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Rel reticuloendotheliosis oncogene [ Mus musculus (house mouse) ]

Gene ID: 19696, updated on 21-Apr-2024

Summary

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Official Symbol
Relprovided by MGI
Official Full Name
reticuloendotheliosis oncogeneprovided by MGI
Primary source
MGI:MGI:97897
See related
Ensembl:ENSMUSG00000020275 AllianceGenome:MGI:97897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
c-Rel
Summary
Enables DNA-binding transcription factor activity. Acts upstream of or within positive regulation of interleukin-12 production and positive regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in eye; genitourinary system; and heart. Orthologous to human REL (REL proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 6.1), thymus adult (RPKM 3.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A3.2; 11 14.36 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23686847..23720969, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23736847..23770969, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SANT and BTB domain regulator of CSR Neighboring gene peroxisomal biogenesis factor 13 Neighboring gene pseudouridylate synthase 10 Neighboring gene STARR-seq mESC enhancer starr_28923 Neighboring gene STARR-seq mESC enhancer starr_28924 Neighboring gene predicted gene, 39612 Neighboring gene STARR-seq mESC enhancer starr_28925 Neighboring gene poly(A) polymerase gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:23795118-23795419 Neighboring gene predicted gene 12061

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The NF-κB Transcription Factor c-Rel Modulates Group 2 Innate Lymphoid Cell Effector Functions and Drives Allergic Airway Inflammation. Mindt BC, et al. Front Immunol, 2021. PMID 34867937, Free PMC Article
  2. The c-Rel transcription factor limits early interferon and neuroinflammatory responses to prevent herpes simplex encephalitis onset in mice. Mancini M, et al. Sci Rep, 2021 Oct 27. PMID 34707143, Free PMC Article
  3. c-Rel employs multiple mechanisms to promote the thymic development and peripheral function of regulatory T cells in mice. Fulford TS, et al. Eur J Immunol, 2021 Aug. PMID 33960413
  4. Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging. Leslie J, et al. Sci Rep, 2021 Jan 14. PMID 33446811, Free PMC Article
  5. cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis. Worrell JC, et al. Rheumatology (Oxford), 2020 Dec 1. PMID 32725139

See all (256) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NF-kappaB subunits RelA and c-Rel selectively control CD4+ T cell function in multiple sclerosis and cancer.
    Title: NF-κB subunits RelA and c-Rel selectively control CD4+ T cell function in multiple sclerosis and cancer.
  2. Co-imaging of RelA and c-Rel reveals features of NF-kappaB signaling for ligand discrimination.
    Title: Co-imaging of RelA and c-Rel reveals features of NF-κB signaling for ligand discrimination.
  3. c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis.
    Title: c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis.
  4. The c-Rel transcription factor limits early interferon and neuroinflammatory responses to prevent herpes simplex encephalitis onset in mice.
    Title: The c-Rel transcription factor limits early interferon and neuroinflammatory responses to prevent herpes simplex encephalitis onset in mice.
  5. The NF-kappaB Transcription Factor c-Rel Modulates Group 2 Innate Lymphoid Cell Effector Functions and Drives Allergic Airway Inflammation.
    Title: The NF-κB Transcription Factor c-Rel Modulates Group 2 Innate Lymphoid Cell Effector Functions and Drives Allergic Airway Inflammation.
  6. Integrative analysis suggests cell type-specific decoding of NF-kappaB dynamics.
    Title: Integrative analysis suggests cell type-specific decoding of NF-κB dynamics.
  7. c-Rel employs multiple mechanisms to promote the thymic development and peripheral function of regulatory T cells in mice.
    Title: c-Rel employs multiple mechanisms to promote the thymic development and peripheral function of regulatory T cells in mice.
  8. NF-kappaB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells.
    Title: NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells.
  9. Extracellular Release of Antigen by Dendritic Cell Regurgitation Promotes B Cell Activation through NF-kappaB/cRel.
    Title: Extracellular Release of Antigen by Dendritic Cell Regurgitation Promotes B Cell Activation through NF-κB/cRel.
  10. c-Rel gain in B cells drives germinal center reactions and autoantibody production.
    Title: c-Rel gain in B cells drives germinal center reactions and autoantibody production.
Submit: New GeneRIF Correction See all GeneRIFs (86)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in non-canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proto-oncogene c-Rel
Names
C-Rel proto-oncogene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009044.3 → NP_033070.2  proto-oncogene c-Rel

    See identical proteins and their annotated locations for NP_033070.2

    Status: VALIDATED

    Source sequence(s)
    AL805916
    Consensus CDS
    CCDS24480.1
    UniProtKB/Swiss-Prot
    P15307
    UniProtKB/TrEMBL
    A4QPD3
    Related
    ENSMUSP00000099928.4, ENSMUST00000102864.5
    Conserved Domains (2) summary
    cd07933
    Location:8 → 179
    RHD-n_c-Rel; N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel
    pfam16179
    Location:187 → 282
    RHD_dimer; Rel homology dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    23686847..23720969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15307.2 GenPept UniProtKB/Swiss-Prot:P15307

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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