Rab11b RAB11B, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab11bprovided by MGI
Official Full Name: RAB11B, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:99425
See related: Ensembl:ENSMUSG00000077450 AllianceGenome:MGI:99425
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A730055L17Rik
Summary: Enables GTP binding activity and GTPase activity. Involved in several processes, including melanosome transport; protein transport; and regulation of endocytic recycling. Located in recycling endosome membrane. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; limb; and liver. Orthologous to human RAB11B (RAB11B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 49.8), adrenal adult (RPKM 49.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (33961458..33979460, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (33742484..33760486, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells.
Title: RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells.
The Inhibitory Role of Rab11b in Osteoclastogenesis through Triggering Lysosome-Induced Degradation of c-Fms and RANK Surface Receptors.
Title: The Inhibitory Role of Rab11b in Osteoclastogenesis through Triggering Lysosome-Induced Degradation of c-Fms and RANK Surface Receptors.
these data show an interaction between the smallGTPase Rab11b and the BK channel, which suggests that BK is shuttledthrough a slow recycling endocytic pathway.
Title: The large conductance calcium-activated K(+) channel interacts with the small GTPase Rab11b.
These data indicate that Rab11b, and to a lesser extent Rab11a, is involved in establishing the constitutive and cAMP-stimulated Na(+) transport in mpkCCD cells.
Title: Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC).
These findings reveal a novel role for Rab11b in limiting, rather than promoting, the plasma membrane expression of Cav1.2 L-type Ca2+ channels.
Title: Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels.
Study shows that both Rab11 and its effector Rip11 participate in insulin granule exocytosis and that Rip11, as a substrate of PKA, regulates the potentiation of exocytosis by cAMP in pancreatic beta-cells.
Title: Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis.
Data show that in huntingtin-null embryonic stem cells, the levels of Rab11 on membranes and nucleotide exchange activity on Rab11 are significantly reduced compared with normal embryonic stem cells.
Title: A function of huntingtin in guanine nucleotide exchange on Rab11.
These data indicate that Rab11b is necessary for the trafficking of cGK-II and that the cGMP/cGK-II signaling pathway is closely related to Rab11b recycling pathway.
Title: Trafficking of cGMP-dependent protein kinase II via interaction with Rab11.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A730055L17Rik (e-PCR), detects polymorphism
- UniSTS:463397

Rab11b (e-PCR), detects polymorphism
- UniSTS:463424

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance by transcytosis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in constitutive secretory pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in constitutive secretory pathway	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
NOT involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulated exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in transferrin transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-11B

Names: RAS oncogene family protein

NP_033023.1

EC 3.6.5.2

XP_006523950.1

EC 3.6.5.2

XP_030105459.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008997.3 → NP_033023.1 ras-related protein Rab-11B

See identical proteins and their annotated locations for NP_033023.1

Status: VALIDATED

Source sequence(s)

AK036482, AK043096, AK146623, BM935109, BU705914, BY275360

Consensus CDS

CCDS28628.1

UniProtKB/Swiss-Prot

P46638

UniProtKB/TrEMBL

G3UZD3, Q78ZJ8

Related

ENSMUSP00000110021.5, ENSMUST00000057373.14

Conserved Domains (2) summary

PLN03110
Location:5 → 217

PLN03110; Rab GTPase; Provisional

cd01868
Location:9 → 173

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

33961458..33979460 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249599.2 → XP_030105459.1 ras-related protein Rab-11B isoform X1

Conserved Domains (1) summary

cd01868
Location:74 → 233

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
XM_006523887.5 → XP_006523950.1 ras-related protein Rab-11B isoform X2

See identical proteins and their annotated locations for XP_006523950.1

UniProtKB/TrEMBL

G3UZD3

Related

ENSMUSP00000134448.2, ENSMUST00000173860.8

Conserved Domains (1) summary

cd01868
Location:2 → 160

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25