Ccl17 C-C motif chemokine ligand 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccl17provided by MGI
Official Full Name: C-C motif chemokine ligand 17provided by MGI
Primary source: MGI:MGI:1329039
See related: Ensembl:ENSMUSG00000031780 AllianceGenome:MGI:1329039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tarc; Abcd-2; Scya17; Scya17l
Summary: Predicted to enable CCR4 chemokine receptor binding activity and chemokine activity. Acts upstream of or within negative regulation of myoblast differentiation. Predicted to be active in extracellular space. Is expressed in Sertoli cell; central nervous system; hemolymphoid system; and retina. Orthologous to human CCL17 (C-C motif chemokine ligand 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 46.85 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (95535996..95538666)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94809380..94812038)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting Monocyte Derived CCL17 Attenuates Murine Crescentic Glomerulonephritis by Affecting Renal CCR4+ Regulatory T-Cell Recruitment.
Title: Targeting Monocyte Derived CCL17 Attenuates Murine Crescentic Glomerulonephritis by Affecting Renal CCR4+ Regulatory T-Cell Recruitment.
The GM-CSF/CCL17 pathway in obesity-associated osteoarthritic pain and disease in mice.
Title: The GM-CSF/CCL17 pathway in obesity-associated osteoarthritic pain and disease in mice.
CCL17 acts as an antitumor chemokine in micromilieu-driven immune skewing.
Title: CCL17 acts as an antitumor chemokine in micromilieu-driven immune skewing.
CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF-beta/Smad signaling.
Title: CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF-β/Smad signaling.
CCL17 Protects Against Viral Myocarditis by Suppressing the Recruitment of Regulatory T Cells.
Title: CCL17 Protects Against Viral Myocarditis by Suppressing the Recruitment of Regulatory T Cells.
CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota.
Title: CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota.
TARC/CCL17 Expression Is Associated with CD8(+) T Cell Recruitment in Abacavir-Induced Skin Hypersensitivity in HLA-Transgenic Mice.
Title: TARC/CCL17 Expression Is Associated with CD8(+) T Cell Recruitment in Abacavir-Induced Skin Hypersensitivity in HLA-Transgenic Mice.
CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells.
Title: CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells.
Repeated exposure of house dust mite induces progressive airway inflammation in mice: Differential roles of CCL17 and IL-13.
Title: Repeated exposure of house dust mite induces progressive airway inflammation in mice: Differential roles of CCL17 and IL-13.
CCL17-expressing dendritic cells in the intestine are preferentially infected by Salmonella but CCL17 plays a redundant role in systemic dissemination.
Title: CCL17-expressing dendritic cells in the intestine are preferentially infected by Salmonella but CCL17 plays a redundant role in systemic dissemination.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (7) 1 citation

General gene information

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Markers

PMC152071P2 (e-PCR)
- UniSTS:271201

AJ242587 (e-PCR)
- UniSTS:163444

Ccl17 (e-PCR), detects polymorphism
- UniSTS:530813

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR4 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	TAS Traceable Author Statement more info	PubMed
enables cytokine activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell chemotaxis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular defense response	TAS Traceable Author Statement more info	PubMed
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-C motif chemokine 17

Names: CC chemokine TARC; chemokine (C-C motif) ligand 17; small inducible cytokine subfamily A17; small-inducible cytokine A17; thymus and activation-regulated chemokine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011332.3 → NP_035462.2 C-C motif chemokine 17 precursor

See identical proteins and their annotated locations for NP_035462.2

Status: VALIDATED

Source sequence(s)

AK007663, BC028505

Consensus CDS

CCDS57633.1

UniProtKB/Swiss-Prot

Q9R043, Q9WUZ6

UniProtKB/TrEMBL

F6R5P4

Related

ENSMUSP00000034232.2, ENSMUST00000034232.3

Conserved Domains (1) summary

cd00272
Location:43 → 99

Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

95535996..95538666

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530782.5 → XP_006530845.1 C-C motif chemokine 17 isoform X1

See identical proteins and their annotated locations for XP_006530845.1

UniProtKB/Swiss-Prot

Q9R043, Q9WUZ6

UniProtKB/TrEMBL

F6R5P4

Conserved Domains (1) summary

cd00272
Location:43 → 99

Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...