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Srsf5 serine and arginine-rich splicing factor 5 [ Mus musculus (house mouse) ]

Gene ID: 20384, updated on 5-Mar-2024

Summary

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Official Symbol
Srsf5provided by MGI
Official Full Name
serine and arginine-rich splicing factor 5provided by MGI
Primary source
MGI:MGI:98287
See related
Ensembl:ENSMUSG00000021134 AllianceGenome:MGI:98287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sfrs5
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Nov 2016]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 229.5), bladder adult (RPKM 197.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D1; 12 37.2 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80992308..80997277)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80945495..80950507)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700052I22 gene Neighboring gene STARR-positive B cell enhancer ABC_E4033 Neighboring gene STARR-positive B cell enhancer ABC_E5338 Neighboring gene predicted gene, 20337 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr12:82083313-82083614 Neighboring gene SPARC related modular calcium binding 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:82164637-82164838 Neighboring gene ribosomal protein S8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus. Li Q, et al. Adv Sci (Weinh), 2022 Dec. PMID 36257906, Free PMC Article
  2. Proteasome-mediated proteolysis of SRSF5 splicing factor intriguingly co-occurs with SRSF5 mRNA upregulation during late erythroid differentiation. Breig O, et al. PLoS One, 2013. PMID 23536862, Free PMC Article
  3. Transforming growth factor-beta1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation. Han F, et al. Exp Cell Res, 2007 May 1. PMID 17391668, Free PMC Article
  4. Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. Du K, et al. Gene, 1997 Dec 19. PMID 9434190
  5. Cellular differentiation state modulates the mRNA export activity of SR proteins. Botti V, et al. J Cell Biol, 2017 Jul 3. PMID 28592444, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus.
    Title: SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus.
  2. CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
    Title: CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
  3. Posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells.
    Title: Cellular differentiation state modulates the mRNA export activity of SR proteins.
  4. overexpression of SRSF5 enhances a specific endogenous pre-mRNA splicing event in proliferating cells, but not in differentiating cells, due to proteasome-mediated targeting of both endogenous and transfection-derived SRSF5.
    Title: Proteasome-mediated proteolysis of SRSF5 splicing factor intriguingly co-occurs with SRSF5 mRNA upregulation during late erythroid differentiation.
  5. the effects of TGF-beta1 on FN splicing during chondrogenesis may be largely dependent on its effect on SRp40 isoform expression
    Title: Transforming growth factor-beta1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation.
  6. Data show that Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of SRp40.
    Title: Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC96781

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RS domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase B binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to wounding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/arginine-rich splicing factor 5
Names
delayed-early protein HRS
pre-mRNA-splicing factor SRP40
splicing factor, arginine/serine-rich 5 (SRp40, HRS)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079694.3 → NP_001073162.1  serine/arginine-rich splicing factor 5 isoform 1

    See identical proteins and their annotated locations for NP_001073162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AA388848, AC125092, AK146624, BC082593
    Consensus CDS
    CCDS36484.1
    UniProtKB/Swiss-Prot
    O35326, Q640L9
    Related
    ENSMUSP00000131323.2, ENSMUST00000094693.11
    Conserved Domains (2) summary
    cd12595
    Location:5 → 74
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99 → 179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

  2. NM_001079695.3 → NP_001073163.1  serine/arginine-rich splicing factor 5 isoform 1

    See identical proteins and their annotated locations for NP_001073163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2 and 3 encode the same isoform.
    Source sequence(s)
    AA388848, AK146624, BY143979
    Consensus CDS
    CCDS36484.1
    UniProtKB/Swiss-Prot
    O35326, Q640L9
    Related
    ENSMUSP00000105985.3, ENSMUST00000110356.3
    Conserved Domains (2) summary
    cd12595
    Location:5 → 74
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99 → 179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

  3. NM_001347415.2 → NP_001334344.1  serine/arginine-rich splicing factor 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa longer than isoform 1. Variants 4, 5 and 10 encode the same isoform (2).
    Source sequence(s)
    AA388848, AK007729, BE989777, BY634333
    Consensus CDS
    CCDS83974.1
    UniProtKB/TrEMBL
    Q9D8S5
    Related
    ENSMUSP00000105980.2, ENSMUST00000110351.8
    Conserved Domains (2) summary
    cd12595
    Location:5 → 74
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99 → 179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

  4. NM_001347416.2 → NP_001334345.1  serine/arginine-rich splicing factor 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa longer than isoform 1. Variants 4, 5 and 10 encode the same isoform (2).
    Source sequence(s)
    AA388848, AK007729, AK146624, BY634333
    Consensus CDS
    CCDS83974.1
    UniProtKB/TrEMBL
    Q9D8S5
    Conserved Domains (2) summary
    cd12595
    Location:5 → 74
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99 → 179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

  5. NM_001409833.1 → NP_001396762.1  serine/arginine-rich splicing factor 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125092

  6. NM_001409834.1 → NP_001396763.1  serine/arginine-rich splicing factor 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125092

  7. NM_001409835.1 → NP_001396764.1  serine/arginine-rich splicing factor 5 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: Variants 8 and 9 encode the same isoform (5).
    Source sequence(s)
    AC125092

  8. NM_001409836.1 → NP_001396765.1  serine/arginine-rich splicing factor 5 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: Variants 8 and 9 encode the same isoform (5).
    Source sequence(s)
    AC125092

  9. NM_001409837.1 → NP_001396766.1  serine/arginine-rich splicing factor 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: Variants 4, 5 and 10 encode the same isoform (2).
    Source sequence(s)
    AC125092
    UniProtKB/TrEMBL
    Q9D8S5

  10. NM_009159.4 → NP_033185.2  serine/arginine-rich splicing factor 5 isoform 1

    See identical proteins and their annotated locations for NP_033185.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AA388848, AK146624
    Consensus CDS
    CCDS36484.1
    UniProtKB/Swiss-Prot
    O35326, Q640L9
    Related
    ENSMUSP00000105981.4, ENSMUST00000110352.10
    Conserved Domains (2) summary
    cd12595
    Location:5 → 74
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99 → 179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    80992308..80997277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35326.2 GenPept UniProtKB/Swiss-Prot:O35326

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