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Rpl10a ribosomal protein L10A [ Mus musculus (house mouse) ]

Gene ID: 19896, updated on 11-Apr-2024

Summary

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Official Symbol
Rpl10aprovided by MGI
Official Full Name
ribosomal protein L10Aprovided by MGI
Primary source
MGI:MGI:1343877
See related
Ensembl:ENSMUSG00000037805 AllianceGenome:MGI:1343877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nedd6; CsA-19
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and maturation of LSU-rRNA. Located in synapse. Is expressed in several structures, including cerebral cortex; heart; immune system; liver; and lung. Orthologous to human RPL10A (ribosomal protein L10a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 583.9), CNS E11.5 (RPKM 479.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 14.65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28547557..28550007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28328471..28331033)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene peroxisome proliferator activator receptor delta Neighboring gene RIKEN cDNA 1810013A23 gene Neighboring gene STARR-positive B cell enhancer ABC_E10941 Neighboring gene STARR-positive B cell enhancer ABC_E2476 Neighboring gene Fanconi anemia, complementation group E Neighboring gene TEA domain family member 3 Neighboring gene STARR-seq mESC enhancer starr_42209 Neighboring gene TUB like protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Development of a new macrophage-specific TRAP mouse (Mac(TRAP)) and definition of the renal macrophage translational signature. Hofmeister A, et al. Sci Rep, 2020 May 5. PMID 32372032, Free PMC Article
  2. Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19. Fisicaro N, et al. Mol Immunol, 1995 Jun. PMID 7609734
  3. Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Kumar S, et al. Biochem Biophys Res Commun, 1992 Jun 30. PMID 1378265
  4. A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production. Genuth NR, et al. Nat Commun, 2022 Sep 19. PMID 36123354, Free PMC Article
  5. Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Kondrashov N, et al. Cell, 2011 Apr 29. PMID 21529712, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production.
    Title: A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation ISO
Inferred from Sequence Orthology
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein uL1
Names
60S ribosomal protein L10a
NEDD-6
neural precursor cell expressed developmentally down-regulated protein 6
NP_001344557.1
NP_035417.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357628.2 → NP_001344557.1  large ribosomal subunit protein uL1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT025652
    UniProtKB/TrEMBL
    Q99JL6
    Related
    ENSMUST00000150103.3
    Conserved Domains (1) summary
    cl00322
    Location:23 → 133
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

  2. NM_011287.3 → NP_035417.2  large ribosomal subunit protein uL1 isoform 1

    See identical proteins and their annotated locations for NP_035417.2

    Status: VALIDATED

    Source sequence(s)
    CT025652
    Consensus CDS
    CCDS28576.1
    UniProtKB/Swiss-Prot
    P53026
    UniProtKB/TrEMBL
    Q3U561, Q5XJF6
    Related
    ENSMUSP00000048469.9, ENSMUST00000042334.16
    Conserved Domains (1) summary
    cl00322
    Location:2 → 217
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28547557..28550007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53026.3 GenPept UniProtKB/Swiss-Prot:P53026

Gene LinkOut

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