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naca nascent polypeptide associated complex subunit alpha [ Danio rerio (zebrafish) ]

Gene ID: 195823, updated on 27-Mar-2024

Summary

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Official Symbol
nacaprovided by ZNC
Official Full Name
nascent polypeptide associated complex subunit alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020423-4
See related
Ensembl:ENSDARG00000005513 AllianceGenome:ZFIN:ZDB-GENE-020423-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
nkn; tdsubc_2b5; unm_t30953; ik:tdsubc_2b5; xx:tdsubc_2b5
Summary
Predicted to enable unfolded protein binding activity. Acts upstream of or within definitive hemopoiesis and myofibril assembly. Located in cytoplasm and nucleus. Is expressed in cardiac muscle; hematopoietic system; skeletal muscle; and somite. Orthologous to several human genes including NACA (nascent polypeptide associated complex subunit alpha) and NACA2 (nascent polypeptide associated complex subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (17866008..17874341)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (17939665..17947998)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene Rho family GTPase 1a Neighboring gene DNA primase subunit 1 Neighboring gene tuftelin interacting protein 11 Neighboring gene calcium-independent phospholipase A2-gamma-like Neighboring gene neurofascin homolog (chicken) b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization. Li H, et al. FASEB J, 2009 Jun. PMID 19211926
  2. NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation. Murayama E, et al. Nat Commun, 2015 Sep 28. PMID 26411530
  3. RES complex is associated with intron definition and required for zebrafish early embryogenesis. Fernandez JP, et al. PLoS Genet, 2018 Jul. PMID 29969449, Free PMC Article
  4. The important role of apolipoprotein A-II in ezetimibe driven reduction of high cholesterol diet-induced atherosclerosis. Yan Y, et al. Atherosclerosis, 2019 Jan. PMID 30500605
  5. Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo. Lemeer S, et al. J Proteome Res, 2008 Apr. PMID 18307296

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results demonstrate that skNAC plays a vital role in myofibril assembly and function during muscle cell differentiation.
    Title: skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myofibril assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nascent polypeptide-associated complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nascent polypeptide-associated complex subunit alpha
Names
NAC-alpha
alpha-NAC
nascent polypeptide-associated complex alpha polypeptide
nascent polypeptide-associated complex alpha subunit
no knack
sknac
unm t30953
NP_001180281.1
NP_775371.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193352.1 → NP_001180281.1  nascent polypeptide-associated complex subunit alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), also known as the skeletal naca (sknac) isoform.
    Source sequence(s)
    AY398384, CR381647
    UniProtKB/TrEMBL
    A0A0R4IQN8
    Related
    ENSDARP00000136310.1, ENSDART00000162822.2
    Conserved Domains (3) summary
    COG1308
    Location:889 → 1030
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    cd14415
    Location:984 → 1029
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    pfam01849
    Location:890 → 943
    NAC; NAC domain

  2. NM_173264.2 → NP_775371.1  nascent polypeptide-associated complex subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_775371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AY398384, CR381647
    UniProtKB/Swiss-Prot
    Q0P3U9, Q8JIU7
    UniProtKB/TrEMBL
    B2GPE2
    Related
    ENSDARP00000025953.5, ENSDART00000014723.7
    Conserved Domains (3) summary
    COG1308
    Location:74 → 215
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    cd14415
    Location:169 → 214
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    pfam01849
    Location:75 → 128
    NAC; NAC domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    17866008..17874341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JIU7.1 GenPept UniProtKB/Swiss-Prot:Q8JIU7

Gene LinkOut

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