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Rbmy RNA binding motif protein, Y chromosome [ Mus musculus (house mouse) ]

Gene ID: 19657, updated on 8-Feb-2024

Summary

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Official Symbol
Rbmyprovided by MGI
Official Full Name
RNA binding motif protein, Y chromosomeprovided by MGI
Primary source
MGI:MGI:104732
See related
Ensembl:ENSMUSG00000094658 AllianceGenome:MGI:104732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RBM; Rbm1; Rbmy1b; Rbmy1a1; Rbm1-rs1; Rbmy1a1-rs1
Summary
Predicted to enable identical protein binding activity and mRNA binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in nucleus. Is expressed in central nervous system; sensory organ; and testis. Orthologous to several human genes including RBMY1B (RNA binding motif protein Y-linked family 1 member B); RBMY1D (RNA binding motif protein Y-linked family 1 member D); and RBMY1E (RNA binding motif protein Y-linked family 1 member E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 1.6) See more
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Genomic context

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Location:
Y; Ypter
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (2830680..2841858)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (2830680..2841858)

Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene ras homolog gene family, member A pseudogene Neighboring gene predicted gene 8498 Neighboring gene predicted gene 8502 Neighboring gene RNA binding motif protein Y-linked family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability. Pertile MD, et al. Genome Res, 2009 Dec. PMID 19737860, Free PMC Article
  2. The role of human and mouse Y chromosome genes in male infertility. Affara NA, et al. J Endocrinol Invest, 2000 Nov. PMID 11097427
  3. Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}. Dreumont N, et al. J Cell Sci, 2010 Jan 1. PMID 20016065
  4. Identification of target messenger RNA substrates for mouse RBMY. Zeng M, et al. Mol Hum Reprod, 2008 Jun. PMID 18492746
  5. An RBM homologue maps to the mouse Y chromosome and is expressed in germ cells. Elliott DJ, et al. Hum Mol Genet, 1996 Jul. PMID 8817321

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. regulates germline-specific splicing events
    Title: Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}.
  2. mRBMY protein may have high affinity to oligo(A) rich sequences; mRBMY protein can bind to the testis and sperm-specific spa17 mRNA
    Title: Identification of target messenger RNA substrates for mouse RBMY.
  3. RNA transport element RTE evolved as a high affinity RBM15 ligand to provide a splicing-independent link to NXF1, thereby ensuring efficient nuclear export and expression of retrotransposon transcripts
    Title: RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding motif protein, Y chromosome, family 1 member A1
Names
RNA binding motif protein, Y chromosome, family 1, member A1, related sequence 1
RNA-binding motif protein 1
RNA-binding motif protein, Y chromosome, family 1 member B
y chromosome RNA recognition motif 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166384.1 → NP_001159856.1  RNA-binding motif protein, Y chromosome, family 1 member A1

    See identical proteins and their annotated locations for NP_001159856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC132601, AK016258
    Consensus CDS
    CCDS30546.1
    UniProtKB/Swiss-Prot
    E9Q856, O35698
    Related
    ENSMUSP00000130080.2, ENSMUST00000171534.8
    Conserved Domains (2) summary
    COG0724
    Location:9 → 85
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:7 → 86
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_011253.2 → NP_035383.2  RNA-binding motif protein, Y chromosome, family 1 member A1

    See identical proteins and their annotated locations for NP_035383.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC132601, AK016258
    Consensus CDS
    CCDS30546.1
    UniProtKB/Swiss-Prot
    E9Q856, O35698
    Related
    ENSMUSP00000097930.4, ENSMUST00000100360.5
    Conserved Domains (2) summary
    COG0724
    Location:9 → 85
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:7 → 86
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000087.8 Reference GRCm39 C57BL/6J

    Range
    2830680..2841858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35698.2 GenPept UniProtKB/Swiss-Prot:O35698

Gene LinkOut

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