fshr follicle stimulating hormone receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fshrprovided by ZNC
Official Full Name: follicle stimulating hormone receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020423-5
See related: Ensembl:ENSDARG00000071494 AllianceGenome:ZFIN:ZDB-GENE-020423-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: GTHR-I; zfGTHR-I
Summary: Enables follicle-stimulating hormone receptor activity. Acts upstream of or within male gonad development; ovarian follicle development; and spermatogenesis. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in Leydig cell; female organism; gonad; and kidney. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Orthologous to human FSHR (follicle stimulating hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (24738966..24770184)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (24617747..24648965)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that double mutation of follicle-stimulating hormone receptor (fshr) and luteinizing hormone receptor (lhcgr) resulted in infertile males.
Title: Disruption of Zebrafish Follicle-Stimulating Hormone Receptor (fshr) But Not Luteinizing Hormone Receptor (lhcgr) Gene by TALEN Leads to Failed Follicle Activation in Females Followed by Sexual Reversal to Males.
Data show for the first time in a vertebrate species that Leydig cells as well as Sertoli cells express the mRNAs for both fshr and lhcgr.
Title: Studies in zebrafish reveal unusual cellular expression patterns of gonadotropin receptor messenger ribonucleic acids in the testis and unexpected functional differentiation of the gonadotropins.
Characterization of the first functional zebrafish (Danio rerio) gonadotropic hormone I receptor (follicle stimulating hormone receptor).
Title: Zebrafish as a model for vertebrate reproduction: characterization of the first functional zebrafish (Danio rerio) gonadotropin receptor.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables follicle-stimulating hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables follicle-stimulating hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables thyroid-stimulating hormone receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within female gonad development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle-stimulating hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: follicle-stimulating hormone receptor

Names: gonadotropic hormone I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001812.1 → NP_001001812.1 follicle-stimulating hormone receptor precursor

See identical proteins and their annotated locations for NP_001001812.1

Status: PROVISIONAL

Source sequence(s)

AY424301

UniProtKB/TrEMBL

Q6TCF9

Related

ENSDARP00000096529.4, ENSDART00000105751.5

Conserved Domains (3) summary

sd00033
Location:79 → 103

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:360 → 607

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13306
Location:93 → 224

LRR_5; Leucine rich repeats (6 copies)