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Plcb4 phospholipase C, beta 4 [ Mus musculus (house mouse) ]

Gene ID: 18798, updated on 21-Apr-2024

Summary

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Official Symbol
Plcb4provided by MGI
Official Full Name
phospholipase C, beta 4provided by MGI
Primary source
MGI:MGI:107464
See related
Ensembl:ENSMUSG00000039943 AllianceGenome:MGI:107464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930039J07Rik; C230058B11Rik
Summary
Predicted to enable mitogen-activated protein kinase binding activity and phosphatidylinositol phospholipase C activity. Involved in modulation of chemical synaptic transmission. Located in several cellular components, including glutamatergic synapse; parallel fiber to Purkinje cell synapse; and smooth endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLCB4 (phospholipase C beta 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 32.1), cerebellum adult (RPKM 16.4) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F3; 2 66.64 cM
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (135500523..135856522)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (135658603..136014602)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9630028H03 gene Neighboring gene STARR-seq mESC enhancer starr_05784 Neighboring gene pluripotency associated transcript 3 Neighboring gene STARR-seq mESC enhancer starr_05788 Neighboring gene predicted gene, 54134 Neighboring gene STARR-seq mESC enhancer starr_05793 Neighboring gene predicted gene 14210 Neighboring gene STARR-seq mESC enhancer starr_05794 Neighboring gene STARR-seq mESC enhancer starr_05795 Neighboring gene predicted gene, 54133 Neighboring gene predicted gene, 26227 Neighboring gene lysosomal-associated membrane protein family, member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation. Hong J, et al. Sci Rep, 2020 Jun 1. PMID 32483199, Free PMC Article
  2. Neural circuits underlying a psychotherapeutic regimen for fear disorders. Baek J, et al. Nature, 2019 Feb. PMID 30760920
  3. Bidirectional modulation of fear extinction by mediodorsal thalamic firing in mice. Lee S, et al. Nat Neurosci, 2011 Dec 25. PMID 22197828
  4. Phospholipase C beta 4 in the medial septum controls cholinergic theta oscillations and anxiety behaviors. Shin J, et al. J Neurosci, 2009 Dec 9. PMID 20007462, Free PMC Article
  5. Deletion of phospholipase C beta4 in thalamocortical relay nucleus leads to absence seizures. Cheong E, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 19955421, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SENP2-PLCbeta4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.
    Title: SENP2-PLCβ4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.
  2. Destabilization of light NREM sleep by thalamic PLCbeta4 deletion impairs sleep-dependent memory consolidation.
    Title: Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation.
  3. Thrombosis suppression by heterozygous Plcb4 loss of function was confirmed through analysis of an independent, CRISPR/Cas9-induced Plcb4 mutation in transgenic mice.
    Title: Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.
  4. The results of our study showed that thalamic mGluR1-PLCbeta4 pathway was critical in controlling sleep architecture.
    Title: The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture.
  5. Tnis study demonistrated that plc beta4 distribuate in mice cerebellum
    Title: Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.
  6. Presence of PLCbeta(4) in the heart and in HL-1 cardiomyocytes showing a different species-dependent pattern of expression of the PLCbeta((1-4)) transcripts.
    Title: Phospholipase Cbeta4 isozyme is expressed in human, rat, and murine heart left ventricles and in HL-1 cardiomyocytes.
  7. impaired LGNd relay, possibly mediated via group-1 mGluR, may underlie irregular sleep sequences and ultradian body temperature rhythms in PLC-beta4-/- mice
    Title: Phospholipase C-beta4 is essential for the progression of the normal sleep sequence and ultradian body temperature rhythms in mice.
  8. deletion of thalamic PLCbeta4 leads to the genesis of absence seizures
    Title: Deletion of phospholipase C beta4 in thalamocortical relay nucleus leads to absence seizures.
  9. These findings suggest that (1) PLC-beta 4 in the medial septum is involved in controlling cholinergic theta oscillation and (2) cholinergic theta rhythm plays a critical role in suppressing anxiety.
    Title: Phospholipase C beta 4 in the medial septum controls cholinergic theta oscillations and anxiety behaviors.
  10. In this study identify phospholipase C (PLC) beta4 as an antigenic marker of a novel subset of unipolar brush cells. Double immunolabeling reveals that most members of the mGluR1alpha subset also express PLCbeta4.
    Title: Phospholipase Cbeta4 expression identifies a novel subset of unipolar brush cells in the adult mouse cerebellum.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating endothelin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in parallel fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in smooth endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in smooth endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in smooth endoplasmic reticulum IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
NP_001342082.1
NP_001342083.1
NP_001342084.1
NP_001342085.1
NP_038857.1
XP_006498999.1
XP_006499000.1
XP_006499001.1
XP_006499002.1
XP_006499004.1
XP_006499006.1
XP_006499008.1
XP_006499009.1
XP_006499010.1
XP_006499011.1
XP_006499013.1
XP_011237659.1
XP_011237661.1
XP_030104392.1
XP_030104397.1
XP_030104399.1
XP_036015472.1
XP_036015477.1
XP_036015478.1
XP_036015483.1
XP_036015485.1
XP_036015489.1
XP_036015500.1
XP_036015503.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355153.1 → NP_001342082.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL928798, AL929052, AL935301
    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:847 → 1194
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)

