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pole2 polymerase (DNA directed), epsilon 2 [ Danio rerio (zebrafish) ]

Gene ID: 192320, updated on 27-Mar-2024

Summary

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Official Symbol
pole2provided by ZNC
Official Full Name
polymerase (DNA directed), epsilon 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-020419-16
See related
AllianceGenome:ZFIN:ZDB-GENE-020419-16
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CHUNP6886; wu:fb49c03; wu:fc49h08
Summary
Predicted to enable DNA binding activity. Predicted to be involved in DNA-dependent DNA replication and error-prone translesion synthesis. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleus. Predicted to be part of epsilon DNA polymerase complex. Is expressed in several structures, including eye; immature eye; intestinal bulb primordium; neural plate; and ventricular zone. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (81101..89361, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (116836..122584, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene general transcription factor IIA, 1-like Neighboring gene protein phosphatase 1, regulatory subunit 21 Neighboring gene stonin 1 Neighboring gene kelch domain containing 1 Neighboring gene uncharacterized LOC101883147

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. Kuil LE, et al. Elife, 2020 May 5. PMID 32367800, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of epsilon DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA polymerase epsilon subunit 2
Names
epsilon 2
NP_775353.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173246.1 → NP_775353.1  DNA polymerase epsilon subunit 2

    See identical proteins and their annotated locations for NP_775353.1

    Status: PROVISIONAL

    Source sequence(s)
    AF506228
    UniProtKB/TrEMBL
    Q8JHG8
    Conserved Domains (3) summary
    pfam04042
    Location:288 → 487
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam04598
    Location:2 → 161
    Gasdermin; Gasdermin family
    pfam12213
    Location:3 → 73
    Dpoe2NT; DNA polymerases epsilon N terminal

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    81101..89361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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