Scd1 stearoyl-Coenzyme A desaturase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scd1provided by MGI
Official Full Name: stearoyl-Coenzyme A desaturase 1provided by MGI
Primary source: MGI:MGI:98239
See related: Ensembl:ENSMUSG00000037071 AllianceGenome:MGI:98239
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ab; Scd; Scd-1
Summary: Enables metal ion binding activity; palmitoyl-CoA 9-desaturase activity; and stearoyl-CoA 9-desaturase activity. Involved in several processes, including cholesterol esterification; positive regulation of cold-induced thermogenesis; and tarsal gland development. Acts upstream of or within several processes, including brown fat cell differentiation; monounsaturated fatty acid biosynthetic process; and white fat cell differentiation. Is integral component of endoplasmic reticulum membrane. Is expressed in several structures, including adipose tissue; central nervous system; cranium; integumental system; and liver. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to several human genes including SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 3754.4), mammary gland adult (RPKM 3202.4) and 5 other tissues See more
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Genomic context

Location:: 19 C3; 19 37.98 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (44382889..44396148, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (44394450..44407709, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites.
Title: Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites.
SCD1 inhibition enhances the effector functions of CD8[+] T cells via ACAT1-dependent reduction of esterified cholesterol.
Title: SCD1 inhibition enhances the effector functions of CD8(+) T cells via ACAT1-dependent reduction of esterified cholesterol.
SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes.
Title: SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes.
Dynamic role of Scd1 gene during mouse oocyte growth and maturation.
Title: Dynamic role of Scd1 gene during mouse oocyte growth and maturation.
Stearoyl-CoA desaturase 1 deficiency exacerbates palmitate-induced lipotoxicity by the formation of small lipid droplets in pancreatic beta-cells.
Title: Stearoyl-CoA desaturase 1 deficiency exacerbates palmitate-induced lipotoxicity by the formation of small lipid droplets in pancreatic β-cells.
Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche.
Title: Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche.
SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes.
Title: SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes.
Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of beta-cell identity and alpha-cell expansion in the mature pancreas.
Title: Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas.
Effects of CRISPR/Cas9-mediated stearoyl-Coenzyme A desaturase 1 knockout on mouse embryo development and lipid synthesis.
Title: Effects of CRISPR/Cas9-mediated stearoyl-Coenzyme A desaturase 1 knockout on mouse embryo development and lipid synthesis.
Saprophytic bacteria and fungi colonize stearoyl coenzyme-A desaturase-1 knockout skin.
Title: Saprophytic bacteria and fungi colonize stearoyl coenzyme-A desaturase-1 knockout skin.

Submit: New GeneRIF Correction See all GeneRIFs (140)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (4) 1 citation
Gene trapped (1)
Targeted (4) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M21285 (e-PCR)
- UniSTS:124929

D18Mit29 (e-PCR), detects polymorphism
- UniSTS:128257

UniSTS:498485 (e-PCR)
- UniSTS:498485

Scd1 (e-PCR), detects polymorphism
- UniSTS:498485

RH125028 (e-PCR)
- UniSTS:161850

AI265570 (e-PCR)
- UniSTS:160845

Scd1 (e-PCR), detects polymorphism
- UniSTS:461929

D19Nds1 (e-PCR), detects polymorphism
- UniSTS:142219

Scd1 (e-PCR), detects polymorphism
- UniSTS:547468

D19Mit67 (e-PCR), detects polymorphism
- UniSTS:128407

D19Mit67.2 (e-PCR), detects polymorphism
- UniSTS:128408

Scd1 (e-PCR), detects polymorphism
- UniSTS:498404

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables iron ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IEA Inferred from Electronic Annotation more info
enables palmitoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-CoA 9-desaturase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyl-CoA 9-desaturase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables stearoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IDA Inferred from Direct Assay more info	PubMed
enables stearoyl-CoA 9-desaturase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables stearoyl-CoA 9-desaturase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol homeostasis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in monounsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in monounsaturated fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in sebaceous gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tarsal gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in unsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within white fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-CoA desaturase 1

Names: asebia; delta(9)-desaturase 1; fatty acid desaturase 1; stearoyl-CoA desaturase 1

NP_033153.2

EC 1.14.19.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009127.4 → NP_033153.2 acyl-CoA desaturase 1

See identical proteins and their annotated locations for NP_033153.2

Status: VALIDATED

Source sequence(s)

AA881780, AK012370, AK148103, BQ885468, BU053011, CD544724

Consensus CDS

CCDS29850.1

UniProtKB/Swiss-Prot

P13516, Q922I6

UniProtKB/TrEMBL

Q547C4

Related

ENSMUSP00000036936.3, ENSMUST00000041331.4

Conserved Domains (2) summary

cd03505
Location:93 → 333

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

pfam00487
Location:98 → 301

FA_desaturase; Fatty acid desaturase