Ptprs protein tyrosine phosphatase receptor type S [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptprsprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Sprovided by MGI
Primary source: MGI:MGI:97815
See related: Ensembl:ENSMUSG00000013236 AllianceGenome:MGI:97815
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PTP; Ptpt9; PTP-NU3; PTPNU-3; R-PTP-S; PTPsigma; RPTPsigma
Summary: Enables chondroitin sulfate binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and regulation of postsynaptic density assembly. Acts upstream of or within central nervous system development and establishment of endothelial intestinal barrier. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and plasma membrane. Is integral component of presynaptic membrane. Is expressed in several structures, including adipose tissue; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human PTPRS (protein tyrosine phosphatase receptor type S). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in whole brain E14.5 (RPKM 169.2), CNS E14 (RPKM 151.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.32 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56719426..56783480, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56412426..56476561, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intact synapse structure and function after combined knockout of PTPdelta, PTPsigma, and LAR.
Title: Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Proteoglycans regulate protein tyrosine phosphatase receptor sigma organization on hematopoietic stem/progenitor cells.
Title: Proteoglycans regulate protein tyrosine phosphatase receptor σ organization on hematopoietic stem/progenitor cells.
Presynaptic PTPsigma regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms.
Title: Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms.
LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.
Title: LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.
Through the heparan sulfate of Nrxn1, LRRTMs recruit PTPsigma to induce presynaptic differentiation but function to varying degrees in its absence. PTPsigma forms a robust complex with Nrxn1, revealing an unexpected interaction between the two presynaptic hubs.
Title: LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ.
We show that PTP-3, a LAR homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR class PTPs, is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues.
Title: Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.
This study provides evidence that chondroitin sulfate (CS) glycosaminoglycans (GAGs) rich in 4,6-O-disulfated disaccharide units known to impede axonal growth can induce RPTPsigma clustering.
Title: Identification of novel binding sites for heparin in receptor protein-tyrosine phosphatase (RPTPσ): Implications for proteoglycan signaling.
Downstream molecular target of protein tyrosine phosphatase sigma (PTPsigma) modulation in oligodendrocyte progenitor cells (OPCs) involving upregulation of the protease matrix metallopeptidase 2 (MMP-2) that allows OPCs to enzymatically digest their way through chondroitin sulfate proteoglycans (CSPGs).
Title: Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis.
These results demonstrate that NME2 associates with PTPsigma to elicit neurite outgrowth inhibition in response to chondroitin sulfate proteoglycans.
Title: NME2 associates with PTPσ to transduce signals from chondroitin sulfate proteoglycans.
Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis
Title: Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125313 (e-PCR)
- UniSTS:162135

NoName (e-PCR)
- UniSTS:237673

Ptprs (e-PCR), detects polymorphism
- UniSTS:536492

BMS1116 (e-PCR), detects polymorphism
- UniSTS:44540

D28530 (e-PCR)
- UniSTS:186111

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chondroitin sulfate binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebellum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within corpus callosum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of endothelial intestinal barrier	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor 9 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic membrane adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase S

Names: R-PTP-sigma; Receptor-type tyrosine-protein phosphatase sigma; tissue-specific protein tyrosine phosphatase

NP_001239382.1

EC 3.1.3.48

NP_001239384.1

EC 3.1.3.48

NP_001239385.1

EC 3.1.3.48

NP_035348.2

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252453.1 → NP_001239382.1 receptor-type tyrosine-protein phosphatase S isoform 2 precursor

See identical proteins and their annotated locations for NP_001239382.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks four consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which is shorter than isoform 1.

Source sequence(s)

BC052462, CT009637

Consensus CDS

CCDS57103.1

UniProtKB/Swiss-Prot

B0V2N1

Conserved Domains (6) summary

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd14625
Location:923 → 1204

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1206 → 1495

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain
NM_001252455.1 → NP_001239384.1 receptor-type tyrosine-protein phosphatase S isoform 3 precursor

See identical proteins and their annotated locations for NP_001239384.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks 5 exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AI845699, BC083188, CT009637

Consensus CDS

CCDS89125.1

UniProtKB/Swiss-Prot

B0V2N1

Related

ENSMUSP00000153134.2, ENSMUST00000223859.2

Conserved Domains (6) summary

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1228 → 1487

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:967 → 1196

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
NM_001252456.1 → NP_001239385.1 receptor-type tyrosine-protein phosphatase S isoform 2 precursor

See identical proteins and their annotated locations for NP_001239385.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks four consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which is shorter than isoform 1.

Source sequence(s)

CT009637

Consensus CDS

CCDS57103.1

UniProtKB/Swiss-Prot

B0V2N1

Related

ENSMUSP00000084038.4, ENSMUST00000086828.10

Conserved Domains (6) summary

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd14625
Location:923 → 1204

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1206 → 1495

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain
NM_011218.2 → NP_035348.2 receptor-type tyrosine-protein phosphatase S isoform 1 precursor

See identical proteins and their annotated locations for NP_035348.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AI845699, AK163915, BC083188, CJ177868, D28530

Consensus CDS

CCDS37664.1

UniProtKB/Swiss-Prot

B0V2N1, Q3TEC3, Q3TXC9, Q4JFC7, Q5XJV4, Q64503, Q64699, Q7TT17

Related

ENSMUSP00000064048.6, ENSMUST00000067538.6

Conserved Domains (6) summary

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd14625
Location:1329 → 1610

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1612 → 1901

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain