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EBF1 EBF transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 1879, updated on 3-Apr-2024

Summary

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Official Symbol
EBF1provided by HGNC
Official Full Name
EBF transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:3126
See related
Ensembl:ENSG00000164330 MIM:164343; AllianceGenome:HGNC:3126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EBF; COE1; OLF1; O/E-1
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in fat (RPKM 3.2), placenta (RPKM 0.8) and 17 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
5q33.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (158695920..159099916, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (159224860..159628711, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (158122928..158526924, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2227 Neighboring gene uncharacterized LOC124901122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23533 Neighboring gene Sharpr-MPRA regulatory region 1261 Neighboring gene VISTA enhancer hs1208 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:158067088-158067611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23535 Neighboring gene NANOG hESC enhancer GRCh37_chr5:158124779-158125433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158139245-158139745 Neighboring gene VISTA enhancer hs813 Neighboring gene NANOG hESC enhancer GRCh37_chr5:158164501-158165077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23536 Neighboring gene VISTA enhancer hs230 Neighboring gene NANOG hESC enhancer GRCh37_chr5:158378905-158379562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23537 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:158384828-158385690 Neighboring gene NANOG hESC enhancer GRCh37_chr5:158403034-158403551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16567 Neighboring gene VISTA enhancer hs1022 Neighboring gene VISTA enhancer hs1117 Neighboring gene VISTA enhancer hs1123 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:158522773-158523666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158524561-158525454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16568 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:158527204-158527832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158527833-158528459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158531040-158531945 Neighboring gene uncharacterized LOC107986467 Neighboring gene long intergenic non-protein coding RNA 2202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23540 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:158588140-158589339 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158634672-158635327 Neighboring gene uncharacterized LOC107986468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23544 Neighboring gene ring finger protein 145

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. EBF1 is expressed in pericytes and contributes to pericyte cell commitment. Pagani F, et al. Histochem Cell Biol, 2021 Oct. PMID 34272603, Free PMC Article
  2. Plasma EBF1 as a Novel Biomarker for Postmenopausal Osteoporosis. He S, et al. J Clin Densitom, 2022 Apr-Jun. PMID 34272166
  3. A Prion-like Domain in Transcription Factor EBF1 Promotes Phase Separation and Enables B Cell Programming of Progenitor Chromatin. Wang Y, et al. Immunity, 2020 Dec 15. PMID 33159853
  4. Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants. Singh A, et al. Transl Psychiatry, 2020 Oct 20. PMID 33077726, Free PMC Article
  5. EBF1-Correlated Long Non-coding RNA Transcript Levels in 3rd Trimester Maternal Blood and Risk of Spontaneous Preterm Birth. Zhou G, et al. Reprod Sci, 2021 Feb. PMID 32959224

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EBF1, PAX5, and MYC: regulation on B cell development and association with hematologic neoplasms.
    Title: EBF1, PAX5, and MYC: regulation on B cell development and association with hematologic neoplasms.
  2. RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte Meiosis Pathway in Bone Metastases of Bladder Urothelial Carcinoma.
    Title: RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte Meiosis Pathway in Bone Metastases of Bladder Urothelial Carcinoma.
  3. Caveolin-1 rs1997623 Single Nucleotide Polymorphism Creates a New Binding Site for the Early B-Cell Factor 1 That Instigates Adipose Tissue CAV1 Protein Overexpression.
    Title: Caveolin-1 rs1997623 Single Nucleotide Polymorphism Creates a New Binding Site for the Early B-Cell Factor 1 That Instigates Adipose Tissue CAV1 Protein Overexpression.
  4. EBF1 promotes triple-negative breast cancer progression by surveillance of the HIF1alpha pathway.
    Title: EBF1 promotes triple-negative breast cancer progression by surveillance of the HIF1α pathway.
  5. EBNA2-EBF1 complexes promote MYC expression and metabolic processes driving S-phase progression of Epstein-Barr virus-infected B cells.
    Title: EBNA2-EBF1 complexes promote MYC expression and metabolic processes driving S-phase progression of Epstein-Barr virus-infected B cells.
  6. EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA.
    Title: EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA.
  7. Plasma EBF1 as a Novel Biomarker for Postmenopausal Osteoporosis.
    Title: Plasma EBF1 as a Novel Biomarker for Postmenopausal Osteoporosis.
  8. EBF1 is expressed in pericytes and contributes to pericyte cell commitment.
    Title: EBF1 is expressed in pericytes and contributes to pericyte cell commitment.
  9. Maternal blood EBF1-based microRNA transcripts as biomarkers for detecting risk of spontaneous preterm birth: a nested case-control study.
    Title: Maternal blood EBF1-based microRNA transcripts as biomarkers for detecting risk of spontaneous preterm birth: a nested case-control study.
  10. EBF1-Correlated Long Non-coding RNA Transcript Levels in 3rd Trimester Maternal Blood and Risk of Spontaneous Preterm Birth.
    Title: EBF1-Correlated Long Non-coding RNA Transcript Levels in 3rd Trimester Maternal Blood and Risk of Spontaneous Preterm Birth.
Submit: New GeneRIF Correction See all GeneRIFs (58)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.
EBI GWAS Catalog
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
EBI GWAS Catalog
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
EBI GWAS Catalog
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
EBI GWAS Catalog
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
EBI GWAS Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39389, FLJ41763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor COE1
Names
Collier, Olf and EBF transcription factor 1
early B cell factor 1
olfactory neuronal transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290360.3 → NP_001277289.1  transcription factor COE1 isoform 1

