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Polr1d polymerase (RNA) I polypeptide D [ Mus musculus (house mouse) ]

Gene ID: 20018, updated on 5-Mar-2024

Summary

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Official Symbol
Polr1dprovided by MGI
Official Full Name
polymerase (RNA) I polypeptide Dprovided by MGI
Primary source
MGI:MGI:108403
See related
Ensembl:ENSMUSG00000029642 AllianceGenome:MGI:108403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AC19; RPA16; Rpo1-3; 1110003G10Rik
Summary
This gene encodes an RNA polymerase subunit that is a component of both the RNA polymerase I and RNA polymerase III complexes. RNA polymerase I is associated with transcription of pre-ribosomal RNAs, while RNA polymerase III is associated with transcription of small RNAs. Pseudogenes of this gene have been defined on chromosomes 4 and 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Expression
Ubiquitous expression in testis adult (RPKM 34.1), placenta adult (RPKM 28.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G3; 5 86.73 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147013525..147048171)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147076715..147111361)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46936 Neighboring gene ligand of numb-protein X 2 Neighboring gene STARR-positive B cell enhancer ABC_E6405 Neighboring gene STARR-positive B cell enhancer ABC_E6406 Neighboring gene STARR-seq mESC enhancer starr_14866 Neighboring gene STARR-positive B cell enhancer ABC_E2184 Neighboring gene STARR-positive B cell enhancer ABC_E8092 Neighboring gene ribosomal protein S10, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_14868 Neighboring gene predicted gene, 34994 Neighboring gene GS homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III. Yao Y, et al. J Biol Chem, 1996 Dec 20. PMID 8955128
  2. Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice. Miao X, et al. Mol Reprod Dev, 2020 Nov. PMID 33022126, Free PMC Article
  3. Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development. Falcon KT, et al. Proc Natl Acad Sci U S A, 2022 Aug 2. PMID 35881792, Free PMC Article
  4. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. Yamamoto K, et al. Mol Cell Biol, 2004 Jul. PMID 15226435, Free PMC Article
  5. RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. Hüttenhofer A, et al. EMBO J, 2001 Jun 1. PMID 11387227, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice.
    Title: Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107156, 1110003G10Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase I complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerases I and III subunit RPAC2
Names
DNA-directed RNA polymerase I 16 kDa polypeptide
RNA polymerase 1-3
RNA polymerases I and III subunit AC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009087.2 → NP_033113.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform 1

    See identical proteins and their annotated locations for NP_033113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AA023617, AK002811, BM948930
    Consensus CDS
    CCDS19876.1
    UniProtKB/Swiss-Prot
    P97304
    UniProtKB/TrEMBL
    Q545W2
    Related
    ENSMUSP00000058355.4, ENSMUST00000050970.4
    Conserved Domains (1) summary
    cd07029
    Location:30 → 114
    RNAP_I_III_AC19; AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III

  2. NM_181730.4 → NP_859419.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform 2

    See identical proteins and their annotated locations for NP_859419.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    BC087884, BF462386, BM948930
    Consensus CDS
    CCDS39397.1
    UniProtKB/TrEMBL
    Q8R1M3, Q99M44, Q9D1M1
    Related
    ENSMUSP00000106186.2, ENSMUST00000110557.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    147013525..147048171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254228.1 → XP_030110088.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

    UniProtKB/TrEMBL
    Q8R1M3, Q99M44, Q9D1M1

  2. XM_030254231.1 → XP_030110091.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

    UniProtKB/TrEMBL
    Q8R1M3, Q99M44, Q9D1M1

  3. XM_036164932.1 → XP_036020825.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

    UniProtKB/TrEMBL
    Q8R1M3, Q99M44, Q9D1M1

  4. XM_030254230.1 → XP_030110090.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

    UniProtKB/TrEMBL
    Q8R1M3, Q99M44, Q9D1M1

  5. XM_030254232.1 → XP_030110092.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

    UniProtKB/TrEMBL
    Q8R1M3, Q99M44, Q9D1M1

  6. XM_030254229.1 → XP_030110089.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

    UniProtKB/TrEMBL
    Q8R1M3, Q99M44, Q9D1M1

  7. XM_030254233.1 → XP_030110093.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97304.1 GenPept UniProtKB/Swiss-Prot:P97304

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