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Pcbp2 poly(rC) binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 18521, updated on 21-Apr-2024

Summary

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Official Symbol
Pcbp2provided by MGI
Official Full Name
poly(rC) binding protein 2provided by MGI
Primary source
MGI:MGI:108202
See related
Ensembl:ENSMUSG00000056851 AllianceGenome:MGI:108202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrpx; alphaCP-2
Summary
Enables C-rich single-stranded DNA binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human PCBP2 (poly(rC) binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 95.3), limb E14.5 (RPKM 65.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F3; 15 57.61 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102378974..102408503)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102470450..102500068)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1179 Neighboring gene STARR-seq mESC enhancer starr_39843 Neighboring gene predicted gene, 24128 Neighboring gene proline rich 13 Neighboring gene STARR-positive B cell enhancer ABC_E8613 Neighboring gene STARR-seq mESC enhancer starr_39845 Neighboring gene predicted gene, 36331 Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene TARBP2, RISC loading complex RNA binding subunit Neighboring gene neuropeptide FF-amide peptide precursor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Poly C Binding Protein 2 dependent nuclear retention of the utrophin-A mRNA in C2C12 cells. Ghosh G, et al. RNA Biol, 2021 Nov 12. PMID 34904931, Free PMC Article
  2. Novel function of the poly(c)-binding protein α-CP2 as a transcriptional activator that binds to single-stranded DNA sequences. Kang DH, et al. Int J Mol Med, 2013 Nov. PMID 24026233, Free PMC Article
  3. Specific regulation of nucleocytoplasmic distribution of poly(C)-binding protein gene mRNA in mouse development. Hidai C, et al. Biochem Biophys Res Commun, 2003 Sep 19. PMID 12951055
  4. The poly(C)-binding protein Pcbp2 is essential for CD4(+) T cell activation and proliferation. Martinelli M, et al. iScience, 2023 Jan 20. PMID 36632062, Free PMC Article
  5. PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR. Yabe-Wada T, et al. FEBS Open Bio, 2020 Mar. PMID 31961070, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Poly C Binding Protein 2 dependent nuclear retention of the utrophin-A mRNA in C2C12 cells.
    Title: Poly C Binding Protein 2 dependent nuclear retention of the utrophin-A mRNA in C2C12 cells.
  2. RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis.
    Title: RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis.
  3. PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR.
    Title: PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR.
  4. Embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage. Compared to wild-type controls, transcript splicing analysis of the Pcbp2(-/-) embryonic liver reveals accentuated exclusion of an exon (exon 6) that encodes a highly conserved transcriptional control segment of the hematopoietic master regulator, Runx1.
    Title: Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript.
  5. These findings suggest that Hr mRNA expression is regulated at the post-transcriptional level via IRES-mediated translation control through interaction with PCPB2, but not in MUHH.
    Title: Poly(rC) binding protein 2 acts as a negative regulator of IRES-mediated translation of Hr mRNA.
  6. Study determined that PCBP2 specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators.
    Title: Poly(rC)-Binding Protein 2 Regulates Hippo Signaling To Control Growth in Breast Epithelial Cells.
  7. data suggest that PCBP2 regulates p73 expression via mRNA stability and p73-dependent biological function in ROS production and cellular senescence.
    Title: RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant Defense.
  8. PCBP2 overexpression rescues the Meis1 effects of Akt-mTOR pathway and hypertrophy of cardiomyocytes.
    Title: Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy.
  9. These data reveal that Pcbp1 and Pcbp2 are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.
    Title: The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.
  10. PCBP2 knockdown promoted angiotensin II-induced hypertrophy (increase in cell size, protein synthesis and activation of fetal genes) of cardiomyocytes, while PCBP2 overexpression obtained oppose effects.
    Title: The RNA-binding protein PCBP2 inhibits Ang II-induced hypertrophy of cardiomyocytes though promoting GPR56 mRNA degeneration.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107004

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-rich single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in IRES-dependent viral translational initiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cGAS/STING signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in viral RNA genome replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
poly(rC)-binding protein 2
Names
CBP
CTBP
alpha-CP2
heterogeneous nuclear ribonucleoprotein X
hnRNP X
putative heterogeneous nuclear ribonucleoprotein X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103165.2 → NP_001096635.1  poly(rC)-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001096635.1

