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ccna2 cyclin A2 [ Danio rerio (zebrafish) ]

Gene ID: 192295, updated on 30-Mar-2024

Summary

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Official Symbol
ccna2provided by ZNC
Official Full Name
cyclin A2provided by ZNC
Primary source
ZFIN:ZDB-GENE-020418-1
See related
Ensembl:ENSDARG00000011094 AllianceGenome:ZFIN:ZDB-GENE-020418-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CycA2; cb671; chunp6924; wu:fi36f03
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within retina development in camera-type eye. Predicted to be part of cyclin A2-CDK2 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including nervous system; neural tube; pectoral fin musculature; primordial germ cell; and tail bud. Orthologous to human CCNA2 (cyclin A2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ccna2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (46357824..46374670, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (47357468..47387568, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene BTB domain containing 18 Neighboring gene transmembrane protein 33 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene annexin A5a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mesencephalic origin of the inferior lobe in zebrafish. Bloch S, et al. BMC Biol, 2019 Mar 8. PMID 30849972, Free PMC Article
  2. UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis. Chu J, et al. Mol Biol Cell, 2012 Jan. PMID 22072796, Free PMC Article
  3. Cyclin A2/cyclin-dependent kinase 1-dependent phosphorylation of Top2a is required for S phase entry during retinal development in zebrafish. Jin M, et al. J Genet Genomics, 2021 Jan 20. PMID 33832859
  4. Impaired Sleep, Circadian Rhythms and Neurogenesis in Diet-Induced Premature Aging. Stankiewicz AJ, et al. Int J Mol Sci, 2017 Oct 26. PMID 29072584, Free PMC Article
  5. Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos. Hu Z, et al. PLoS One, 2015. PMID 26225764, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. an essential role for UHRF1 phosphorylation by cyclin-dependent kinase 2/cyclin A2 during early vertebrate development
    Title: UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152949.1 → NP_694481.1  cyclin-A2

    See identical proteins and their annotated locations for NP_694481.1

    Status: PROVISIONAL

    Source sequence(s)
    AF234784
    UniProtKB/TrEMBL
    Q7ZVJ2, Q98TA3
    Related
    ENSDARP00000029094.6, ENSDART00000031498.8
    Conserved Domains (3) summary
    pfam00134
    Location:177 → 303
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:305 → 422
    Cyclin_C; Cyclin, C-terminal domain
    pfam16500
    Location:33 → 157
    Cyclin_N2; N-terminal region of cyclin_N

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    46357824..46374670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480961.1 → XP_021336636.1  cyclin-A2 isoform X1

    UniProtKB/TrEMBL
    F1R0L6, Q6NV43
    Related
    ENSDARP00000156205.1, ENSDART00000188313.1
    Conserved Domains (3) summary
    pfam00134
    Location:177 → 303
    Cyclin_N; Cyclin, N-terminal domain
    pfam16500
    Location:33 → 162
    Cyclin_N2; N-terminal region of cyclin_N
    cl25647
    Location:162 → 419
    Cyclin_N2; N-terminal region of cyclin_N
Nucleotide Protein Strain
Heading Accession and Version

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