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Sgk1 serum/glucocorticoid regulated kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 20393, updated on 21-Apr-2024

Summary

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Official Symbol
Sgk1provided by MGI
Official Full Name
serum/glucocorticoid regulated kinase 1provided by MGI
Primary source
MGI:MGI:1340062
See related
Ensembl:ENSMUSG00000019970 AllianceGenome:MGI:1340062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sgk
Summary
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq, Sep 2009]
Expression
Ubiquitous expression in colon adult (RPKM 16.7), large intestine adult (RPKM 16.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A3; 10 9.83 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (21758083..21875802)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (21882184..21999903)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene pluripotency associated transcript 6 Neighboring gene predicted gene, 46215 Neighboring gene predicted gene, 23839 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:21625509-21625692 Neighboring gene STARR-seq mESC enhancer starr_26005 Neighboring gene STARR-seq mESC enhancer starr_26006 Neighboring gene pyrophosphatase (inorganic) 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26009 Neighboring gene STARR-seq mESC enhancer starr_26010 Neighboring gene STARR-positive B cell enhancer mm9_chr10:21714242-21714543 Neighboring gene uncharacterized LOC118567833 Neighboring gene STARR-seq mESC enhancer starr_26012 Neighboring gene predicted gene 7672

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3. Li X, et al. J Transl Med, 2023 Feb 14. PMID 36788538, Free PMC Article
  2. Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1. Patel CH, et al. J Immunol, 2022 Dec 15. PMID 36469844, Free PMC Article
  3. Transcriptomic Profile Identifies Hippocampal Sgk1 as the Key Mediator of Ovarian Estrogenic Regulation on Spatial Learning and Memory and Aβ Accumulation. Liu M, et al. Neurochem Res, 2022 Nov. PMID 35915371
  4. SGK1 is essential for meiotic resumption in mammalian oocytes. Del Llano E, et al. Eur J Cell Biol, 2022 Apr. PMID 35240557, Free PMC Article
  5. Columbianetin alleviates lipopolysaccharides (LPS)-induced inflammation and apoptosis in chondrocyte through activation of autophagy by inhibiting serum and glucocorticoid-induced protein kinase 1 (SGK1) expression. Chen W, et al. Bioengineered, 2022 Feb. PMID 35129051, Free PMC Article

See all (222) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening.
    Title: Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening.
  2. SGLT2 knockdown restores the Th17/Treg balance and suppresses diabetic nephropathy in db/db mice by regulating SGK1 via Na.
    Title: SGLT2 knockdown restores the Th17/Treg balance and suppresses diabetic nephropathy in db/db mice by regulating SGK1 via Na().
  3. SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis.
    Title: SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis.
  4. SGK1 is involved in doxorubicin-induced chronic cardiotoxicity and dysfunction through activation of the NFkappaB pathway.
    Title: SGK1 is involved in doxorubicin-induced chronic cardiotoxicity and dysfunction through activation of the NFκB pathway.
  5. Renal tubular SGK1 is required to achieve blood pressure surge and circadian rhythm.
    Title: Renal tubular SGK1 is required to achieve blood pressure surge and circadian rhythm.
  6. Association between SGK1 and alpha-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model.
    Title: Association between SGK1 and α-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model.
  7. Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.
    Title: Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.
  8. Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1.
    Title: Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1.
  9. Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3.
    Title: Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3.
  10. Transcriptomic Profile Identifies Hippocampal Sgk1 as the Key Mediator of Ovarian Estrogenic Regulation on Spatial Learning and Memory and Abeta Accumulation.
    Title: Transcriptomic Profile Identifies Hippocampal Sgk1 as the Key Mediator of Ovarian Estrogenic Regulation on Spatial Learning and Memory and Aβ Accumulation.
Submit: New GeneRIF Correction See all GeneRIFs (154)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to aldosterone IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in glucocorticoid mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in visual learning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Sgk1
Names
serum and glucocorticoid-dependent protein kinase
NP_001155317.2
NP_001155319.1
NP_001155320.1
NP_001155321.1
NP_001155322.1
NP_035491.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161845.2 → NP_001155317.2  serine/threonine-protein kinase Sgk1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC070401, BY493368
    Consensus CDS
    CCDS48515.1
    UniProtKB/Swiss-Prot
    Q9WVC6
    Related
    ENSMUSP00000114074.2, ENSMUST00000120509.8
    Conserved Domains (2) summary
    smart00220
    Location:191 → 448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05602
    Location:183 → 521
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

  2. NM_001161847.2 → NP_001155319.1  serine/threonine-protein kinase Sgk1 isoform b

    See identical proteins and their annotated locations for NP_001155319.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC153555, AK159131, BY493368, CN709375
    Consensus CDS
    CCDS48518.1
    UniProtKB/TrEMBL
    E9Q8C1
    Related
    ENSMUSP00000128873.2, ENSMUST00000164659.8
    Conserved Domains (2) summary
    smart00220
    Location:71 → 328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05602
    Location:63 → 401
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

  3. NM_001161848.2 → NP_001155320.1  serine/threonine-protein kinase Sgk1 isoform b

    See identical proteins and their annotated locations for NP_001155320.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AK159131, BY493368, BY736002
    Consensus CDS
    CCDS48518.1
    UniProtKB/TrEMBL
    E9Q8C1
    Conserved Domains (2) summary
    smart00220
    Location:71 → 328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05602
    Location:63 → 401
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

  4. NM_001161849.2 → NP_001155321.1  serine/threonine-protein kinase Sgk1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK159131, BY493368, BY786122
    Consensus CDS
    CCDS48516.1
    UniProtKB/TrEMBL
    E9Q1B0
    Related
    ENSMUSP00000097614.4, ENSMUST00000100036.10
    Conserved Domains (1) summary
    cd05602
    Location:76 → 414
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

  5. NM_001161850.2 → NP_001155322.1  serine/threonine-protein kinase Sgk1 isoform d

    See identical proteins and their annotated locations for NP_001155322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK132234, BY493368, CK626189
    Consensus CDS
    CCDS48517.1
    UniProtKB/Swiss-Prot
    Q9WVC6
    Related
    ENSMUSP00000090343.5, ENSMUST00000092673.11
    Conserved Domains (1) summary
    cd05602
    Location:104 → 442
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

  6. NM_011361.3 → NP_035491.1  serine/threonine-protein kinase Sgk1 isoform e

    See identical proteins and their annotated locations for NP_035491.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC153555, AK159131, BY493368
    Consensus CDS
    CCDS23726.1
    UniProtKB/Swiss-Prot
    Q3TJN4, Q3UKD0, Q3UKF2, Q3V1V1, Q6NS85, Q9WVC6
    Related
    ENSMUSP00000020145.6, ENSMUST00000020145.12
    Conserved Domains (1) summary
    cd05602
    Location:90 → 428
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    21758083..21875802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVC6.1 GenPept UniProtKB/Swiss-Prot:Q9WVC6

Gene LinkOut

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