    See identical proteins and their annotated locations for NP_001277289.1

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC134043, AK304438, BM802733, DA485473
    UniProtKB/TrEMBL
    A8K0Z7
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  2. NM_001324101.2 → NP_001311030.1  transcription factor COE1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    A8K0Z7
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  3. NM_001324103.2 → NP_001311032.1  transcription factor COE1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    A8K0Z7
    Conserved Domains (3) summary
    cd01175
    Location:262 → 346
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:347 → 390
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  4. NM_001324106.2 → NP_001311035.1  transcription factor COE1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    A8K0Z7
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  5. NM_001324107.2 → NP_001311036.1  transcription factor COE1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    A8K0Z7
    Conserved Domains (3) summary
    cd01175
    Location:255 → 339
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:340 → 383
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  6. NM_001324108.2 → NP_001311037.1  transcription factor COE1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    A8K0Z7
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  7. NM_001324109.2 → NP_001311038.1  transcription factor COE1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    A8K0Z7
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  8. NM_001324111.2 → NP_001311040.1  transcription factor COE1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    B4E172
    Related
    ENST00000519739.5
    Conserved Domains (3) summary
    cd01175
    Location:130 → 214
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:215 → 258
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    cl17007
    Location:1 → 114
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

  9. NM_001364155.2 → NP_001351084.1  transcription factor COE1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    A8K0Z7
    Related
    ENSP00000428020.1, ENST00000517373.1
    Conserved Domains (3) summary
    cd01175
    Location:262 → 346
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:347 → 390
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  10. NM_001364156.2 → NP_001351085.1  transcription factor COE1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    A8K0Z7
    Conserved Domains (3) summary
    cd11606
    Location:7 → 209
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
    cd01175
    Location:224 → 308
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:309 → 352
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  11. NM_001364157.2 → NP_001351086.1  transcription factor COE1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    A8K0Z7
    Conserved Domains (3) summary
    cd11606
    Location:7 → 209
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
    cd01175
    Location:225 → 309
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:310 → 353
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  12. NM_001364158.2 → NP_001351087.1  transcription factor COE1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    B4E172
    Conserved Domains (3) summary
    cd01175
    Location:121 → 205
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:206 → 249
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    cl17007
    Location:1 → 114
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

  13. NM_001364159.2 → NP_001351088.1  transcription factor COE1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC008442, AC008640, AC134043, AC140770
    UniProtKB/TrEMBL
    B4E172
    Related
    ENST00000519890.5
    Conserved Domains (3) summary
    cd01175
    Location:129 → 213
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:214 → 257
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    cl17007
    Location:1 → 114
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

  14. NM_024007.5 → NP_076870.1  transcription factor COE1 isoform 2

    See identical proteins and their annotated locations for NP_076870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is one aa shorter compared to isoform 1.
    Source sequence(s)
    AC008442, AC134043, BC038805, BM802733, DA485473
    Consensus CDS
    CCDS4343.1
    UniProtKB/Swiss-Prot
    Q8IW11, Q9UH73
    UniProtKB/TrEMBL
    A8K0Z7
    Related
    ENSP00000322898.6, ENST00000313708.11
    Conserved Domains (3) summary
    cd01175
    Location:262 → 346
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:347 → 390
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  15. NM_182708.3 → NP_874367.1  transcription factor COE1 isoform 3

