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Rtkn rhotekin [ Mus musculus (house mouse) ]

Gene ID: 20166, updated on 5-Mar-2024

Summary

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Official Symbol
Rtknprovided by MGI
Official Full Name
rhotekinprovided by MGI
Primary source
MGI:MGI:107371
See related
Ensembl:ENSMUSG00000034930 AllianceGenome:MGI:107371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol. Predicted to be active in actomyosin contractile ring. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human RTKN (rhotekin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 11.3), duodenum adult (RPKM 8.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 C3; 6 35.94 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83112485..83129560)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83135505..83152579)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E344 Neighboring gene WW domain binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9669 Neighboring gene INO80 complex subunit B Neighboring gene RIKEN cDNA 1700003E16 gene Neighboring gene WD repeat domain 54

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells. Yuasa K, et al. Biochem Biophys Res Commun, 2012 May 4. PMID 22503686
  2. RhoA GTPase regulates B cell receptor signaling. Saci A, et al. Mol Cell, 2005 Jan 21. PMID 15664190
  3. Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145-D2S286. Fu Q, et al. Genomics, 2000 Jun 15. PMID 10873388
  4. Effect of cancer-associated mutations in the PlexinB1 gene. Zhou C, et al. Mol Cancer, 2012 Mar 9. PMID 22404908, Free PMC Article
  5. High blood pressure arising from a defect in vascular function. Michael SK, et al. Proc Natl Acad Sci U S A, 2008 May 6. PMID 18448676, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings suggest that cGK-Ialpha interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation.
    Title: cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in actomyosin contractile ring assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in septin ring organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
rhotekin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136227.2 → NP_001129699.1  rhotekin isoform a

    See identical proteins and their annotated locations for NP_001129699.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes isoform a.
    Source sequence(s)
    AC104324
    Consensus CDS
    CCDS51817.1
    UniProtKB/Swiss-Prot
    E9QM24, Q61192, Q8C6B2, Q8VIG7
    Related
    ENSMUSP00000065571.5, ENSMUST00000065512.11
    Conserved Domains (4) summary
    smart00742
    Location:37 → 91
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam00169
    Location:333 → 411
    PH; PH domain
    pfam08174
    Location:117 → 270
    Anillin; Cell division protein anillin
    cl17171
    Location:309 → 419
    PH-like; Pleckstrin homology-like domain

  2. NM_001355524.2 → NP_001342453.2  rhotekin isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is longer and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC104324

  3. NM_001355525.2 → NP_001342454.2  rhotekin isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, 5' coding region, 3' coding region, and 3' UTR, compared to variant 1. The resulting isoform (d) is shorter and has distinct N- and C-termini, compared to isoform a.
    Source sequence(s)
    AC104324

  4. NM_001410312.1 → NP_001397241.1  rhotekin isoform e

    Status: VALIDATED

    Source sequence(s)
    AC104324

  5. NM_001410313.1 → NP_001397242.1  rhotekin isoform e

    Status: VALIDATED

    Source sequence(s)
    AC104324

  6. NM_001410314.1 → NP_001397243.1  rhotekin isoform f

    Status: VALIDATED

    Source sequence(s)
    AC104324

  7. NM_001410315.1 → NP_001397244.1  rhotekin isoform g

    Status: VALIDATED

    Source sequence(s)
    AC104324

  8. NM_001410316.1 → NP_001397245.1  rhotekin isoform h

    Status: VALIDATED

    Source sequence(s)
    AC104324

  9. NM_009106.3 → NP_033132.2  rhotekin isoform b

    See identical proteins and their annotated locations for NP_033132.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC104324
    Consensus CDS
    CCDS20274.1
    UniProtKB/Swiss-Prot
    Q8C6B2
    Related
    ENSMUSP00000112501.2, ENSMUST00000121093.8
    Conserved Domains (4) summary
    smart00742
    Location:23 → 78
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam00169
    Location:320 → 398
    PH; PH domain
    pfam08174
    Location:104 → 257
    Anillin; Cell division protein anillin
    cl17171
    Location:296 → 406
    PH-like; Pleckstrin homology-like domain

  10. NM_133641.3 → NP_598396.2  rhotekin isoform b

    See identical proteins and their annotated locations for NP_598396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC104324
    Consensus CDS
    CCDS20274.1
    UniProtKB/Swiss-Prot
    Q8C6B2
    Related
    ENSMUSP00000085249.5, ENSMUST00000087938.11
    Conserved Domains (4) summary
    smart00742
    Location:23 → 78
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam00169
    Location:320 → 398
    PH; PH domain
    pfam08174
    Location:104 → 257
    Anillin; Cell division protein anillin
    cl17171
    Location:296 → 406
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83112485..83129560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505810.5 → XP_006505873.1  rhotekin isoform X4

    See identical proteins and their annotated locations for XP_006505873.1

    Conserved Domains (3) summary
    pfam08174
    Location:67 → 220
    Anillin; Cell division protein anillin
    cl00087
    Location:1 → 41
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl17171
    Location:259 → 314
    PH-like; Pleckstrin homology-like domain

  2. XM_006505807.3 → XP_006505870.1  rhotekin isoform X2

    Conserved Domains (3) summary
    smart00742
    Location:37 → 91
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam08174
    Location:117 → 270
    Anillin; Cell division protein anillin
    cl17171
    Location:309 → 364
    PH-like; Pleckstrin homology-like domain

  3. XM_006505808.3 → XP_006505871.1  rhotekin isoform X3

    See identical proteins and their annotated locations for XP_006505871.1

    Conserved Domains (3) summary
    smart00742
    Location:23 → 78
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam08174
    Location:104 → 257
    Anillin; Cell division protein anillin
    cl17171
    Location:296 → 351
    PH-like; Pleckstrin homology-like domain

  4. XM_006505809.3 → XP_006505872.1  rhotekin isoform X3

    See identical proteins and their annotated locations for XP_006505872.1

    Conserved Domains (3) summary
    smart00742
    Location:23 → 78
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam08174
    Location:104 → 257
    Anillin; Cell division protein anillin
    cl17171
    Location:296 → 351
    PH-like; Pleckstrin homology-like domain

  5. XM_006505811.3 → XP_006505874.1  rhotekin isoform X4

    See identical proteins and their annotated locations for XP_006505874.1

    Conserved Domains (3) summary
    pfam08174
    Location:67 → 220
    Anillin; Cell division protein anillin
    cl00087
    Location:1 → 41
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl17171
    Location:259 → 314
    PH-like; Pleckstrin homology-like domain

  6. XM_030255274.2 → XP_030111134.1  rhotekin isoform X7

    Conserved Domains (3) summary
    smart00742
    Location:23 → 78
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam08174
    Location:104 → 257
    Anillin; Cell division protein anillin
    cl17171
    Location:296 → 406
    PH-like; Pleckstrin homology-like domain

  7. XM_006505805.4 → XP_006505868.1  rhotekin isoform X1

    Conserved Domains (3) summary
    smart00742
    Location:82 → 135
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam08174
    Location:161 → 314
    Anillin; Cell division protein anillin
    cl17171
    Location:353 → 408
    PH-like; Pleckstrin homology-like domain

  8. XM_006505812.2 → XP_006505875.1  rhotekin isoform X4

    See identical proteins and their annotated locations for XP_006505875.1

    Conserved Domains (3) summary
    pfam08174
    Location:67 → 220
    Anillin; Cell division protein anillin
    cl00087
    Location:1 → 41
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl17171
    Location:259 → 314
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C6B2.3 GenPept UniProtKB/Swiss-Prot:Q8C6B2

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