Prkd1 protein kinase D1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prkd1provided by MGI
Official Full Name: protein kinase D1provided by MGI
Primary source: MGI:MGI:99879
See related: Ensembl:ENSMUSG00000002688 AllianceGenome:MGI:99879
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PKD; PKD1; Pkcm; Prkcm; nPKC-D1; nPKC-mu
Summary: Predicted to enable identical protein binding activity and protein kinase C activity. Involved in several processes, including positive regulation of osteoblast differentiation; positive regulation of protein import into nucleus; and regulation of keratinocyte proliferation. Acts upstream of or within regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including cell cortex; cell-cell junction; and trans-Golgi network. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Orthologous to human PRKD1 (protein kinase D1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 3.1), subcutaneous fat pad adult (RPKM 2.4) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 B3; 12 21.78 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (50388009..50696075, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (50341226..50649271, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein Kinase D Plays a Crucial Role in Maintaining Cardiac Homeostasis by Regulating Post-Translational Modifications of Myofilament Proteins.
Title: Protein Kinase D Plays a Crucial Role in Maintaining Cardiac Homeostasis by Regulating Post-Translational Modifications of Myofilament Proteins.
Cardiac Protein Kinase D1 ablation alters the myocytes beta-adrenergic response.
Title: Cardiac Protein Kinase D1 ablation alters the myocytes β-adrenergic response.
IL-33 via PKCmu/PRKD1 Mediated alpha-Catenin Phosphorylation Regulates Endothelial Cell-Barrier Integrity and Ischemia-Induced Vascular Leakage.
Title: IL-33 via PKCμ/PRKD1 Mediated α-Catenin Phosphorylation Regulates Endothelial Cell-Barrier Integrity and Ischemia-Induced Vascular Leakage.
Protein kinase D1 (Prkd1) deletion in brown adipose tissue leads to altered myogenic gene expression after cold exposure, while thermogenesis remains intact.
Title: Protein kinase D1 (Prkd1) deletion in brown adipose tissue leads to altered myogenic gene expression after cold exposure, while thermogenesis remains intact.
Protein Kinase D1 Regulates Cardiac Hypertrophy, Potassium Channel Remodeling, and Arrhythmias in Heart Failure.
Title: Protein Kinase D1 Regulates Cardiac Hypertrophy, Potassium Channel Remodeling, and Arrhythmias in Heart Failure.
Protein kinase D1 variant associated with human epilepsy and peripheral nerve hypermyelination.
Title: Protein kinase D1 variant associated with human epilepsy and peripheral nerve hypermyelination.
The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease.
Title: The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease.
Adipose-specific knockout of Protein Kinase D1 suppresses de novo lipogenesis in mice via SREBP1c-dependent signaling.
Title: Adipose-specific knockout of Protein Kinase D1 suppresses de novo lipogenesis in mice via SREBP1c-dependent signaling.
Loss of protein kinase D activity demonstrates redundancy in cardiac glucose metabolism and preserves cardiac function in obesity.
Title: Loss of protein kinase D activity demonstrates redundancy in cardiac glucose metabolism and preserves cardiac function in obesity.
PKD1 mediates the PKC effects on KV11.1 and we found that PKD targets S284 in the N-terminus of the channel.
Title: PKD Phosphorylation as Novel Pathway of KV11.1 Regulation.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (9) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236839

NoName (e-PCR)
- UniSTS:548158

Prkcm (e-PCR), detects polymorphism
- UniSTS:144198

Prkcm (e-PCR), detects polymorphism
- UniSTS:480327

UniSTS:224841 (e-PCR)
- UniSTS:224841

BB362079 (e-PCR)
- UniSTS:208801

D12Mit64 (e-PCR), detects polymorphism
- UniSTS:126884

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to angiotensin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to endothelin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydroperoxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to norepinephrine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to phorbol 13-acetate 12-myristate	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptide hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sarcomere organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril	ISO Inferred from Sequence Orthology more info
involved_in response to norepinephrine	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase D1

Names: protein kinase C mu type; protein kinase C, mu; protein kinase D

NP_001369743.1

EC 2.7.11.13

NP_001369744.1

EC 2.7.11.13

NP_001369745.1

EC 2.7.11.13

NP_032884.2

EC 2.7.11.13

XP_006515649.1

EC 2.7.11.13

XP_006515653.1

EC 2.7.11.13

XP_006515654.1

EC 2.7.11.13

XP_036013143.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001382814.1 → NP_001369743.1 serine/threonine-protein kinase D1 isoform 2

Status: VALIDATED

Source sequence(s)

AC099603, AC154543, CT009740, CT010578

Conserved Domains (4) summary

cd01239
Location:414 → 541

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:577 → 836

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cd20839
Location:138 → 209

C1_PKD1_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins

cd20842
Location:235 → 328

C1_PKD1_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins
NM_001382815.1 → NP_001369744.1 serine/threonine-protein kinase D1 isoform 3

Status: VALIDATED

Source sequence(s)

AC099603, AC154543, CT010578
NM_001382816.1 → NP_001369745.1 serine/threonine-protein kinase D1 isoform 4

Status: VALIDATED

Source sequence(s)

CT009740

Conserved Domains (1) summary

cl21453
Location:6 → 37

PKc_like; Protein Kinases, catalytic domain
NM_008858.4 → NP_032884.2 serine/threonine-protein kinase D1 isoform 1

See identical proteins and their annotated locations for NP_032884.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC099603, AC154543, CT009740, CT010578

Consensus CDS

CCDS49059.1

UniProtKB/Swiss-Prot

E9QNA3, Q62101

Related

ENSMUSP00000002765.8, ENSMUST00000002765.9

Conserved Domains (5) summary

smart00220
Location:593 → 845

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00029
Location:277 → 326

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01239
Location:422 → 549

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:585 → 844

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

pfam00130
Location:145 → 194

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

NR_168537.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC099603, AC154543, CT009740, CT010578
NR_168538.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT009740
NR_168539.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT009740
NR_168540.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT009740
NR_168541.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT009740
NR_168542.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT009740
NR_168543.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT009740
NR_168544.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT009740
NR_168545.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT009740

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

50388009..50696075 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515586.3 → XP_006515649.1 serine/threonine-protein kinase D1 isoform X1

Conserved Domains (4) summary

cd00029
Location:277 → 326

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01239
Location:422 → 549

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:584 → 843

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

pfam00130
Location:145 → 194

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_036157250.1 → XP_036013143.1 serine/threonine-protein kinase D1 isoform X2

Conserved Domains (3) summary

cd01239
Location:259 → 386

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:422 → 681

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cl00040
Location:80 → 173

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_006515590.5 → XP_006515653.1 serine/threonine-protein kinase D1 isoform X2

See identical proteins and their annotated locations for XP_006515653.1

Conserved Domains (3) summary

cd01239
Location:259 → 386

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:422 → 681

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cl00040
Location:80 → 173

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_006515591.3 → XP_006515654.1 serine/threonine-protein kinase D1 isoform X3

Conserved Domains (4) summary

cd00029
Location:277 → 326

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01239
Location:422 → 549

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

pfam00130
Location:145 → 194

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:585 → 747

PKc_like; Protein Kinases, catalytic domain