Ccl9 C-C motif chemokine ligand 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccl9provided by MGI
Official Full Name: C-C motif chemokine ligand 9provided by MGI
Primary source: MGI:MGI:104533
See related: Ensembl:ENSMUSG00000019122 AllianceGenome:MGI:104533
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CCF18; MRP-2; Scya9; Scya10
Summary: Predicted to enable CCR1 chemokine receptor binding activity; chemoattractant activity; and chemokine activity. Acts upstream of or within negative regulation of myoblast differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and limb. Orthologous to several human genes including CCL23 (C-C motif chemokine ligand 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 14.7), liver adult (RPKM 11.8) and 11 other tissues See more
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Genomic context

Location:: 11 C; 11 50.81 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (83463743..83469462, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (83572917..83578636, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In conclusion, Cxcl16 expressed in pancreatic acini contributes to the development of acinar cell necrosis through the induction of Ccl9 and subsequent neutrophil infiltration.
Title: Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice.
Plasma concentrations of CCL15, the human homolog of mouse CCL9, were elevated in a previously published cohort of 211 cGVHD patients compared with controls and associated with NRM. In a cohort of 792 patients, CCL15 measured at day +100 could not predict cGVHD occurring within the next 3 months with clinically relevant sensitivity/specificity.
Title: Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients.
CCL9 secreted by splenic macrophages induces a CCR1dependent accumulation of MDSCs.
Title: CCL9/CCR1 induces myeloid‑derived suppressor cell recruitment to the spleen in a murine H22 orthotopic hepatoma model.
we report that chemokine CCL9 was highly induced in Gr-1(+)CD11b(+) immature myeloid cells and in premetastatic lung in tumor-bearing mice
Title: CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ.
Plasmid codelivery of murine CCL19 and CCL28 enhanced Ag-specific systemic and mucosal Ab responses to HIV-1 gp140, augmented balanced Th1/Th2 responses, and increased lymphocyte subsets in various lymphoid tissues.
Title: CCL19 and CCL28 augment mucosal and systemic immune responses to HIV-1 gp140 by mobilizing responsive immunocytes into secondary lymph nodes and mucosal tissue.
Taken together the data presented strongly suggest that 4T1 mammary tumor cell invasion in vitro is promoted by D1 mesenchymal stem cell secretions, especially the chemokines CCL5 and CCL9.
Title: Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases.
There is protein-DNA interaction between ETV5 and Ccl9, suggesting that ETV5 might be a direct regulator of Ccl9 expression.
Title: ETV5 regulates sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance.
Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis.
Title: Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.
Results reveal the potential involvement of CCL9 and CCR1 in macrophage and microglial cells by CpG-ODNs and may help understanding the role of the chemokine/chemokine receptor pairs in macrophage/microglia under physiologic and pathologic conditions.
Title: CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia.
the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP
Title: ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (3)

General gene information

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Markers

Ccl9 (e-PCR), detects polymorphism
- UniSTS:498462

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Ccl9 (e-PCR), detects polymorphism
- UniSTS:498367

U15209 (e-PCR)
- UniSTS:125683

Scya9 (e-PCR), detects polymorphism
- UniSTS:144382

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR1 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-C motif chemokine 9

Names: MIP-1 gamma; chemokine (C-C motif) ligand 9; macrophage inflammatory protein 1-gamma; macrophage inflammatory protein-related protein 2; small inducible cytokine A10; small inducible cytokine A9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.