  2. NM_001355154.1 → NP_001342083.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate 3' exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AL928798, AL935301
    Consensus CDS
    CCDS16788.1
    UniProtKB/TrEMBL
    Q91UZ1, V9GXQ9
    Related
    ENSMUSP00000038409.5, ENSMUST00000035646.11
    Conserved Domains (6) summary
    PTZ00121
    Location:839 → 1170
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)

  3. NM_001355155.1 → NP_001342084.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame 5' exon and lacks an alternate 3' exon compared to variant 1, that causes a frameshift. The resulting isoform (c) has an alternate internal segment and a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL928798, AL929052, AL935301
    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:851 → 1182
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  4. NM_001355156.1 → NP_001342085.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate 5' exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AL928798, AL929052, AL935301
    Conserved Domains (4) summary
    PTZ00121
    Location:579 → 926
    PTZ00121; MAEBL; Provisional
    cd08591
    Location:44 → 400
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:16 → 539
    PLN02228; Phosphoinositide phospholipase C
    pfam06631
    Location:646 → 687
    DUF1154; Protein of unknown function (DUF1154)

  5. NM_013829.3 → NP_038857.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

    See identical proteins and their annotated locations for NP_038857.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 3' exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AL928798, AL929052, AL935301
    Consensus CDS
    CCDS16788.1
    UniProtKB/TrEMBL
    Q91UZ1, V9GXQ9
    Related
    ENSMUSP00000105736.2, ENSMUST00000110109.8
    Conserved Domains (6) summary
    PTZ00121
    Location:839 → 1170
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    135500523..135856522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239359.4 → XP_011237661.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    See identical proteins and their annotated locations for XP_011237661.1

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:860 → 1207
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:715 → 831
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 681
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:927 → 968
    DUF1154; Protein of unknown function (DUF1154)

  2. XM_036159592.1 → XP_036015485.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:847 → 1194
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)

  3. XM_030248537.2 → XP_030104397.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:848 → 1195
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:703 → 819
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 669
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:915 → 956
    DUF1154; Protein of unknown function (DUF1154)

  4. XM_006498936.4 → XP_006498999.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    See identical proteins and their annotated locations for XP_006498999.1

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:860 → 1207
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:715 → 831
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 681
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:927 → 968
    DUF1154; Protein of unknown function (DUF1154)

  5. XM_006498941.2 → XP_006499004.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:852 → 1183
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:715 → 831
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 681
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:927 → 968
    DUF1154; Protein of unknown function (DUF1154)

  6. XM_006498943.3 → XP_006499006.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X6

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:840 → 1171
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:703 → 819
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 669
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:915 → 956
    DUF1154; Protein of unknown function (DUF1154)

  7. XM_011239357.4 → XP_011237659.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    See identical proteins and their annotated locations for XP_011237659.1

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:860 → 1207
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:715 → 831
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 681
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:927 → 968
    DUF1154; Protein of unknown function (DUF1154)

  8. XM_006498939.4 → XP_006499002.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:848 → 1195
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:703 → 819
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 669
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:915 → 956
    DUF1154; Protein of unknown function (DUF1154)

  9. XM_006498938.4 → XP_006499001.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  10. XM_036159579.1 → XP_036015472.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:860 → 1207
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:715 → 831
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 681
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:927 → 968
    DUF1154; Protein of unknown function (DUF1154)

  11. XM_036159584.1 → XP_036015477.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:860 → 1207
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:715 → 831
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 681
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:927 → 968
    DUF1154; Protein of unknown function (DUF1154)

  12. XM_036159610.1 → XP_036015503.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X11

    Conserved Domains (4) summary
    PTZ00121
    Location:591 → 938
    PTZ00121; MAEBL; Provisional
    cd08591
    Location:44 → 412
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:16 → 551
    PLN02228; Phosphoinositide phospholipase C
    pfam06631
    Location:658 → 699
    DUF1154; Protein of unknown function (DUF1154)

  13. XM_036159585.1 → XP_036015478.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  14. XM_036159596.1 → XP_036015489.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:847 → 1194
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)

  15. XM_036159590.1 → XP_036015483.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:848 → 1195
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:703 → 819
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 669
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:915 → 956
    DUF1154; Protein of unknown function (DUF1154)

  16. XM_030248532.2 → XP_030104392.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:860 → 1207
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:715 → 831
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 681
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:927 → 968
    DUF1154; Protein of unknown function (DUF1154)

  17. XM_006498937.5 → XP_006499000.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    See identical proteins and their annotated locations for XP_006499000.1

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:860 → 1207
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:715 → 831
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 681
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:927 → 968
    DUF1154; Protein of unknown function (DUF1154)

  18. XM_030248539.2 → XP_030104399.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:847 → 1194
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)

  19. XM_006498945.5 → XP_006499008.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X7

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (6) summary
    PTZ00121
    Location:747 → 1094
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:602 → 718
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:199 → 568
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd16211
    Location:35 → 187
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:814 → 855
    DUF1154; Protein of unknown function (DUF1154)
    cl17171
    Location:1 → 30
    PH-like; Pleckstrin homology-like domain

  20. XM_036159607.1 → XP_036015500.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X10

    Conserved Domains (4) summary
    PTZ00121
    Location:592 → 939
    PTZ00121; MAEBL; Provisional
    cd08591
    Location:44 → 413
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:16 → 552
    PLN02228; Phosphoinositide phospholipase C
    pfam06631
    Location:659 → 700
    DUF1154; Protein of unknown function (DUF1154)

  21. XM_006498947.5 → XP_006499010.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X8

    See identical proteins and their annotated locations for XP_006499010.1

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (5) summary
    PTZ00121
    Location:717 → 1064
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:572 → 688
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:169 → 538
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd16211
    Location:5 → 157
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:784 → 825
    DUF1154; Protein of unknown function (DUF1154)

  22. XM_006498946.5 → XP_006499009.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X8

    See identical proteins and their annotated locations for XP_006499009.1

    UniProtKB/TrEMBL
    V9GXQ9
    Conserved Domains (5) summary
    PTZ00121
    Location:717 → 1064
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:572 → 688
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:169 → 538
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd16211
    Location:5 → 157
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:784 → 825
    DUF1154; Protein of unknown function (DUF1154)

  23. XM_006498948.5 → XP_006499011.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X12

    Conserved Domains (6) summary
    PTZ00121
    Location:693 → 1040
    PTZ00121; MAEBL; Provisional
    cd08591
    Location:145 → 514
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:117 → 653
    PLN02228; Phosphoinositide phospholipase C
    cd15898
    Location:100 → 133
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:82 → 133
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam06631
    Location:760 → 801
    DUF1154; Protein of unknown function (DUF1154)

  24. XM_006498950.4 → XP_006499013.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X9

    Conserved Domains (6) summary
    PTZ00121
    Location:613 → 960
    PTZ00121; MAEBL; Provisional
    cd08591
    Location:65 → 434
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:37 → 573
    PLN02228; Phosphoinositide phospholipase C
    cd15898
    Location:20 → 53
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:2 → 53
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam06631
    Location:680 → 721
    DUF1154; Protein of unknown function (DUF1154)
Nucleotide Protein Strain
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