Ptgs1 prostaglandin-endoperoxide synthase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptgs1provided by MGI
Official Full Name: prostaglandin-endoperoxide synthase 1provided by MGI
Primary source: MGI:MGI:97797
See related: Ensembl:ENSMUSG00000047250 AllianceGenome:MGI:97797
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: COX1; Cox-1; Cox-3; PHS 1; Pghs1; PGHS-1
Summary: This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 9.1), bladder adult (RPKM 9.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 24.19 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (36106758..36142287)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (36216742..36258593)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc<sup>Min/+</sup> mice.
Title: The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc(Min/+) mice.
Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation.
Title: Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation.
Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback.
Title: Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback.
Dynamics of Cyclooxygenase-1 Positive Microglia/Macrophage in the Retina of Pathological Model Mice as a Biomarker of the Retinal Inflammatory Diseases.
Title: Dynamics of Cyclooxygenase-1 Positive Microglia/Macrophage in the Retina of Pathological Model Mice as a Biomarker of the Retinal Inflammatory Diseases.
Exposure to growth hormone is associated with hepatic up-regulation of cPLA2alpha and COX.
Title: Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX.
PTGS1-modified cells were incubated with synthograft and transplanted into the dorsal space of mice. .. HE staining showed that the PTGS1sh group generated much more bone-like tissue compared with the NC group , and quantitative analysis verified that silencing of PTGS1 greatly promoted bone-like tissue formation in vivo
Title: Inhibition of PTGS1 promotes osteogenic differentiation of adipose-derived stem cells by suppressing NF-kB signaling.
Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice
Title: Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice.
Transgenic mice study revealed that knock-in COX-1 failed to substitute for the loss of COX-2 in COX-1>COX-2 mice during implantation, indicating that COX-1 may be replaced by COX-2, but not vice versa. A panel of prostaglandins detected in uterus and ovary demonstrates that prostaglandin biosynthesis preferentially depends on native COX-1, but not COX-2.
Title: Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy.
Expression of COX-1 and production of thromboxane A2 in platelets of STZ-induced diabetic mice were elevated.
Title: Effects of three-month streptozotocin-induced diabetes in mice on blood platelet reactivity, COX-1 expression and adhesion potential.
Manipulation of COXs 1 & 2 revealed isoform-specific compensatory functions and variable degrees of interchangeability for PG biosynthesis in cells/tissues
Title: Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.

Submit: New GeneRIF Correction See all GeneRIFs (117)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (7)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptgs1 (e-PCR), detects polymorphism
- UniSTS:502669

PMC14708P1 (e-PCR)
- UniSTS:271009

Ptgs1 (e-PCR), detects polymorphism
- UniSTS:256485

M34141 (e-PCR)
- UniSTS:158957

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-endoperoxide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-endoperoxide synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cyclooxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cyclooxygenase pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in maintenance of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostaglandin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prostaglandin G/H synthase 1

Names: PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1

NP_032995.1

EC 1.14.99.1

XP_006497853.1

EC 1.14.99.1

XP_006497854.1

EC 1.14.99.1

XP_006497857.1

EC 1.14.99.1

XP_011237338.1

EC 1.14.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008969.4 → NP_032995.1 prostaglandin G/H synthase 1 precursor

See identical proteins and their annotated locations for NP_032995.1

Status: REVIEWED

Source sequence(s)

AK159907, AW493573

Consensus CDS

CCDS15970.1

UniProtKB/Swiss-Prot

P22437

UniProtKB/TrEMBL

Q3UZ23, Q543T1, Q8CIL6

Related

ENSMUSP00000059977.6, ENSMUST00000062069.6

Conserved Domains (2) summary

cd09816
Location:92 → 578

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

cd00054
Location:35 → 72

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

36106758..36142287

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239036.4 → XP_011237338.1 prostaglandin G/H synthase 1 isoform X1

See identical proteins and their annotated locations for XP_011237338.1

UniProtKB/Swiss-Prot

P22437

UniProtKB/TrEMBL

Q3UZ23, Q543T1, Q8CIL6

Conserved Domains (2) summary

cd09816
Location:92 → 578

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

cd00054
Location:35 → 72

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_006497790.5 → XP_006497853.1 prostaglandin G/H synthase 1 isoform X1

See identical proteins and their annotated locations for XP_006497853.1

UniProtKB/Swiss-Prot

P22437

UniProtKB/TrEMBL

Q3UZ23, Q543T1, Q8CIL6

Conserved Domains (2) summary

cd09816
Location:92 → 578

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

cd00054
Location:35 → 72

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_006497791.5 → XP_006497854.1 prostaglandin G/H synthase 1 isoform X1

See identical proteins and their annotated locations for XP_006497854.1

UniProtKB/Swiss-Prot

P22437

UniProtKB/TrEMBL

Q3UZ23, Q543T1, Q8CIL6

Conserved Domains (2) summary

cd09816
Location:92 → 578

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

cd00054
Location:35 → 72

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_006497794.5 → XP_006497857.1 prostaglandin G/H synthase 1 isoform X2

UniProtKB/TrEMBL

Q3UZ23

Related

ENSMUST00000149930.3

Conserved Domains (2) summary

cd09816
Location:74 → 560

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

cd00054
Location:17 → 54

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...