Ptgdr prostaglandin D receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptgdrprovided by MGI
Official Full Name: prostaglandin D receptorprovided by MGI
Primary source: MGI:MGI:102966
See related: Ensembl:ENSMUSG00000071489 AllianceGenome:MGI:102966
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DP; PGD
Summary: Enables prostaglandin D receptor activity and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenosine metabolic process; cellular response to prostaglandin D stimulus; and male sex determination. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR (prostaglandin D2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 1.2), CNS E18 (RPKM 0.5) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 22.59 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (45088692..45096832, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (44851235..44859375, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.
Title: Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.
These findings suggest that prolonged exposure to PGD2 causes the BSM hyperresponsiveness via the DP1 receptor-mediated activation of p38. A sustained increase in PGD2 in the airways might be a cause of the AHR in allergic asthmatics.
Title: Sustained exposure to prostaglandin D(2) augments the contraction induced by acetylcholine via a DP(1) receptor-mediated activation of p38 in bronchial smooth muscle of naive mice.
We demonstrated that enhancing DP1 receptor signaling can exert a preventive and therapeutic effect on development of food allergies by inhibiting infiltration and degranulation of mast cells in the intestines.
Title: Therapeutic potential of D prostanoid receptor 1 signal enhancement in a murine model of food allergy.
PGD2 signaling through the D-prostanoid receptor 1 (DP1) receptor is necessary for optimal microglia/macrophage activation and IFN expression after infection with a neurotropic coronavirus
Title: Virus-induced inflammasome activation is suppressed by prostaglandin D(2)/DP1 signaling.
A role for PGD2 signals acting through PTGDR in suppression of intestinal tumors.
Title: Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR.
Data indicate a PLA2G3-lipocalin-type PGD2 synthase (L-PGDS)-PGD2 receptor DP1 loop that drives mast cell maturation.
Title: Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
PGD(2)-DP signaling reduces vascular permeability both in vivo.
Title: Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway.
platelet DP1 is not present in mice. Despite this, DP1 deletion in mice augmented aneurysm formation and the hypertensive response to Ang II and accelerated atherogenesis and thrombogenesis.
Title: Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.
The present study demonstrates that functional roles of PGD2 and its receptors appear to depend on the nature of the inflammation in chronic skin inflammation, chronic contact hypersensitivity and IgE-mediated chronic allergic skin inflammation
Title: Distinct roles of prostaglandin D2 receptors in chronic skin inflammation.
pain sensitivity was increased in prostaglandin D receptor mutant mice
Title: Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Ptgdr (e-PCR), detects polymorphism
- UniSTS:144289

PMC58788P1 (e-PCR)
- UniSTS:273373

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin D receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin D receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin D receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin J receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenosine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to prostaglandin D stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostaglandin D2 receptor

Names: PGD receptor; PGD2 receptor; prostanoid DP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.