Mtnr1b melatonin receptor 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtnr1bprovided by RGD
Official Full Name: melatonin receptor 1Bprovided by RGD
Primary source: RGD:620798
See related: Ensembl:ENSRNOG00000008972 AllianceGenome:RGD:620798
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mt2; Mel1b-r
Summary: Predicted to enable G protein-coupled receptor activity. Involved in several processes, including negative regulation of cGMP-mediated signaling; negative regulation of transport; and regulation of transmission of nerve impulse. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Used to study acute pancreatitis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (melatonin receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 8q12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (20919593..20934109, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (12638219..12652737, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (14359270..14373894, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TBI in rats resulted in lower levels of MT1 and MT2; replication of these findings is necessary as is evaluation of the consequences of lower receptor levels.
Title: Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2.
An inhibitory effect of melatonin on oxytocin secretion from the rat hypothalamo-neurohypophysial system is mediated through a subtype MT1 membrane receptor and its action is independent of subtype MT2 receptor. However, for the stimulatory effect of pharmacological concentration of the pineal hormone on oxytocin release, probably mechanisms other than membrane MT1/MT2 receptor(s)-dependent are involved.
Title: The role of melatonin membrane receptors in melatonin-dependent oxytocin secretion from the rat hypothalamo-neurohypophysial system - an in vitro and in vivo approach.
Suggest MT2 melatonin receptor may be a novel target for analgesic drug development.
Title: Antinociceptive properties of selective MT(2) melatonin receptor partial agonists.
We demonstrated the co-existence of MT1 and MT2 receptors in all melanopsin-positive M1 ipRGCs, and the expression of MT1 and MT2 receptors in these cells could be seen as early as the day of birth (P0).
Title: Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells.
melatonin MT receptor was expressed in somata, dendrites and axon terminals of rat rod-dominant ON type bipolar cells
Title: Melatonin inhibits tetraethylammonium-sensitive potassium channels of rod ON type bipolar cells via MT2 receptors in rat retina.
The present study demonstrates, for the first time, that MT1b receptors are localized and expressed in rat vestibular nuclei. This study provides additional insight into the role of melatonin receptors during vestibular signal processing.
Title: Immunohistochemical and biomolecular identification of melatonin 1a and 1b receptors in rat vestibular nuclei.
MT2 is highly expressed in the hypothalamus, lung, kidney, adrenal gland, stomach, and ovary, while MT2 is highly expressed in the hippocampus, kidney, and ovary
Title: Gene structures, biochemical characterization and distribution of rat melatonin receptors.
These data suggest that the circulating hormone melatonin, which is predominantly released from the pineal gland in the brain, is involved in the pathogenesis of type 2 diabetes.
Title: Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
The rat melatonin receptor 1B (melatonin MT2 receptor)was cloned and the binding affinity for different compounds was compared with the human counterpart.
Title: Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors.
Regulation of MT2 melatonin receptors (Mel1B)by physiological concentrations of melatonin mimicking the nocturnal surge.
Title: Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables melatonin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in camera-type eye development	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cGMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transmission of nerve impulse	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melatonin receptor type 1B

Names: mel-1B-R; mel1b melatonin receptor; mel1b receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393841.1 → NP_001380770.1 melatonin receptor type 1B precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

B7X946, P49287

Related

ENSRNOP00000011883.4, ENSRNOT00000011883.5

Conserved Domains (2) summary

cd14964
Location:42 → 68

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:41 → 319

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily