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Pld1 phospholipase D1 [ Mus musculus (house mouse) ]

Gene ID: 18805, updated on 11-Apr-2024

Summary

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Official Symbol
Pld1provided by MGI
Official Full Name
phospholipase D1provided by MGI
Primary source
MGI:MGI:109585
See related
Ensembl:ENSMUSG00000027695 AllianceGenome:MGI:109585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pld1a; Pld1b; mPLD1
Summary
Predicted to enable phospholipase D activity. Acts upstream of or within defense response to Gram-positive bacterium. Predicted to be located in several cellular components, including Golgi cisterna; cytoplasmic vesicle; and lamellipodium. Predicted to be active in cholinergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 A3; 3 11.15 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (27992636..28187388)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (27938459..28133362)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07251 Neighboring gene predicted gene, 42195 Neighboring gene predicted gene, 57707 Neighboring gene STARR-seq mESC enhancer starr_07254 Neighboring gene STARR-seq mESC enhancer starr_07256 Neighboring gene STARR-seq mESC enhancer starr_07258 Neighboring gene STARR-seq mESC enhancer starr_07259 Neighboring gene predicted gene, 42196 Neighboring gene predicted gene, 54170 Neighboring gene TRAF2 and NCK interacting kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina. Barber CN, et al. J Lipid Res, 2022 Aug. PMID 35764123, Free PMC Article
  2. PLD1 promotes tumor invasion by regulation of MMP-13 expression via NF-κB signaling in bladder cancer. Nagumo Y, et al. Cancer Lett, 2021 Jul 28. PMID 33945837
  3. Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, β-catenin-osteoprotegerin, PPAR-γ and C/EBPα signaling axis. Kang DW, et al. Biochim Biophys Acta Mol Basis Dis, 2021 May 1. PMID 33497821
  4. VU0155069 inhibits inflammasome activation independent of phospholipase D1 activity. Lee SK, et al. Sci Rep, 2019 Oct 4. PMID 31586128, Free PMC Article
  5. Phospholipase D1 regulation of TNF-alpha protects against responses to LPS. Urbahn MA, et al. Sci Rep, 2018 Jul 3. PMID 29968773, Free PMC Article

See all (125) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells.
    Title: Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells.
  2. Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina.
    Title: Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina.
  3. RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.
    Title: RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.
  4. PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.
    Title: PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.
  5. PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury.
    Title: PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury.
  6. Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, beta-catenin-osteoprotegerin, PPAR-gamma and C/EBPalpha signaling axis.
    Title: Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, β-catenin-osteoprotegerin, PPAR-γ and C/EBPα signaling axis.
  7. Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.
    Title: Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.
  8. Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation.
    Title: Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation.
  9. Phospholipase D1 inhibition sensitizes glioblastoma to temozolomide and suppresses its tumorigenicity.
    Title: Phospholipase D1 inhibition sensitizes glioblastoma to temozolomide and suppresses its tumorigenicity.
  10. Suppressing aberrant phospholipase D1 signaling in 3xTg Alzheimer's disease mouse model promotes synaptic resilience.
    Title: Suppressing aberrant phospholipase D1 signaling in 3xTg Alzheimer's disease mouse model promotes synaptic resilience.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (9)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase D activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase D activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase D activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to nutrient ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within phospholipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in phospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microvillus assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microvillus assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane region IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholipase D1
Names
choline phosphatase 1
phosphatidylcholine-hydrolyzing phospholipase D1
NP_001157528.1
NP_001355596.1
NP_001397459.1
NP_001397460.1
NP_001397461.1
NP_032901.2
XP_017174978.1
XP_017174979.1
XP_017174980.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164056.2 → NP_001157528.1  phospholipase D1 isoform 1

    See identical proteins and their annotated locations for NP_001157528.1

    Status: VALIDATED

    Source sequence(s)
    AC114987, AC132149
    Consensus CDS
    CCDS17275.1
    UniProtKB/Swiss-Prot
    O35911, Q9Z280
    UniProtKB/TrEMBL
    Q6NVF2
    Related
    ENSMUSP00000113810.2, ENSMUST00000120834.8
    Conserved Domains (1) summary
    PLN02866
    Location:82 → 1021
    PLN02866; phospholipase D

  2. NM_001368667.2 → NP_001355596.1  phospholipase D1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114987, AC132149
    Consensus CDS
    CCDS89617.1
    UniProtKB/Swiss-Prot
    O35911, Q9Z280
    UniProtKB/TrEMBL
    D6RH77
    Related
    ENSMUSP00000118727.3, ENSMUST00000123539.8
    Conserved Domains (1) summary
    PLN02866
    Location:82 → 1059
    PLN02866; phospholipase D

  3. NM_001410530.1 → NP_001397459.1  phospholipase D1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114987, AC132149
    UniProtKB/TrEMBL
    D6RH77

  4. NM_001410531.1 → NP_001397460.1  phospholipase D1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114987, AC132149
    UniProtKB/TrEMBL
    Q6NVF2

  5. NM_001410532.1 → NP_001397461.1  phospholipase D1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114987, AC132149
    UniProtKB/TrEMBL
    Q6NVF2

  6. NM_008875.5 → NP_032901.2  phospholipase D1 isoform 1

    See identical proteins and their annotated locations for NP_032901.2

    Status: VALIDATED

    Source sequence(s)
    AC114987, AC132149
    Consensus CDS
    CCDS17275.1
    UniProtKB/Swiss-Prot
    O35911, Q9Z280
    UniProtKB/TrEMBL
    Q6NVF2
    Related
    ENSMUSP00000064694.5, ENSMUST00000067757.11
    Conserved Domains (1) summary
    PLN02866
    Location:82 → 1021
    PLN02866; phospholipase D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    27992636..28187388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319490.3 → XP_017174979.1  phospholipase D1 isoform X1

    UniProtKB/Swiss-Prot
    O35911, Q9Z280
    UniProtKB/TrEMBL
    D6RH77
    Conserved Domains (1) summary
    PLN02866
    Location:82 → 1059
    PLN02866; phospholipase D

  2. XM_017319489.3 → XP_017174978.1  phospholipase D1 isoform X1

    UniProtKB/Swiss-Prot
    O35911, Q9Z280
    UniProtKB/TrEMBL
    D6RH77
    Conserved Domains (1) summary
    PLN02866
    Location:82 → 1059
    PLN02866; phospholipase D

  3. XM_017319491.3 → XP_017174980.1  phospholipase D1 isoform X1

    UniProtKB/Swiss-Prot
    O35911, Q9Z280
    UniProtKB/TrEMBL
    D6RH77
    Conserved Domains (1) summary
    PLN02866
    Location:82 → 1059
    PLN02866; phospholipase D
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z280.1 GenPept UniProtKB/Swiss-Prot:Q9Z280

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