Ptger1 prostaglandin E receptor 1 (subtype EP1) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptger1provided by MGI
Official Full Name: prostaglandin E receptor 1 (subtype EP1)provided by MGI
Primary source: MGI:MGI:97793
See related: Ensembl:ENSMUSG00000019464 AllianceGenome:MGI:97793
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EP1; Ptgerep1
Summary: Enables D1 dopamine receptor binding activity. Involved in adenylate cyclase-activating dopamine receptor signaling pathway. Acts upstream of or within response to lipopolysaccharide. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and immune system. Orthologous to human PTGER1 (prostaglandin E receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 44.9), spleen adult (RPKM 41.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2; 8 40.22 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (84393171..84399385)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (83666644..83672756)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2.
Title: EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2.
Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair.
Title: Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair.
regulates renal aquaporins and sodium transporters, attenuates AVP-water transport and inhibits sodium transport in the mouse collecting duct
Title: PGE(2) EP(1) receptor inhibits vasopressin-dependent water reabsorption and sodium transport in mouse collecting duct.
Loss of EP1 results in inactivation of Hif1alpha, increased oxygen consumption rate and thus increased osteoblast differentiation.
Title: PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism.
PGE2 serves as a central regulator of the Ren-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB pathway.
Title: PGE(2) upregulates renin through E-prostanoid receptor 1 via PKC/cAMP/CREB pathway in M-1 cells.
Our study identifies the EP1 signaling pathway as an important link between neuroinflammation and MMP-mediated BBB breakdown in ischemic stroke.
Title: Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.
EP1-/- mice maintain increased bone mineral density and stronger cortical and trabecular bone biomechanical properties with aging. The EP1 receptor acts to inhibit bone marrow osteoprogenitor cell differentiation and mineralization.
Title: Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength.
Results indicate that EP1 receptor activation during seizures, through a protein kinase C pathway, increases probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response
Title: The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus.
The EP1 receptor facilitates the actions of angiotensin II, thereby suggesting that targeting of both the renin-angiotensin system and the EP1 receptor could be beneficial in diabetic nephropathy.
Title: PTGER1 deletion attenuates renal injury in diabetic mouse models.
Propose a mechanism whereby ANG II increases COX-1-derived PGE2 through the AT1R/PLA2 pathway, which promotes ROS production by EP1R/Nox2 signaling in the subfornical organ.
Title: COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca(2+) influx in the subfornical organ.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptger1 (e-PCR), detects polymorphism
- UniSTS:495971

PMC209534P1 (e-PCR)
- UniSTS:272001

Ptger1 (e-PCR), detects polymorphism
- UniSTS:144290

M-07712 (e-PCR)
- UniSTS:186282

PMC327192P3 (e-PCR)
- UniSTS:273137

PMC199184P1 (e-PCR)
- UniSTS:271859

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin E receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin E receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prostaglandin E2 receptor EP1 subtype

Names: PGE receptor EP1 subtype; PGE2 receptor EP1 subtype; prostanoid EP1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013641.3 → NP_038669.1 prostaglandin E2 receptor EP1 subtype

See identical proteins and their annotated locations for NP_038669.1

Status: VALIDATED

Source sequence(s)

AC164432, AK053616, AK164746

Consensus CDS

CCDS22458.1

UniProtKB/Swiss-Prot

P35375

UniProtKB/TrEMBL

B2RS62

Related

ENSMUSP00000019608.6, ENSMUST00000019608.7

Conserved Domains (1) summary

pfam00001
Location:302 → 354

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

84393171..84399385

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530771.5 → XP_006530834.1 prostaglandin E2 receptor EP1 subtype isoform X1

Conserved Domains (2) summary

cd14964
Location:70 → 96

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:69 → 394

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily