nxf-1 Nuclear RNA export factor 1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: nxf-1
Gene description: Nuclear RNA export factor 1
Primary source: WormBase:WBGene00003834
Locus tag: CELE_C15H11.3
See related: AllianceGenome:WB:WBGene00003834
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in nuclear envelope; nucleolus; and nucleoplasm. Part of nuclear pore. Orthologous to several human genes including NXF1 (nuclear RNA export factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (14411649..14415014, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C15H11.3 (e-PCR)
- UniSTS:309085

C15H11.6 (e-PCR)
- UniSTS:309087

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear RNA export factor 1

NP_001129880.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

14411649..14415014 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001136408.4 → NP_001129880.1 Nuclear RNA export factor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129880.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XVS7

UniProtKB/TrEMBL

B5BM32

Conserved Domains (2) summary

smart00804
Location:550 → 608

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:184 → 226

LRR_NTF; leucine-rich repeat [structural motif]