neurons, this study identifies a novel function for SnoN in neuronal precursors in the mammalian brain
Title: The Transcriptional Regulator SnoN Promotes the Proliferation of Cerebellar Granule Neuron Precursors in the Postnatal Mouse Brain.
SnoN plays an important in vivo role in adipocyte differentiation and white adipose tissue development in vivo by decreasing activity in the activin/Smad2 signaling pathway.
Title: The regulatory protein SnoN antagonizes activin/Smad2 protein signaling and thereby promotes adipocyte differentiation and obesity in mice.
Loss of SnoN is associated with partial embryonic lethality, mostly due to defects in angiogenesis in both the yolk sac and embryo body
Title: SnoN facilitates ALK1-Smad1/5 signaling during embryonic angiogenesis.
SnoN mediates a negative feedback mechanism evoked by TGF-beta to inhibit BMP signaling and, subsequently, hypertrophic maturation of chondrocytes.
Title: SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.
SnoN, a negative regulator of TGF-beta signaling, coordinates TGF-beta and prolactin signaling to control alveologenesis and lactogenesis.
Title: SnoN regulates mammary gland alveologenesis and onset of lactation by promoting prolactin/Stat5 signaling.
mRNA for positive regulators of Fshb expression, such as Fos and Jun, were up-regulated at slower pulse frequencies than a number of potential negative regulators, such as the corepressors Skil, Crem, and Tgif1.
Title: Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1.
The endogenous SnoN plays a role in regulating ADAM12 expression in response to TGFbeta1.
Title: The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12.
The authors conclude that somatic and germ cells at all differentiation stages are actively transducing TGFbeta superfamily signals but that responses to these ligands may be selectively modulated by SnoN2.
Title: Regulated production of SnoN2 is a feature of testicular differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Skil (e-PCR), detects polymorphism
- UniSTS:463225

U10532 (e-PCR)
- UniSTS:178822

NoName (e-PCR)
- UniSTS:234652

PMC165712P1 (e-PCR)
- UniSTS:271546

U10530 (e-PCR)
- UniSTS:125663

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of extrinsic apoptotic signaling pathway via death domain receptors	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens fiber cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lymphocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to growth factor	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ski-like protein

Names: ski-related oncogene; ski/sno related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039090.3 → NP_001034179.1 ski-like protein isoform b

See identical proteins and their annotated locations for NP_001034179.1

Status: REVIEWED

Source sequence(s)

AC117590

Consensus CDS

CCDS50886.1

UniProtKB/TrEMBL

Q3TB81, Q60979, Q64741

Related

ENSMUSP00000113256.2, ENSMUST00000118470.8

Conserved Domains (3) summary

smart01046
Location:258 → 353

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

TIGR02168
Location:481 → 620

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd21084
Location:134 → 233

DHD_Sno; Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins
NM_001271772.2 → NP_001258701.1 ski-like protein isoform c

Status: REVIEWED

Source sequence(s)

AC117590

Consensus CDS

CCDS71230.1

UniProtKB/TrEMBL

D3Z7C5, Q60979, Q64741

Related

ENSMUSP00000113054.2, ENSMUST00000117728.8

Conserved Domains (5) summary

smart01046
Location:178 → 273

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam01442
Location:402 → 540

Apolipoprotein; Apolipoprotein A1/A4/E domain

pfam02437
Location:53 → 152

Ski_Sno; SKI/SNO/DAC family

cd16269
Location:504 → 515

GBP_C; coiled coil [structural motif]

cl20817
Location:389 → 537

GBP_C; Guanylate-binding protein, C-terminal domain
NM_001398558.1 → NP_001385487.1 ski-like protein isoform a

Status: REVIEWED

Source sequence(s)

AC117590

UniProtKB/Swiss-Prot

Q60665, Q60702, Q78E90, Q80VK5

Conserved Domains (3) summary

smart01046
Location:258 → 353

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

TIGR02168
Location:527 → 666

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd21084
Location:134 → 233

DHD_Sno; Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins
NM_001398559.1 → NP_001385488.1 ski-like protein isoform b

Status: REVIEWED

Source sequence(s)

AC117590

UniProtKB/TrEMBL

Q3TB81

Conserved Domains (3) summary

smart01046
Location:258 → 353

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

TIGR02168
Location:481 → 620

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd21084
Location:134 → 233

DHD_Sno; Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins
NM_001398560.1 → NP_001385489.1 ski-like protein isoform b

Status: REVIEWED

Source sequence(s)

AC117590

Conserved Domains (3) summary

smart01046
Location:258 → 353

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

TIGR02168
Location:481 → 620

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd21084
Location:134 → 233

DHD_Sno; Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins
NM_011386.4 → NP_035516.2 ski-like protein isoform a

See identical proteins and their annotated locations for NP_035516.2

Status: REVIEWED

Source sequence(s)

AC117590

Consensus CDS

CCDS38408.1

UniProtKB/Swiss-Prot

Q60665, Q60702, Q78E90, Q80VK5

UniProtKB/TrEMBL

Q60979, Q64741

Related

ENSMUSP00000029194.6, ENSMUST00000029194.12

Conserved Domains (3) summary

smart01046
Location:258 → 353

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

TIGR02168
Location:527 → 666

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd21084
Location:134 → 233

DHD_Sno; Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins