Pgam1 phosphoglycerate mutase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pgam1provided by MGI
Official Full Name: phosphoglycerate mutase 1provided by MGI
Primary source: MGI:MGI:97552
See related: Ensembl:ENSMUSG00000011752 AllianceGenome:MGI:97552
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pgam-1; 2310050F24Rik
Summary: Enables phosphoglycerate mutase activity. Predicted to act upstream of or within glycolytic process. Located in myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to several human genes including PGAM1 (phosphoglycerate mutase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 262.8), kidney adult (RPKM 216.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 35.44 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (41900310..41907104)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (41911871..41918665)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis.
Title: Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis.
T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.
Title: T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.
PGAM1 deficiency ameliorates myocardial infarction remodeling by targeting TGF-beta via the suppression of inflammation, apoptosis and fibrosis.
Title: PGAM1 deficiency ameliorates myocardial infarction remodeling by targeting TGF-β via the suppression of inflammation, apoptosis and fibrosis.
these data indicate that PGAM1 knockdown is associated with busulfaninduced hypospermatogenesis and contributes to spermatogenic cell apoptosis by regulating the P53/Caspase 3/Caspase 6/Caspase 9 signaling pathway.
Title: PGAM1 knockdown is associated with busulfan‑induced hypospermatogenesis and spermatogenic cell apoptosis.
that PGAM1 plays a role in cell proliferation and neuroblast differentiation in the dentate gyrus via the phosphorylation of cAMP response element-binding protein in the hippocampus
Title: Phosphoglycerate Mutase 1 Promotes Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus by Facilitating the Phosphorylation of cAMP Response Element-Binding Protein.
PGAM1 correlates with spermatogenic dysfunction and affects the function of cell proliferation, apoptosis and migration.
Title: PGAM1 is Involved in Spermatogenic Dysfunction and Affects Cell Proliferation, Apoptosis, and Migration.
9630033F20Rik may play an important role in muscle wasting and that it has a distinguished characterization of gene network.[9630033F20Rik]
Title: Gene network of a phosphoglycerate mutase in muscle wasting in mice.
histidine-phosphorylated PGAM1 correlated with expression of PKM2 in tumor tissues; decreased pyruvate kinase activity in PKM2-expressing cells allows PEP-dependent histidine phosphorylation of PGAM1 and may provide an alternate glycolytic pathway
Title: Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pgam1 (e-PCR), detects polymorphism
- UniSTS:225868

Pgam1 (e-PCR), detects polymorphism
- UniSTS:225869

Pgam1 (e-PCR), detects polymorphism
- UniSTS:507134

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity	ISO Inferred from Sequence Orthology more info
enables bisphosphoglycerate mutase activity	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables intramolecular phosphotransferase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglycerate mutase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoglycerate mutase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in glyceraldehyde-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphoglycerate mutase 1

Names: BPG-dependent PGAM 1; PGAM-B; phosphoglycerate mutase isozyme B

NP_075907.2

EC 5.4.2.11

EC 5.4.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.