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Prkacb protein kinase, cAMP dependent, catalytic, beta [ Mus musculus (house mouse) ]

Gene ID: 18749, updated on 21-Apr-2024

Summary

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Official Symbol
Prkacbprovided by MGI
Official Full Name
protein kinase, cAMP dependent, catalytic, betaprovided by MGI
Primary source
MGI:MGI:97594
See related
Ensembl:ENSMUSG00000005034 AllianceGenome:MGI:97594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CbPKA; Pkacb; PKA C-beta
Summary
Enables ATP binding activity; cAMP-dependent protein kinase activity; and magnesium ion binding activity. Involved in protein phosphorylation. Acts upstream of or within negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; neural tube closure; and regulation of protein processing. Located in ciliary base. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 53.9), CNS E18 (RPKM 48.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 H2; 3 72.28 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146435334..146518691, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146729579..146812946, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:146349571-146349754 Neighboring gene predicted gene, 36521 Neighboring gene high mobility group box 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09230 Neighboring gene STARR-positive B cell enhancer ABC_E4605 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:146444299-146444452 Neighboring gene capping protein (actin filament) muscle Z-line, alpha 1 pseudogene Neighboring gene ribosomal protein L11 pseudogene Neighboring gene tubulin tyrosine ligase-like family, member 7 Neighboring gene STARR-seq mESC enhancer starr_09232 Neighboring gene STARR-positive B cell enhancer ABC_E6145

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ablation of the Cβ2 subunit of PKA in immune cells leads to increased susceptibility to systemic inflammation in mice. Moen LV, et al. Eur J Immunol, 2017 Nov. PMID 28837222
  2. Identification and expression analysis of three novel splice variants of protein kinase A catalytic β subunit gene in the mouse using combinatorial in silico and molecular biology approaches. Banday AR, et al. FEBS J, 2012 Feb. PMID 22151102
  3. Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Madhusudan, et al. Nat Struct Biol, 2002 Apr. PMID 11896404
  4. Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase. Qi M, et al. Proc Natl Acad Sci U S A, 1996 Feb 20. PMID 8643673, Free PMC Article
  5. Systems-level identification of PKA-dependent signaling in epithelial cells. Isobe K, et al. Proc Natl Acad Sci U S A, 2017 Oct 17. PMID 28973931, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein kinase A signaling explains vasopressin-mediated regulation of membrane trafficking and gene transcription.
    Title: Systems-level identification of PKA-dependent signaling in epithelial cells.
  2. We suggest a role of the PRKACB gene splice variant Cbeta2 in regulating innate as well as adaptive immune sensitivity in vivo.
    Title: Ablation of the Cβ2 subunit of PKA in immune cells leads to increased susceptibility to systemic inflammation in mice.
  3. Gli2 and Gli3 are dephosphorylated and activated in cilia and that impaired Gli2 and Gli3 processing in Ta3 mutant is at least in part due to a decrease in Gli2 and Gli3 phosphorylation.
    Title: PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant.
  4. Data indicate that TRPV4 activity and TRPV4 trafficking are under discrete but synergistic control of PKC- and PKA-dependent pathways.
    Title: Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C.
  5. Studies identified three novel alternatively spliced transcript variants of the mouse protein kinase A catalytic beta subunit (Cbeta) gene designated Cbeta5, Cbeta6 and Cbeta7.
    Title: Identification and expression analysis of three novel splice variants of protein kinase A catalytic β subunit gene in the mouse using combinatorial in silico and molecular biology approaches.
  6. These data suggest that both developmental and tumor phenotypes caused by Prkar1a mutation result from excess PKA activity due to PKA-Ca.
    Title: Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.
  7. Murine lymphoid tissues express a protein that is a homologue of human and bovine Cbeta2
    Title: Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cbeta2.
  8. PKCbetaII is a target for colon cancer chemoprevention and the PKCbeta-selective inhibitor enzastaurin may represent an effective chemopreventive agent in patients at high risk for colon cancer.
    Title: Protein kinase Cbeta is an effective target for chemoprevention of colon cancer.
  9. crystal structure of the catalytic subunit in complex with ADP, aluminum fluoride, Mg2+ ions and a substrate peptide was determined at 2.0 A resolution
    Title: Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase.
  10. glucose and glucagon-like polypeptide-1 caused translocation of Calpha to the nucleus and of Cbeta to the plasma membrane and the nucleus, but did not affect the distribution of Cgamma in pancreatic beta-cells
    Title: Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cAMP-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
  
part_of cAMP-dependent protein kinase complex TAS
Traceable Author Statement
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase catalytic subunit beta
Names
Cbeta2 PKA
cAMP-dependent protein kinase C beta
NP_001157670.1
NP_001157671.1
NP_001157672.1
NP_001397387.1
NP_001397388.1
NP_001397389.1
NP_035230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164198.2 → NP_001157670.1  cAMP-dependent protein kinase catalytic subunit beta isoform 2

    See identical proteins and their annotated locations for NP_001157670.1

    Status: VALIDATED

    Source sequence(s)
    AC114618
    Consensus CDS
    CCDS51090.1
    UniProtKB/Swiss-Prot
    P68181
    Related
    ENSMUSP00000101743.2, ENSMUST00000106137.8
    Conserved Domains (1) summary
    cd14209
    Location:29 → 318
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  2. NM_001164199.2 → NP_001157671.1  cAMP-dependent protein kinase catalytic subunit beta isoform 3

    See identical proteins and their annotated locations for NP_001157671.1

    Status: VALIDATED

    Source sequence(s)
    AC114618
    Consensus CDS
    CCDS51091.1
    UniProtKB/Swiss-Prot
    P68181
    Related
    ENSMUSP00000101744.2, ENSMUST00000106138.8
    Conserved Domains (1) summary
    cd14209
    Location:30 → 319
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  3. NM_001164200.2 → NP_001157672.1  cAMP-dependent protein kinase catalytic subunit beta isoform 4

    See identical proteins and their annotated locations for NP_001157672.1

    Status: VALIDATED

    Source sequence(s)
    AC114618
    Consensus CDS
    CCDS51092.1
    UniProtKB/Swiss-Prot
    P68181
    Related
    ENSMUSP00000005164.8, ENSMUST00000005164.12
    Conserved Domains (2) summary
    PTZ00263
    Location:79 → 398
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd14209
    Location:89 → 378
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  4. NM_001410458.1 → NP_001397387.1  cAMP-dependent protein kinase catalytic subunit beta isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC114618

  5. NM_001410459.1 → NP_001397388.1  cAMP-dependent protein kinase catalytic subunit beta isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC114618, AC115889

  6. NM_001410460.1 → NP_001397389.1  cAMP-dependent protein kinase catalytic subunit beta isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC114618, AC115889

  7. NM_011100.5 → NP_035230.1  cAMP-dependent protein kinase catalytic subunit beta isoform 1

    See identical proteins and their annotated locations for NP_035230.1

    Status: VALIDATED

    Source sequence(s)
    AC114618, AC115889
    Consensus CDS
    CCDS17906.1
    UniProtKB/Swiss-Prot
    P68181, Q3TQH5, Q3UDD0, Q3UTH5
    Related
    ENSMUSP00000099573.4, ENSMUST00000102515.10
    Conserved Domains (1) summary
    cd14209
    Location:42 → 331
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    146435334..146518691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P68181.2 GenPept UniProtKB/Swiss-Prot:P68181

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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