    Status: VALIDATED

    Source sequence(s)
    AC137156
    Consensus CDS
    CCDS49741.1
    UniProtKB/Swiss-Prot
    Q61383, Q61990, Q62042
    Related
    ENSMUSP00000076294.6, ENSMUST00000077037.13
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:281 → 356
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  2. NM_001103166.2 → NP_001096636.1  poly(rC)-binding protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001096636.1

    Status: VALIDATED

    Source sequence(s)
    AC137156
    Consensus CDS
    CCDS49742.1
    UniProtKB/Swiss-Prot
    Q61990
    UniProtKB/TrEMBL
    Q3TT81
    Related
    ENSMUSP00000155430.2, ENSMUST00000229618.2
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:250 → 325
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  3. NM_001174073.2 → NP_001167544.1  poly(rC)-binding protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001167544.1

    Status: VALIDATED

    Source sequence(s)
    AC137156
    Consensus CDS
    CCDS88856.1
    UniProtKB/TrEMBL
    Q3TT81
    Related
    ENSMUSP00000104466.5, ENSMUST00000108838.5
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:241 → 316
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  4. NM_001374771.1 → NP_001361700.1  poly(rC)-binding protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC137156
    Consensus CDS
    CCDS88857.1
    UniProtKB/TrEMBL
    B2M1R7
    Related
    ENSMUSP00000155789.2, ENSMUST00000230114.2
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:280 → 355
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  5. NM_001411538.1 → NP_001398467.1  poly(rC)-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC137156

  6. NM_001411539.1 → NP_001398468.1  poly(rC)-binding protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC137156
    UniProtKB/Swiss-Prot
    Q61383, Q61990, Q62042

  7. NM_001411540.1 → NP_001398469.1  poly(rC)-binding protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC137156

  8. NM_001411541.1 → NP_001398470.1  poly(rC)-binding protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC137156

  9. NM_001411542.1 → NP_001398471.1  poly(rC)-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC137156

  10. NM_001411543.1 → NP_001398472.1  poly(rC)-binding protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC137156

  11. NM_001411544.1 → NP_001398473.1  poly(rC)-binding protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC137156

  12. NM_001411545.1 → NP_001398474.1  poly(rC)-binding protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC137156

  13. NM_001411546.1 → NP_001398475.1  poly(rC)-binding protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC137156

  14. NM_001411547.1 → NP_001398476.1  poly(rC)-binding protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC137156

  15. NM_001411548.1 → NP_001398477.1  poly(rC)-binding protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC137156

  16. NM_001411549.1 → NP_001398478.1  poly(rC)-binding protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC137156
    UniProtKB/TrEMBL
    B2M1R7

  17. NM_001411550.1 → NP_001398479.1  poly(rC)-binding protein 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC137156

  18. NM_001411551.1 → NP_001398480.1  poly(rC)-binding protein 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC137156

  19. NM_001411552.1 → NP_001398481.1  poly(rC)-binding protein 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC137156

  20. NM_001411553.1 → NP_001398482.1  poly(rC)-binding protein 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC137156

  21. NM_001411554.1 → NP_001398483.1  poly(rC)-binding protein 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC137156

  22. NM_001411555.1 → NP_001398484.1  poly(rC)-binding protein 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC137156

  23. NM_001411556.1 → NP_001398485.1  poly(rC)-binding protein 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC137156

  24. NM_001411557.1 → NP_001398486.1  poly(rC)-binding protein 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC137156

  25. NM_001411558.1 → NP_001398487.1  poly(rC)-binding protein 2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC137156

  26. NM_001411559.1 → NP_001398488.1  poly(rC)-binding protein 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC137156

  27. NM_011042.3 → NP_035172.2  poly(rC)-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_035172.2

    Status: VALIDATED

    Source sequence(s)
    AC137156
    Consensus CDS
    CCDS27884.1
    UniProtKB/Swiss-Prot
    Q61990
    UniProtKB/TrEMBL
    Q3TT81
    Related
    ENSMUSP00000155038.2, ENSMUST00000229854.2
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:268 → 343
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102378974..102408503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248387.1 → XP_030104247.1  poly(rC)-binding protein 2 isoform X7

    Conserved Domains (2) summary
    cd02396
    Location:99 → 163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:274 → 336
    KH_1; KH domain

  2. XM_006520582.4 → XP_006520645.1  poly(rC)-binding protein 2 isoform X16

    See identical proteins and their annotated locations for XP_006520645.1

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:285 → 360
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  3. XM_017316497.2 → XP_017171986.1  poly(rC)-binding protein 2 isoform X17

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:284 → 359
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  4. XM_006520583.4 → XP_006520646.1  poly(rC)-binding protein 2 isoform X20

    See identical proteins and their annotated locations for XP_006520646.1

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:272 → 347
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  5. XM_017316499.2 → XP_017171988.1  poly(rC)-binding protein 2 isoform X21

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:271 → 346
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  6. XM_006520584.4 → XP_006520647.1  poly(rC)-binding protein 2 isoform X24

    See identical proteins and their annotated locations for XP_006520647.1

    UniProtKB/TrEMBL
    A0A2R8VHP9
    Related
    ENSMUSP00000155292.2, ENSMUST00000229802.2
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:254 → 329
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  7. XM_030248401.1 → XP_030104261.1  poly(rC)-binding protein 2 isoform X25

    Related
    ENSMUSP00000155654.2, ENSMUST00000229184.2
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:253 → 328
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  8. XM_006520585.4 → XP_006520648.1  poly(rC)-binding protein 2 isoform X28

    See identical proteins and their annotated locations for XP_006520648.1

    UniProtKB/TrEMBL
    Q3TT81
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:241 → 316
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  9. XM_017316501.2 → XP_017171990.1  poly(rC)-binding protein 2 isoform X29

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:240 → 315
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  10. XM_011245495.3 → XP_011243797.1  poly(rC)-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011243797.1

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:285 → 360
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  11. XM_011245497.3 → XP_011243799.1  poly(rC)-binding protein 2 isoform X2

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:284 → 359
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  12. XM_011245501.3 → XP_011243803.1  poly(rC)-binding protein 2 isoform X5

    See identical proteins and their annotated locations for XP_011243803.1

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:272 → 347
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  13. XM_011245502.3 → XP_011243804.1  poly(rC)-binding protein 2 isoform X6

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:271 → 346
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  14. XM_011245503.3 → XP_011243805.1  poly(rC)-binding protein 2 isoform X9

    See identical proteins and their annotated locations for XP_011243805.1

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:254 → 329
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  15. XM_030248391.1 → XP_030104251.1  poly(rC)-binding protein 2 isoform X10

    Conserved Domains (2) summary
    cd02396
    Location:99 → 163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:259 → 321
    KH_1; KH domain

  16. XM_030248392.1 → XP_030104252.1  poly(rC)-binding protein 2 isoform X13

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:241 → 316
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  17. XM_030248389.1 → XP_030104249.1  poly(rC)-binding protein 2 isoform X8

    Conserved Domains (2) summary
    cd02396
    Location:99 → 163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:273 → 335
    KH_1; KH domain

  18. XM_030248394.1 → XP_030104254.1  poly(rC)-binding protein 2 isoform X15

    Conserved Domains (2) summary
    cd02396
    Location:99 → 163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:242 → 304
    KH_1; KH domain

  19. XM_011245496.2 → XP_011243798.1  poly(rC)-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011243798.1

    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:285 → 360
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  20. XM_030248390.1 → XP_030104250.1  poly(rC)-binding protein 2 isoform X8

    Conserved Domains (2) summary
    cd02396
    Location:99 → 163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:273 → 335
    KH_1; KH domain

  21. XM_030248393.1 → XP_030104253.1  poly(rC)-binding protein 2 isoform X14

    Conserved Domains (2) summary
    cd02396
    Location:99 → 163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:243 → 305
    KH_1; KH domain

  22. XM_011245509.2 → XP_011243811.1  poly(rC)-binding protein 2 isoform X15

    Conserved Domains (2) summary
    cd02396
    Location:99 → 163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:242 → 304
    KH_1; KH domain

  23. XM_030248396.1 → XP_030104256.1  poly(rC)-binding protein 2 isoform X18

    UniProtKB/Swiss-Prot
    Q61383, Q61990, Q62042
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:281 → 356
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61990.1 GenPept UniProtKB/Swiss-Prot:Q61990

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