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Ppp1cc protein phosphatase 1 catalytic subunit gamma [ Mus musculus (house mouse) ]

Gene ID: 19047, updated on 3-Apr-2024

Summary

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Official Symbol
Ppp1ccprovided by MGI
Official Full Name
protein phosphatase 1 catalytic subunit gammaprovided by MGI
Primary source
MGI:MGI:104872
See related
Ensembl:ENSMUSG00000004455 AllianceGenome:MGI:104872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PP1; PP-1G; dis2m1
Summary
Enables protein serine/threonine phosphatase activity. Involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and protein dephosphorylation. Acts upstream of or within regulation of nucleocytoplasmic transport. Located in mitochondrial outer membrane. Is expressed in several structures, including central nervous system and retina. Orthologous to human PPP1CC (protein phosphatase 1 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 167.5), CNS E11.5 (RPKM 107.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp1cc in Genome Data Viewer
Location:
5 F; 5 62.2 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122296338..122313336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122154967..122175273)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568726 Neighboring gene predicted gene, 52786 Neighboring gene VISTA enhancer mm77 Neighboring gene myosin, light polypeptide 2, regulatory, cardiac, slow Neighboring gene STARR-seq mESC enhancer starr_14271 Neighboring gene coiled-coil domain containing 63 Neighboring gene STARR-positive B cell enhancer ABC_E3613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122595403-122595586 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122595588-122595697 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122634438-122634667 Neighboring gene STARR-seq mESC enhancer starr_14277 Neighboring gene STARR-positive B cell enhancer ABC_E9650 Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122685188-122685492 Neighboring gene tectonic family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E6375 Neighboring gene STARR-positive B cell enhancer ABC_E10345 Neighboring gene RIKEN cDNA 1700112N08 gene Neighboring gene STARR-seq mESC enhancer starr_14278

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase. Dong W, et al. Cell Rep, 2020 Mar 24. PMID 32209465
  2. The protein phosphatase isoform PP1γ1 substitutes for PP1γ2 to support spermatogenesis but not normal sperm function and fertility†. Dudiki T, et al. Biol Reprod, 2019 Mar 1. PMID 30379985, Free PMC Article
  3. Effects of 5-Aza-2'-deoxycytidine on expression of PP1γ in learning and memory. Zhang Z, et al. Biomed Pharmacother, 2016 Dec. PMID 27665473
  4. The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner. Woldemichael BT, et al. Nat Commun, 2016 Aug 25. PMID 27558292, Free PMC Article
  5. Selective ablation of Ppp1cc gene in testicular germ cells causes oligo-teratozoospermia and infertility in mice. Sinha N, et al. Biol Reprod, 2013 Nov. PMID 24089200, Free PMC Article

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis.
    Title: Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis.
  2. Protein Phosphatase 1 gamma Modulates Steady-State BAD Phosphorylation and Murine Platelet Survival.
    Title: Protein Phosphatase 1 γ Modulates Steady-State BAD Phosphorylation and Murine Platelet Survival.
  3. Oscillations in PP1 activity are essential for accurate progression through mammalian oocyte meiosis.
    Title: Oscillations in PP1 activity are essential for accurate progression through mammalian oocyte meiosis.
  4. PP1gamma regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes.
    Title: PP1γ regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes.
  5. Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction.
    Title: Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction.
  6. Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase.
    Title: Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase.
  7. The amount of a testis- and sperm-specific isoform of Ppp1cc2 in the chromatin-binding fraction was substantially less in Hspa4l-null spermatozoa than in wild-type mice. Ppp1cc2 was a substrate of Hsc70 and Hsp70. Hspa4l enhanced the release of Ppp1cc2 from these complexes. Ppp1cc2 then localized to chromatin. Ppp1cc2 dephosphorylated protamine 2 at serine 56.
    Title: Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo.
  8. PP1 promotes dephosphorylation of nNOS serine-852 leading to nitroc oxide and hydrogen peroxide production and endothelium-dependent vasodilation.
    Title: Modulation of nNOS(ser852) phosphorylation and translocation by PKA/PP1 pathway in endothelial cells.
  9. These findings provide novel evidence for a role of miRNAs in memory formation and suggest the implication of PP1 in miRNAs processing in the adult brain.
    Title: The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner.
  10. NEK1 phosphorylates PP1gamma, leading to the dephosphorylation of WAPL, which, in turn, results in its retention on chromosome cores to promote loss of cohesion at the end of prophase I in mammals.
    Title: Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Names
PP1C gamma 1
PP1C gamma 2
protein phosphatase 1C catalytic subunit
NP_001411466.1
NP_001411468.1
NP_001411469.1
NP_001411471.1
NP_001411472.1
NP_001411473.1
NP_001411474.1
NP_001411475.1
NP_001411476.1
NP_001411477.1
NP_001411478.1
NP_001411479.1
NP_001411480.1
NP_001411481.1
NP_038664.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424537.1 → NP_001411466.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127266

  2. NM_001424539.1 → NP_001411468.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127266

  3. NM_001424540.1 → NP_001411469.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127266

  4. NM_001424542.1 → NP_001411471.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC127266

  5. NM_001424543.1 → NP_001411472.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC127266

  6. NM_001424544.1 → NP_001411473.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC127266

  7. NM_001424545.1 → NP_001411474.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC127266

  8. NM_001424546.1 → NP_001411475.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC127266

  9. NM_001424547.1 → NP_001411476.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC127266

  10. NM_001424548.1 → NP_001411477.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC127266

  11. NM_001424549.1 → NP_001411478.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC127266

  12. NM_001424550.1 → NP_001411479.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC127266

  13. NM_001424551.1 → NP_001411480.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC127266

  14. NM_001424552.1 → NP_001411481.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC127266

  15. NM_013636.5 → NP_038664.2  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_038664.2

    Status: VALIDATED

    Source sequence(s)
    AC127266
    Consensus CDS
    CCDS19643.1
    UniProtKB/Swiss-Prot
    O09186, O09189, P37139, P63087, Q64679
    UniProtKB/TrEMBL
    Q3U7K1, Q6ZWM8
    Related
    ENSMUSP00000099587.5, ENSMUST00000102528.11
    Conserved Domains (1) summary
    cd07414
    Location:8 → 298
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RNA

  1. NR_156471.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127266
    Related
    ENSMUST00000132555.8

  2. NR_156472.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127266
    Related
    ENSMUST00000128309.8

  3. NR_188781.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127266

  4. NR_188782.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127266

  5. NR_188783.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127266

  6. NR_188784.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127266

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122296338..122313336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63087.1 GenPept UniProtKB/Swiss-Prot:P63087

Gene LinkOut

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Chemical Information
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