Opn4 opsin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Opn4provided by RGD
Official Full Name: opsin 4provided by RGD
Primary source: RGD:621701
See related: Ensembl:ENSRNOG00000053893 AllianceGenome:RGD:621701
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G protein-coupled photoreceptor activity. Involved in phototransduction. Predicted to be located in sperm head plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 2.7), Heart (RPKM 2.3) and 5 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 16p15

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (9926638..9935810, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (9920408..9929580, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (10943353..10966602, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

during retinal degeneration, the expression of melanopsin was significantly decreased, while vector-mediated overexpression of melanopsin delayed the loss of visual function in rats.
Title: Overexpression of melanopsin in the retina restores visual function in Royal College of Surgeons rats.
Following ON injury or retrograde tracing there is a transient melanopsin downregulation that should be taken into account when assessing m(+)RGC survival.
Title: Transient Downregulation of Melanopsin Expression After Retrograde Tracing or Optic Nerve Injury in Adult Rats.
Data indicate that the phosphorylation status of melanopsin influences its functions.
Title: Phosphorylation of rat melanopsin at Ser-381 and Ser-398 by light/dark and its importance for intrinsically photosensitive ganglion cells (ipRGCs) cellular Ca2+ signaling.
Early light exposure can increase the number of melanopsin immunopositive retinal ganalion cells through a process dependent on intrinsic photosensitive spiking activity.
Title: Controlling the number of melanopsin-containing retinal ganglion cells by early light exposure.
We found that light and darkness are important for regulation of melanopsin protein expression whereas input from a retinal networks regulates melanopsin mRNA expression.
Title: Differential expression of melanopsin mRNA and protein in Brown Norwegian rats.
overexpression of mir133b decreased TH and D2 receptor expression as well as dopamine production, which finally resulted in reduced melanopsin expression
Title: A microRNA, mir133b, suppresses melanopsin expression mediated by failure dopaminergic amacrine cells in RCS rats.
The presence and co-localization of vesicular glutamate transporter 2 and PACAP in retinal ganglion cell and their projections in the brain, is described.
Title: Vesicular glutamate transporter 2 (VGLUT2) is co-stored with PACAP in projections from the rat melanopsin-containing retinal ganglion cells.
The PI3 K/Akt pathway was found to play a role in maintaining the survival of melanopsin-expressing retinal ganglion cells after injury.
Title: Enhanced survival of melanopsin-expressing retinal ganglion cells after injury is associated with the PI3 K/Akt pathway.
the daily and photoperiod-dependent regulation of the melanopsin gene does not rely on a circadian oscillator but is directly illumination-dependent
Title: Daily profile in melanopsin transcripts depends on seasonal lighting conditions in the rat retina.
melanopsin-containing RGCs have synaptic contact with PKC/CtBP2-containing rod bipolar cells
Title: Synaptic contact between melanopsin-containing retinal ganglion cells and rod bipolar cells.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 11-cis retinal binding	ISO Inferred from Sequence Orthology more info
enables 11-cis retinal binding	ISS Inferred from Sequence or Structural Similarity more info
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled photoreceptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled photoreceptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of temperature stimulus involved in thermoception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within entrainment of circadian clock by photoperiod	ISO Inferred from Sequence Orthology more info
involved_in hyaloid vascular plexus regression	ISO Inferred from Sequence Orthology more info
involved_in hyaloid vascular plexus regression	ISS Inferred from Sequence or Structural Similarity more info
involved_in optokinetic behavior	ISO Inferred from Sequence Orthology more info
involved_in optokinetic behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phototransduction	IDA Inferred from Direct Assay more info	PubMed
involved_in phototransduction	IEA Inferred from Electronic Annotation more info
involved_in phototransduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of circadian sleep/wake cycle, sleep	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within response to light stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhodopsin mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thermotaxis	ISO Inferred from Sequence Orthology more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm head plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: melanopsin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138860.1 → NP_620215.1 melanopsin

See identical proteins and their annotated locations for NP_620215.1

Status: PROVISIONAL

Source sequence(s)

AY072689

UniProtKB/Swiss-Prot

Q8R456

UniProtKB/TrEMBL

A0A8I5ZNW1, A6KFQ9

Related

ENSRNOP00000069548.1, ENSRNOT00000091315.2

Conserved Domains (2) summary

cd14964
Location:72 → 98

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:71 → 358

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily