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Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent [ Mus musculus (house mouse) ]

Gene ID: 18574, updated on 5-Mar-2024

Summary

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Official Symbol
Pde1bprovided by MGI
Official Full Name
phosphodiesterase 1B, Ca2+-calmodulin dependentprovided by MGI
Primary source
MGI:MGI:97523
See related
Ensembl:ENSMUSG00000022489 AllianceGenome:MGI:97523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pde1b1
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within several processes, including response to amphetamine; serotonin metabolic process; and visual learning. Predicted to be located in cytoplasm. Predicted to be active in neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Orthologous to human PDE1B (phosphodiesterase 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 29.2), frontal lobe adult (RPKM 27.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Pde1b in Genome Data Viewer
Location:
15 F3; 15 58.99 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103411461..103438483)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103503034..103530056)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene MARCKS-like 1, pseudogene 3 Neighboring gene gametocyte specific factor 2 Neighboring gene NCK associated protein 1 like Neighboring gene STARR-seq mESC enhancer starr_39886 Neighboring gene STARR-seq mESC enhancer starr_39888 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 1A Neighboring gene glycosylation dependent cell adhesion molecule 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice. Hufgard JR, et al. Genes Brain Behav, 2017 Nov. PMID 28488329, Free PMC Article
  2. Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a. Hufgard JR, et al. Psychopharmacology (Berl), 2017 Jun. PMID 28337525
  3. Genomic structure and chromosome location of the murine PDE1B phosphodiesterase gene. Reed TM, et al. Mamm Genome, 1998 Jul. PMID 9657856
  4. Molecular cloning of DNA encoding a calmodulin-dependent phosphodiesterase enriched in striatum. Polli JW, et al. Proc Natl Acad Sci U S A, 1992 Nov 15. PMID 1332068, Free PMC Article
  5. Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme. Siuciak JA, et al. Neuropharmacology, 2007 Jul. PMID 17559891

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New Floxed Pde1b x CreCMV global knockout (KO) mice demonstrate depression-like behavioral resistance separate from stress-related effects.
    Title: Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice.
  2. Pde1b knock-out mice exhibited decreased tail suspension test and forced swim test immobilization; a model for depression.
    Title: Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a.
  3. These results prove that the kinetic properties of PDE isoforms play a major role in determining intracellular cAMP signals in response to physiological elevation of [Ca2+]i.
    Title: Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.
  4. The present studies demonstrate increased striatal dopamine turnover in PDE1B knockout mice associated with increased baseline motor activity and an exaggerated locomotor response to dopaminergic stimulants such as methamphetamine and amphetamine.
    Title: Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme.
  5. Data suggest a role for PDE1B in locomotor responses to psychostimulants through modulation of DARPP32-dependent pathways; however, this modulation does not necessarily impact other behaviors, such as anxiety or learning.
    Title: Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through DARPP32-dependent pathways: evidence from PDE1B-DARPP32 double-knockout mice.
  6. knock-out mice exhibit locomotor hyperactivity in response to dopamine agonists and display impaired spatial learning
    Title: Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect dopamine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to amphetamine IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to amphetamine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within serotonin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within visual learning IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Names
63 kDa Cam-PDE
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
cam-PDE 1B
phosphodiesterase 1B, Ca2+-calmodulin dependent, 63 kDa
phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa
NP_001272819.1
NP_001344909.1
NP_032826.1
XP_030104267.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285890.1 → NP_001272819.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and contains an alternate 5' terminal exon compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC131721, AK004772, CV784321, DN173601
    Consensus CDS
    CCDS88861.1
    UniProtKB/TrEMBL
    A0A2I3BPC1, Q6PDS5
    Related
    ENSMUSP00000153722.2, ENSMUST00000227955.2
    Conserved Domains (2) summary
    pfam00233
    Location:202 → 429
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:61 → 117
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  2. NM_001357980.1 → NP_001344909.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and contains an alternate 5' terminal exon compared to variant 1. The encoded protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC131721
    UniProtKB/TrEMBL
    Q6PDS5
    Conserved Domains (2) summary
    pfam00233
    Location:202 → 427
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:61 → 117
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  3. NM_008800.2 → NP_032826.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1

    See identical proteins and their annotated locations for NP_032826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC131721, BC058531, DN173601
    Consensus CDS
    CCDS27904.1
    UniProtKB/Swiss-Prot
    O35384, Q01065
    UniProtKB/TrEMBL
    Q6PDS5
    Related
    ENSMUSP00000023132.4, ENSMUST00000023132.5
    Conserved Domains (2) summary
    pfam00233
    Location:221 → 448
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:80 → 136
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    103411461..103438483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248407.1 → XP_030104267.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1

    UniProtKB/TrEMBL
    Q6PDS5, Q9DBS6
    Conserved Domains (2) summary
    pfam00233
    Location:181 → 408
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:40 → 96
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01065.2 GenPept UniProtKB/Swiss-Prot:Q01065

Gene LinkOut

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