    See identical proteins and their annotated locations for NP_874367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses alternate in-frame splice junctions at the ends of two exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC008442, AC134043, BC041178, BM802733, DA485473
    Consensus CDS
    CCDS78081.1
    UniProtKB/TrEMBL
    A8K0Z7
    Related
    ENSP00000370029.4, ENST00000380654.8
    Conserved Domains (3) summary
    cd01175
    Location:231 → 315
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 224
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:316 → 359
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    158695920..159099916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416890.1 → XP_047272846.1  transcription factor COE1 isoform X5

  2. XM_047416889.1 → XP_047272845.1  transcription factor COE1 isoform X4

  3. XM_047416891.1 → XP_047272847.1  transcription factor COE1 isoform X8

  4. XM_017009194.2 → XP_016864683.1  transcription factor COE1 isoform X1

    UniProtKB/TrEMBL
    A8K0Z7
    Conserved Domains (3) summary
    cd01175
    Location:255 → 339
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:340 → 383
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  5. XM_024454390.2 → XP_024310158.1  transcription factor COE1 isoform X6

    UniProtKB/TrEMBL
    B4E172
    Conserved Domains (3) summary
    cd01175
    Location:130 → 214
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    cl17007
    Location:1 → 114
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
    pfam16423
    Location:215 → 258
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  6. XM_047416888.1 → XP_047272844.1  transcription factor COE1 isoform X3

  7. XM_017009197.2 → XP_016864686.1  transcription factor COE1 isoform X2

    UniProtKB/TrEMBL
    A8K0Z7

  8. XM_024454391.2 → XP_024310159.1  transcription factor COE1 isoform X6

    UniProtKB/TrEMBL
    B4E172
    Conserved Domains (3) summary
    cd01175
    Location:130 → 214
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    cl17007
    Location:1 → 114
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
    pfam16423
    Location:215 → 258
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  9. XM_017009200.3 → XP_016864689.1  transcription factor COE1 isoform X7

    UniProtKB/TrEMBL
    B4E172
    Conserved Domains (3) summary
    cd01175
    Location:56 → 140
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:141 → 184
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    cl17007
    Location:1 → 40
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

  10. XM_017009199.2 → XP_016864688.1  transcription factor COE1 isoform X7

    UniProtKB/TrEMBL
    B4E172
    Conserved Domains (3) summary
    cd01175
    Location:56 → 140
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:141 → 184
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    cl17007
    Location:1 → 40
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

  11. XM_017009203.2 → XP_016864692.1  transcription factor COE1 isoform X10

  12. XM_017009202.2 → XP_016864691.1  transcription factor COE1 isoform X9

  13. XM_047416892.1 → XP_047272848.1  transcription factor COE1 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    159224860..159628711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351962.1 → XP_054207937.1  transcription factor COE1 isoform X5

  2. XM_054351961.1 → XP_054207936.1  transcription factor COE1 isoform X4

  3. XM_054351967.1 → XP_054207942.1  transcription factor COE1 isoform X8

  4. XM_054351958.1 → XP_054207933.1  transcription factor COE1 isoform X1

  5. XM_054351964.1 → XP_054207939.1  transcription factor COE1 isoform X6

  6. XM_054351963.1 → XP_054207938.1  transcription factor COE1 isoform X6

  7. XM_054351960.1 → XP_054207935.1  transcription factor COE1 isoform X3

  8. XM_054351959.1 → XP_054207934.1  transcription factor COE1 isoform X2

  9. XM_054351966.1 → XP_054207941.1  transcription factor COE1 isoform X7

  10. XM_054351965.1 → XP_054207940.1  transcription factor COE1 isoform X7

  11. XM_054351969.1 → XP_054207944.1  transcription factor COE1 isoform X10

  12. XM_054351968.1 → XP_054207943.1  transcription factor COE1 isoform X9

  13. XM_054351970.1 → XP_054207945.1  transcription factor COE1 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UH73.2 GenPept UniProtKB/Swiss-Prot:Q9UH73

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