U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cyh-1 Cyclin-H [ Caenorhabditis elegans ]

Gene ID: 190078, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
cyh-1
Gene description
Cyclin-H
Primary source
WormBase:WBGene00021714
Locus tag
CELE_Y49F6B.1
See related
AllianceGenome:WB:WBGene00021714
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in phosphorylation of RNA polymerase II C-terminal domain and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of transcription factor TFIIK complex. Predicted to be active in nucleus. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (3505017..3510597)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Cuticle collagen 71 Neighboring gene ncRNA Neighboring gene Fcf2 pre-rRNA processing C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene TransThyretin-Related family domain Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos. Cowan CR, et al. Nat Cell Biol, 2006 Dec. PMID 17115027
  2. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIK complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Cyclin-H
NP_001379352.1
  • Partially confirmed by transcript evidence
NP_001379353.1
  • Partially confirmed by transcript evidence
NP_001379354.1
  • Confirmed by transcript evidence
NP_001379355.1
  • Partially confirmed by transcript evidence
NP_001379356.1
  • Partially confirmed by transcript evidence
NP_494564.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    3505017..3510597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062163.5 → NP_494564.2  Cyclin-H [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494564.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4U0
    Conserved Domains (2) summary
    cd00043
    Location:64 → 147
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam16899
    Location:159 → 270
    Cyclin_C_2; Cyclin C-terminal domain

  2. NM_001393040.1 → NP_001379352.1  Cyclin-H [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7R9SUL6
    Conserved Domains (2) summary
    cd20524
    Location:3 → 157
    CYCLIN_CCNH_rpt1; first cyclin box found in cyclin-H (CCNH) and similar proteins
    cd20525
    Location:160 → 310
    CYCLIN_CCNH_rpt2; second cyclin box found in cyclin-H (CCNH) and similar proteins

  3. NM_001393041.1 → NP_001379355.1  Cyclin-H [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7R9SUM0
    Conserved Domains (2) summary
    cd20524
    Location:3 → 157
    CYCLIN_CCNH_rpt1; first cyclin box found in cyclin-H (CCNH) and similar proteins
    cd20525
    Location:160 → 308
    CYCLIN_CCNH_rpt2; second cyclin box found in cyclin-H (CCNH) and similar proteins

  4. NM_001393042.1 → NP_001379353.1  Cyclin-H [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7R9SUI7
    Conserved Domains (2) summary
    cd20524
    Location:3 → 156
    CYCLIN_CCNH_rpt1; first cyclin box found in cyclin-H (CCNH) and similar proteins
    cd20525
    Location:159 → 309
    CYCLIN_CCNH_rpt2; second cyclin box found in cyclin-H (CCNH) and similar proteins

  5. NM_001393043.1 → NP_001379356.1  Cyclin-H [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7R9XND1
    Conserved Domains (2) summary
    cd20524
    Location:3 → 156
    CYCLIN_CCNH_rpt1; first cyclin box found in cyclin-H (CCNH) and similar proteins
    cd20525
    Location:159 → 307
    CYCLIN_CCNH_rpt2; second cyclin box found in cyclin-H (CCNH) and similar proteins

  6. NM_001393044.1 → NP_001379354.1  Cyclin-H [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7R9SW78
    Conserved Domains (2) summary
    cd20524
    Location:3 → 154
    CYCLIN_CCNH_rpt1; first cyclin box found in cyclin-H (CCNH) and similar proteins
    cd20525
    Location:157 → 307
    CYCLIN_CCNH_rpt2; second cyclin box found in cyclin-H (CCNH) and similar proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous