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Prlr prolactin receptor [ Mus musculus (house mouse) ]

Gene ID: 19116, updated on 21-Apr-2024

Summary

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Official Symbol
Prlrprovided by MGI
Official Full Name
prolactin receptorprovided by MGI
Primary source
MGI:MGI:97763
See related
Ensembl:ENSMUSG00000005268 AllianceGenome:MGI:97763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pr-1; Pr-3; Prlr-rs1
Summary
Enables prolactin receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including gland development; receptor signaling pathway via JAK-STAT; and response to bacterium. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb segment. Used to study familial medullary thyroid carcinoma. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 9.9), liver adult (RPKM 9.8) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 A1; 15 5.23 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10177324..10349276)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10177238..10349190)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene interleukin 7 receptor Neighboring gene sperm flagellar 2 Neighboring gene STARR-seq mESC enhancer starr_37942 Neighboring gene STARR-seq mESC enhancer starr_37943 Neighboring gene STARR-seq mESC enhancer starr_37944 Neighboring gene STARR-seq mESC enhancer starr_37946 Neighboring gene STARR-positive B cell enhancer ABC_E9157 Neighboring gene STARR-seq mESC enhancer starr_37947 Neighboring gene STARR-seq mESC enhancer starr_37948 Neighboring gene STARR-seq mESC enhancer starr_37949 Neighboring gene STARR-seq mESC enhancer starr_37950 Neighboring gene predicted gene, 41268 Neighboring gene predicted gene, 41269 Neighboring gene alanine-glyoxylate aminotransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prolactin signaling modulates stress-induced behavioral responses in a preclinical mouse model of migraine. Mason BN, et al. Headache, 2022 Jan. PMID 34967003, Free PMC Article
  2. Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice. Ramirez-Hernandez G, et al. Front Endocrinol (Lausanne), 2021. PMID 33746901, Free PMC Article
  3. Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse. Georgescu T, et al. J Neuroendocrinol, 2020 Nov. PMID 33034148
  4. Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling. Paige C, et al. J Neurosci, 2020 Sep 9. PMID 32801151, Free PMC Article
  5. The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females. Chen Y, et al. Sci Transl Med, 2020 Feb 5. PMID 32024801, Free PMC Article

See all (189) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance.
    Title: PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance.
  2. [Prolactin and its receptor: From animal models to pituitary pathophysiology].
    Title: [Prolactin and its receptor: From animal models to pituitary pathophysiology].
  3. Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring.
    Title: Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring.
  4. The effect of circadian rhythm on prolactin/PRLR-mediated intracellular signaling profiles in vivo and in vitro.
    Title: The effect of circadian rhythm on prolactin/PRLR-mediated intracellular signaling profiles in vivo and in vitro.
  5. Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice.
    Title: Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice.
  6. Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse.
    Title: Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse.
  7. The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females.
    Title: The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females.
  8. Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling.
    Title: Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling.
  9. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression.
    Title: Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression.
  10. Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.
    Title: Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables prolactin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prolactin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables prolactin receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables prolactin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lactation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mammary gland alveolus development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mammary gland epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mammary gland epithelium development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within prostate gland growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prolactin receptor
Names
PRL-R
prolactin receptor related sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253781.1 → NP_001240710.1  prolactin receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001240710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon and an alternate 3' exon including the coding region and UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK052679, AK054381, BP761592
    Consensus CDS
    CCDS56976.1
    UniProtKB/TrEMBL
    G3UVW6, Q8C7G1
    Related
    ENSMUSP00000121280.2, ENSMUST00000128921.8
    Conserved Domains (2) summary
    cd00063
    Location:122 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:18 → 115
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001253782.2 → NP_001240711.1  prolactin receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001240711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK052679, M22958
    Consensus CDS
    CCDS56975.1
    UniProtKB/TrEMBL
    Q8C7G1
    Related
    ENSMUSP00000122209.2, ENSMUST00000128450.8
    Conserved Domains (2) summary
    cd00063
    Location:122 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:18 → 115
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. NM_011169.5 → NP_035299.4  prolactin receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_035299.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI527408, AK052679, AK054551, AK077980, AK083198, AK087727, AK087749, AK165113, BG087509, DV053280
    Consensus CDS
    CCDS27377.1
    UniProtKB/Swiss-Prot
    P15212, P15213, Q08501, Q62099
    UniProtKB/TrEMBL
    Q99JZ1
    Related
    ENSMUSP00000122219.2, ENSMUST00000124470.8
    Conserved Domains (2) summary
    cd00063
    Location:122 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:18 → 115
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    10177324..10349276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248425.1 → XP_030104285.1  prolactin receptor isoform X2

    UniProtKB/TrEMBL
    G3UVW6, Q8C7G1
    Related
    ENSMUSP00000121935.2, ENSMUST00000137867.8
    Conserved Domains (2) summary
    cd00063
    Location:122 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:18 → 115
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_006520035.1 → XP_006520098.1  prolactin receptor isoform X1

    See identical proteins and their annotated locations for XP_006520098.1

    UniProtKB/Swiss-Prot
    P15212, P15213, Q08501, Q62099
    UniProtKB/TrEMBL
    Q99JZ1
    Conserved Domains (2) summary
    cd00063
    Location:122 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:18 → 115
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_006520034.3 → XP_006520097.1  prolactin receptor isoform X1

    See identical proteins and their annotated locations for XP_006520097.1

    UniProtKB/Swiss-Prot
    P15212, P15213, Q08501, Q62099
    UniProtKB/TrEMBL
    Q99JZ1
    Conserved Domains (2) summary
    cd00063
    Location:122 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:18 → 115
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_006520038.2 → XP_006520101.1  prolactin receptor isoform X3

    See identical proteins and their annotated locations for XP_006520101.1

    UniProtKB/TrEMBL
    Q8C7G1
    Related
    ENSMUSP00000118355.2, ENSMUST00000148257.8
    Conserved Domains (2) summary
    cd00063
    Location:122 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:18 → 115
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. XM_036159267.1 → XP_036015160.1  prolactin receptor isoform X2

    UniProtKB/TrEMBL
    G3UVW6, Q8C7G1
    Conserved Domains (2) summary
    cd00063
    Location:122 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:18 → 115
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  6. XM_006520036.1 → XP_006520099.1  prolactin receptor isoform X1

    See identical proteins and their annotated locations for XP_006520099.1

    UniProtKB/Swiss-Prot
    P15212, P15213, Q08501, Q62099
    UniProtKB/TrEMBL
    Q99JZ1
    Conserved Domains (2) summary
    cd00063
    Location:122 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:18 → 115
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  7. XM_006520037.4 → XP_006520100.1  prolactin receptor isoform X1

    See identical proteins and their annotated locations for XP_006520100.1

    UniProtKB/Swiss-Prot
    P15212, P15213, Q08501, Q62099
    UniProtKB/TrEMBL
    Q99JZ1
    Conserved Domains (2) summary
    cd00063
    Location:122 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:18 → 115
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. XR_383824.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_045590.1: Suppressed sequence

    Description
    NR_045590.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

  2. NR_045591.1: Suppressed sequence

    Description
    NR_045591.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

  3. NR_045592.1: Suppressed sequence

    Description
    NR_045592.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08501.1 GenPept UniProtKB/Swiss-Prot:Q08501

Gene LinkOut

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